Research works

Nanopore Sequencing for Epigenetic Decoding: Applications, Analytical Constraints, and Translational Prospects

Epigenetic regulation involves multiple molecular layers, including DNA and RNA modifications, histone post-translational modifications (PTMs), and chromatin accessibility. These processes contribute to cell identity, development, and disease, but their measurement remains techni...

Collectivism meets self-optimization: Thai cultural values and the paradox of self-development

The global self-development industry rests on a culturally particular model of the person. Its characteristic prescriptions (set your own goals, put yourself first, promote your strengths, defend your boundaries) presuppose an independent self for whom other people are context ra...

Functional orthopedic outcomes in children with myelomeningocele across the Indian Ocean region: a cohort study

In patients with a myelomeningocele, ambulation and autonomy play a significant role in determining their quality of life and participation. The objective of this study was to describe functional orthopedic outcomes of children with myelomeningocele cared for or referred to a uni...

Golden Ratio Emerges as Fixed Point in Prefix-Free Code Trees — E8 Intelligence Research

FINDING: Prefix-free codes form binary trees whose branching structure connects to irrational-ratio self-similarity, with golden ratio Φ appearing as a stable fixed point in self-referential computation. | MATH: Prefix-free (Kraft) inequality: Σ 2^(−l_i) ≤ 1, where l_i are codewo...

NUCLEAR FISSION OF TRANSURANICS IN THE SOLAR CORE AND ACTINIDE CHAIN REACTIONS AS THE ENERGY SOURCE AND COLLAPSE TRIGGER IN WHITE DWARFS AND NEUTRON STARS

ABSTRACT (ARTICLE OVERVIEW) This research paper, developed by an independent and self-governing scientific research group under the leadership of Stanislav Kozlov, establishes advanced methodologies for investigating compact macrobodies and the Sun, representing a radical breakth...

Knowledge, Attitude, and Perception toward Black-Box and Scheduled Drug Warnings Among Undergraduate Medical Students: A Cross-Sectional Study in a Tertiary Medical Institution in Andhra Pradesh, India

AbstratctIntroduction: Black Box Warnings (BBW) issued by the U.S. Food and Drug Administration (FDA) identify serious or life-threatening risks associated with certain medicines. In India, scheduled-drug warnings issued under the regulatory framework of the Central Drugs Standar...

Psychological Stress and the Diurnal Patterns of Sodium Excretion and Blood Pressure: Results From the SABRE Study

BACKGROUND: Psychological stress is associated with reduced blood pressure (BP) dipping, but the underlying mechanisms are unclear. This study examined the associations among stress-induced sodium excretion, diurnal sodium excretion, and BP dipping. METHODS: Apparently healthy ad...

Two new species of Callidosomatinae Southcott, 1961 (Trombidiformes: Erythraeidae) from the Carajás region, eastern Brazilian Amazon

The diversity of Callidosomatinae in the Neotropical region remains poorly known, particularly in megadiverse ecosystems such as the Amazon. In this study, two new species of Callidosomatinae, belonging to the genera Callidosoma and Iguatonia, are described based on specimens col...

Pressure-Driven Topological Reconfiguration toward Fast-Charging Hard Carbon with Plateau-Capacity Retention

Abstract Conventional carbonization of semi-coke induces excessive ordering of aromatic skeletons, producing dense graphitic structures that hinder Na+ intercalation and suppress low-potential plateau capacity. Here, we develop a rapid thermomechanical coupling sintering strategy...

Empirical Evaluation of the Repertory Rubric “Anger, Consoled, when” Using Likelihood Ratio-based Prognostic Factor Analysis in Individualized Homeopathic Practice

Abstract The rubric “Anger, consoled, when” is described in several homeopathic repertories and materia medica sources, but its prognostic relevance has not been quantitatively examined. This study applied likelihood ratio (LR)-based prognostic factor research (PFR) to evaluate i...

Life-threatening diffuse alveolar hemorrhage associated with Rhinovirus infection and the potential role of corticosteroids in immunocompetent patients

Rationale: Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal condition characterized by bleeding into alveolar spaces, most often associated with autoimmune disease or severe infection. Rhinovirus is a common cause of upper respiratory tract infection but is rarel...

Dual-energy computed tomography pulmonary angiography for pulmonary embolism: a three-tier evidence framework to guide individualized low-iodine scanning

Dual-energy computed tomography (DECT) pulmonary angiography (CTPA) is widely studied for pulmonary embolism (PE) evaluation, but heterogeneity in protocols, platforms, and study designs complicates its clinical positioning. This narrative review, with structured search elements...

Development and Genomic Validation of a Population-Specific SNP Panel for Parentage Verification in Chinese Holstein Cattle

Accurate pedigree information is essential for genetic evaluation and genomic selection in dairy cattle. However, the performance of SNP-based parentage verification depends on marker informativeness, genomic distribution, and compatibility with the target population. In this stu...

Menstrual cycle-related neurotrophic and inflammatory variation differs between adult females with and without Major Depressive Disorder

Abstract Background The pathophysiology of Major Depressive Disorder (MDD), which disproportionately affects females, has been linked to neuroimmune mechanisms. However, many canonical biomarkers of MDD may be influenced by physiological changes across the menstrual cycle. Despit...

A Proper Subclass of the Separable Permutations Whose Generating Function Lies Outside Q(z, √(1−4z), √(1−6z+5z²))

Question 5 of R. Brignall's abstract (joint work with M. Bóna, C. Defant, M. Opler and V. Vatter) in Oberwolfach Report 6/2024, p. 292, asks whether every proper subclass of the separable permutations Av(2413, 3142) has a generating function in K = Q(z, √(1−4z), √(1−6z+5z²)). The...

Modular Arithmetic's Role in Cryptography and Hyperbolic Lattice Structures — E8 Intelligence Research

FINDING: Modular arithmetic is foundational to cryptography and connects to deep lattice structures in hyperbolic geometry, but the search results are mostly pedagogical videos with one substantive arxiv paper on arithmetic lattices. | MATH: Modular arithmetic: a ≡ b (mod m) ⇔ m...

Special Issue “Natural Products in Drug Discovery and Development: 2nd Edition”

The Special Issue “Natural Products in Drug Discovery and Development” returns for a second edition at a time when nature-derived molecules continue to demonstrate their enduring value to medicine [...]

Changes in retinal light sensitivity and morphometry during surgical treatment of primary glaucoma with physiotherapeutic stimulation

Surgery for advanced stages of primary open-angle glaucoma (POAG) aims to normalize intraocular pressure (IOP). A course of physiotherapy during subsequent stages of surgical treatment may have an additional beneficial effect. OBJECTIVE: The study evaluated the effect of physioth...

ZnO-Enhanced Cu/ZrO2 for Photothermal Catalytic CO2 Hydrogenation to Methanol

Abstract The photothermal conversion of CO2 to methanol represents a sustainable pathway for energy storage and carbon neutrality. However, most highly active photothermal catalysts have been evaluated under Xenon-lamp irradiation, in which the photothermal effect arises predomin...

Research Progress on Offline Defect-Detection Technologies for Selective Laser-Melting Parts

Selective laser melting (SLM) is recognized as one of the most promising metal additive manufacturing technologies for industrial deployment and has been applied to fabricate precision components for high-end equipment in sectors including aerospace and biomedicine. Nevertheless,...