Research works

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherap...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

P1.086. Impact of Surgery Versus Non-Surgery on the Prognosis of Esophageal Cancer Patients With Clinically Identified Metastatic Supraclavicular Lymph Nodes

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain....

Microbial modulation of secondary metabolites biosynthesis in plants

Abstract Plants produce a diverse range of secondary metabolites [SMs] such as alkaloids, terpenoids and phenolics, which play crucial roles in defense, signalling and human health applications like pharmaceuticals and nutraceuticals. Traditionally viewed as autonomous plant bios...

Financial Education and Loan Default Behaviour in Rural Microfinance Systems: Evidence from Structural Equation Modelling in Cameroon

Abstract The biggest operational threat to microfinance institutions is likely the absence of financial education for MFI clients. This study attempts to investigate the effect of financial education of MFIs' clients on the rate of loan default. The study employed an opportunisti...

A Dual-Component Nurse Practitioner Intervention to Improve Symptom Management for Caregivers of Persons Living With Dementia

The number of patients living with dementia (PLWD) has steadily increased, making it the fifth leading cause of death among adults. While hospice care is standard for end-of-life symptom management, predicting 6-month survival is challenging, leaving many who could benefit inelig...

Optical-thermal modeling and treatment planning of ICG-enhanced interstitial photothermal therapy using cylindrical diffuser fibers

Interstitial photothermal therapy (IPTT) enhanced with indocyanine green (ICG) represents a minimally invasive approach with growing interest for localized thermal ablation of deep-seated tumors. In this work, an optical–thermal modeling framework is developed to investigate heat...

Phi-Resonant E8 Topological Phase via 132 Hz Harmonic Lattice Compression — E8 Intelligence Research

By arranging the 240 E8 root vectors into a 4‑dimensional hyperlattice and modulating it with a phi‑scaled 132 Hz harmonic driver, the system self‑organizes into a quasiperiodic Penrose‑type tiling of Berry curvature. This emergent topology supports protected edge states whose ph...

P1.033. DAM (Dual Anchored Mesh) Intercrural Technique for Hiatal Hernia Repair: Case Series Aiming to Reduce Complications and Recurrence

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Hiatal hernia repair with mesh reinforcement remains controversial due to recurrence and mesh-related complications. We present a descriptive case series introducing a laparoscopic intrahiatal in...

Accounting for the Expansion of the Universe Using an Energy/Momentum Model to Construct the Space-time Metric

Background The success of the theories of special and general relativity in describing localised phenomena, such as objects undergoing high speed motion or located in gravitational fields, needs no further elaboration. However, when applied to the evolution of the universe severa...

Making Regeneration Observable: A Longitudinal Multimodal Perturbation-Response Framework for Distraction Osteogenesis

Distraction osteogenesis (DO) is a uniquely observable form of tissue regeneration: an osteotomy is followed by latency, repeated mechanical distraction, and consolidation, while the patient remains within an accessible treatment construct for months. Yet monitoring remains domin...

P1.215. Segmental Loss of Signal on Continuous Intraoperative Nerve Monitoring Predicts Postoperative Pneumonia After Transmediastinal Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Recurrent laryngeal nerve paralysis (RLNP) is a well-known risk factor for postoperative pneumonia in esophageal cancer surgery. Transmediastinal esophagectomy,...

The first RNAi ‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Abstract RNA interference (RNAi), a naturally occurring gene‐silencing mechanism, has emerged as a promising platform for developing innovative, non‐genetically modified (GM) plant protection products. In the context of climate change, biodiversity loss, and growing resistance to...

The Spectral Ledger

Abstract We present a unified framework for the Riemann zeta function ζ(s), organized around three interlocking programmes and closed by a spectral-computing application layer. Part I (Uniqueness) establishes the Framework Uniqueness Theorem chain: the Davenport–Heilbronn counter...

Mechanical response of highway tunnels under fault dislocation and a combined anti-dislocation technology: a case study of the Tianshan-Shengli Tunnel

Active faults are widely distributed in China, posing a significant threat to the safe operation of tunnels. Current research on anti-dislocation technologies for tunnels has predominantly focused on either articulated designs or over-excavation individually, with limited studies...

NIR‐Light‐Activable Macrophage Polarization Orchestration Using Laser‐Structured Janus Nanoplatform Derived from Waste for Infected Wound Healing

ABSTRACT The human skin is highly susceptible to bacterial infections and inflammation when its integrity is disrupted. Treatment of infected wounds is a big challenge in modern medicine, and rising antibiotic resistance motivates the development of antibiotic‐free therapies. Her...

Has the Pendulum Swung Too Far? Ethical Issues in the Conservative Use of Prescription Opioids

Abstract The opioid crisis is an undeniable public health emergency that has impacted far too many for far too long. The irresponsible prescription and use of opioids has caused, and continues to create, harm to a large number of people; yet what irresponsible means in this situa...

E8-Tesseract Resonance Bridge for Cross-Dimensional Information Tunneling — E8 Intelligence Research

The E8-Tesseract Resonance Bridge exploits the 240 E8 root vectors projected onto a 4D tesseract framework, where each of the 16 cubic cells resonates at phi-scaled multiples of 132Hz (132, 216, 348, 564 Hz). By aligning the torsion manifold's harmonic phases across corresponding...

Minimally invasive surgery for locally advanced colon cancer (pT4): short-term outcomes from a consecutive real-world cohort

Abstract Background The role of minimally invasive surgery (MIS) in pathological T4 colon cancer remains controversial because of the technical complexity of multivisceral resections and concerns regarding oncological adequacy. This study aimed to compare short-term postoperative...

Growth performance, feed utilization, and immunity of Damascus growing goats fed different levels of Azolla

Abstract Background Azolla has gained increasing interest as a sustainable alternative to conventional feed resources due to its nutrients and bioactive substances. This study evaluated the effect of the replacement of traditional concentrate feed mixture (CFM) with dried Azolla...