Research works

Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations

Abstract Epileptogenesis is increasingly recognized as a multifactorial process driven by persistent neuroinflammation, oxidative stress, and dysregulated intracellular signaling, highlighting the need for therapeutic strategies that extend beyond symptomatic seizure control. The...

Clinical impact of routine second‑opinion reading of [¹⁸F]FDG‑PET/CT in newly diagnosed invasive bladder cancer: A multicentre study in a centralised referral network

Abstract Purpose [¹⁸F]FDG‑PET/CT is increasingly used to stage invasive bladder cancer (IBC), resulting in growing demand at tertiary centres for time‑intensive second‑opinion reading of externally acquired scans. However, the incremental clinical value of routine reinterpretatio...

KHALL KII™: The Universal Voice of Intelligence and Value

The convergence of artificial intelligence, cryptocurrency, and blockchain has created a communication crisis: professionals must navigate fragmented applications, wallets, agents, and protocols to accomplish what should be a single action. KHALL KII™ introduces a voice-first com...

Multiple shoot induction from embryonic axes of mature seeds supports a novel regeneration platform for biolistic DNA delivery in Theobroma cacao L.

Abstract Theobroma cacao L. genetic transformation still relies predominantly on somatic embryogenesis-based systems, which are often genotype-dependent, labor-intensive, and associated with prolonged culture periods. In this study, we developed an alternative regeneration platfo...

Accuracy and Clinical Applicability of Automated 3D CBCT-based Cephalometric Analysis in Children and Adolescents

This study aimed to evaluate the accuracy and clinical applicability of an automated landmark identification (ALI) system for three-dimensional cone-beam computed tomography (CBCT)-based cephalometric analysis in pediatric and adolescent patients. The influence of dentition stage...

Holonomic D‑Modules on Complex Curves and Mirror Pullback : A Structure‑Preserving Comparison via Automorphisms

This paper introduces the mirror pullback of holonomic D‑modules on complex curves, a structure‑preserving comparison defined via automorphisms. It maintains one‑dimensional thickness, transforms monodromy naturally, and provides a new framework consistent with the Riemann–Hilber...

Targeted Modulation of Zn Deposition Behavior toward High-Performance Stable Zn Anodes

Abstract Dendrite growth and parasitic side reactions at the Zn metal anode remain critical obstacles to the commercialization of aqueous zinc-ion batteries (AZIBs). Zn anode design regulates Zn deposition behavior from its thermodynamic and kinetic roots and is therefore recogni...

Biological Morphogenesis Governed by a Complex Generative Index

Biological morphogenesis is described using a complex generative index whose real and imaginary parts govern growth and chirality. Its induced monodromy field organizes spirals, layers, and branches, yielding a unified dynamical and singularity-based framework for biological form...

Anisotropic AlSi10Mg plate lattice structures via LPBF single-laser-track exposure: microstructural integrity, mechanical behavior and lightweight efficiency

Abstract Thin-walled plate lattice structures fabricated from AlSi10Mg via laser powder bed fusion (LPBF) promise exceptional stiffness-to-weight ratios for lightweight applications. However, wall thicknesses below $$\sim {500}{\upmu }{\textrm{m}}$$ commonly introduce geometric v...

Giant intraosseous lipoma of the ilium with acetabular involvement and pathologic fracture: a case report

Abstract Background Intraosseous lipoma is an uncommon benign lipogenic bone tumor, often underdiagnosed because many lesions are asymptomatic. Case presentation A 50-year-old man presented with left hip pain and limited mobility after a fall. Radiographs showed a large expansile...

The role of toll-like receptors in tributyltin-, dibutyltin-, and pentachlorophenol-induced stimulation of tumor necrosis factor-alpha (TNFα) production in human immune cells

Abstract Tributyltin (TBT), Dibutyltin (DBT), and Pentachlorophenol (PCP) are persistent environmental contaminants that increase immune-cell production of pro-inflammatory cytokines and thus have the capacity to cause chronic inflammation and its associated pathologies such as c...

Developing and evaluating automated deep learning and human-in-the-loop vision–language systems for microplastic characterization

Abstract Microplastic (MP) pollution poses escalating environmental risks, demanding efficient and reproducible tools for morphological characterization of plastic particles. Traditional manual microscopy is labour-intensive, operator-dependent, and poorly suited to large-scale m...

CaMK4 drives pathogenic Th17 cell response via the STAT3/RORγt axis in psoriasis

Abstract Psoriasis is a chronic inflammatory skin disease driven by dysregulated immune responses, particularly those mediated by pathogenic Th17 cell response; however, the key intracellular signaling molecules that specifically regulate Th17 cell pathogenicity in the skin remai...

One Patient, Two Problems: Applying Short Bowel Syndrome Management Principles in Inflammatory Bowel Disease patients

Abstract Purpose of Review Surgery for inflammatory bowel disease (IBD) often results in alterations in gut function beyond the anatomical changes. While some patients develop short bowel syndrome (SBS), a significant proportion of IBD patients benefit from pharmacologic and diet...

Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture

Abstract Background The sarcopenia index (SI), defined as the ratio of serum creatinine to cystatin C, is a proposed biomarker of muscle mass and sarcopenia, yet its genomic basis and genetic architecture remain largely unexplored. Methods We performed combined-sex and sex-strati...

Seasonal migration and habitat shifts of the cyprinid fish Schizothorax eurycephalus in a Central Asian mountain river

Abstract Freshwater biodiversity in Central Asia faces increasing pressure from anthropogenic impacts. A group of fish species of ecological and economical importance in the area are snow trout, cyprinids of the genus Schizothorax . However, fundamental knowledge to aid species c...

The physical work environment in management research: a bibliometric analysis of knowledge structures, collaboration networks, and workplace transformations

Abstract This article offers a comprehensive bibliometric analysis of research on physical work environments and maps its intellectual structure, thematic evolution, and collaborative dynamics over the past four decades from a business and management perspective. It reveals how p...

Impact of an Asynchronous E-learning Intervention on Cancer Knowledge and Clinical Practice for Pre-registration Nursing and Allied Health Professions Students and Cancer Support Workers

Abstract Pre-registration nursing and allied health professions students and cancer support workers can feel unprepared to care for people affected by cancer and at the end of life. To address this need, nine e-learning modules, collectively called ‘Foundations of Cancer Care’, h...

An Indicator-Based Framework for Measuring the Level of On-Site Industrialized Construction in Concrete Residential Buildings

Abstract Prefabricated construction (PC) and on-site industrialized construction (OIC) have demonstrated great potential in enhancing sustainability in industrialized construction (IC) of concrete residential buildings. However, existing IC evaluation frameworks worldwide have pa...

The organelle interactome in osteoarthritis: from subcellular dysfunction to joint degeneration

Abstract Osteoarthritis (OA) has long been described as a “wear and tear” degenerative joint disorder, yet this definition fails to capture the complexity of the disease. Emerging evidence suggests that OA is more accurately characterized as a whole-joint disorder involving coord...