Research works

In vitro activity of aztreonam-avibactam against carbapenem-resistant Pseudomonas aeruginosa from Southern Brazil

Abstract Carbapenem-resistant Pseudomonas aeruginosa (CR-PA) has limited therapeutic options, particularly when metallo-β-lactamases are present. We evaluated aztreonam-avibactam (AZA) against 48 clinical P. aeruginosa isolates, including 44 CR-PA with 18 difficult-to-treat resis...

Investigation of North Sea high-frequency sea-level extremes using long-term sea-level measurements

Abstract Extreme sea-level events occur across a range of temporal and spatial scales, including high-frequency oscillations (periods T < 2 h). However, most research uses hourly or daily data and neglects higher-frequency processes such as seiches and meteotsunamis. This study i...

The Omni–Carlo Unified Field: Complete Core Paper and Extended Carlo Volume

This document presents the full architecture of the Omni–Carlo Unified Field, the terminal fusion of all twelve Carlo engines into a single hyperdimensional cognitive manifold. It contains both the original core paper and the fully expanded Carlo Volume, detailing the origins of...

Stress responses and dynamic equilibrium: key determinants of ageing in the Caenorhabditis elegans clk-1 mutant

Abstract Systems biology offers valuable insights into ageing by integrating experimental data with mathematical models and bioinformatics tools. Long-lived mutants of Caenorhabditis elegans, particularly clk-1, have provided extensive data on the ageing mechanisms. The clk-1 gen...

The Omni–Carlo Unified Field: Complete Core Paper and Extended Carlo Volume

This document presents the full architecture of the Omni–Carlo Unified Field, the terminal fusion of all twelve Carlo engines into a single hyperdimensional cognitive manifold. It contains both the original core paper and the fully expanded Carlo Volume, detailing the origins of...

The protection and security of Christian holy sites: an environmental criminology approach with an emphasis on place-based factors

Abstract Christian holy sites combine high symbolic value with routine public accessibility and often contain valuable heritage objects. This combination of permeability, visibility constraints, and limited guardianship can generate vulnerability to routine harms such as vandalis...

Beyond Accuracy: Measuring Reasoning Consistency Under Quantization in Small Language Models

Quantization enables large language models to run on consumer hardware, but evaluation has focused almost exclusively on mean accuracy, leaving output consistency largely unexamined. We address this gap by evaluating Phi-3.5-mini-instruct at three precision levels, FP16, 4-bit, a...

A Minimal Machine Thesis of the Functional Present

Conceptual hypothesis; not empirical evidence. Not implemented; no test was run. This bilingual technical note distinguishes the constitutive present state of a machine — the state that currently obtains and carries execution — from represented past and future states, which are p...

Herbarium specimens in the age of artificial intelligence: from herbarium image identification to Integrative Taxonomic AI

Abstract Herbarium specimens are physical, verifiable records that form the basis of taxonomic knowledge and biodiversity research. Their large-scale digitization has produced extensive collections of high-resolution images and associated specimen metadata, creating conditions in...

Metagenomic insights into the metabolic versatility in iron-rich mats of the lucky strike hydrothermal field

Abstract Background Iron-rich microbial mats from the Lucky Strike Hydrothermal Field represent critical interfaces between geochemical energy sources and carbon cycling. While the taxonomic diversity of these mats has been explored in previous studies, their functional diversity...

Quantitative assessment of temporal bone anatomy on preoperative CT in acquired cholesteatoma: validation of current methods and correlation to outcomes after surgery

Abstract Objective 1. To identify methods of quantitative assessment of temporal bone anatomy on preoperative imaging in patients with primary acquired cholesteatoma. 2. To analyze the reproducibility of the identified methods. 3. To investigate whether quantitative assessment of...

Molecular predictors of recurrence in vestibular schwannomas: a transcriptomic and RT-qPCR analysis

Abstract Purpose Vestibular schwannomas (VS) are benign tumors with variable clinical behavior. Recurrence after surgery is uncommon yet sometimes aggressive. Reliable molecular predictors of recurrence are lacking, and the correlation between genotype and phenotype is weak. This...

Sharp Initial Thresholds for Abelian-Bordered Binary Infinite Words

Let mu_ab(x) denote the maximum length of an Abelian-unbordered factor of a binary infinite word x. We determine the first sharp threshold layers: mu_ab(x) at most 13 forces ordinary ultimate periodicity with sharp eventual-period bound 13; the least finite value attained by a no...

Approaching an unknown communication system by latent space exploration and causal inference

Abstract We propose a methodology for discovering meaningful properties in data without ground truth by combining manipulation of the latent variables of generative models to extreme values with causal inference in an approach we call causal disentanglement with extreme values (C...

William Frank Vinen

Abstract William Frank Vinen, known to everyone as Joe, was one of the outstanding physicists of his generation. In 1953 he joined the Royal Society Mond Laboratory as a research student, where he first investigated the propagation of temperature waves (second sound) in superflui...

Explainable artificial intelligence reveals key surgical parameters in robot-assisted and open radical prostatectomy

Abstract Preoperative risk stratification for radical prostatectomy is crucial, yet predicting the wide range of postoperative outcomes remains a significant challenge. While machine learning (ML) shows promise, “black box” models limit clinical translatability. This study aimed...

Whole genome sequencing of the finless porpoise

The whole genome sequencing of the finless porpoise Neophocaena asiaeorientalis. This project generates a high-quality (T2T) genome based on PacBio HiFi reads and Nanopore extra long reads. Additionally, a large-scale whole genome resequencing of the population will be conducted...

Quantum steering based on partial state information

Abstract Exploiting partial knowledge of a qubit in terms of its basis-dependent measure of imaginarity, we formulate a steering criterion for bipartite qubit systems, which requires two dichotomic measurements at the untrusted side and two mutually unbiased bases at the trusted...

Fundamentals of modelling and simulation in physiology: a step-by-step cardiopulmonary model tutorial

Abstract Over half a century ago, modelling and simulation of human cardiopulmonary physiology emerged as a research methodology, comparable to laboratory experiments and clinical studies. However, teaching fundamental physiological modelling to students and applying these method...

VCF Validation Through Structural, Reference, and Genotype Checks: A Layered Approach to Variant Call Format Quality Control

The Variant Call Format (VCF) is the de facto standard for reporting genomic variants, but its permissive specification and the length of the sequencing-to-variant-calling pipeline leave room for malformed, internally inconsistent, or reference-discordant files to propagate into...