Research works

Pilot study on RECAF (Receptor for Alpha-Fetoprotein) expression in pediatric acute leukemia: insights from flow cytometry analysis

Abstract Background Acute leukemia is the most common cancer in children, highlighting the importance of early diagnosis. RECAF is an AFP receptor that is abnormally re-expressed in various malignant tumors, serving as a promising biomarker for tumors. Aim This study aimed to ass...

Data driven selection of consensus docking pipelines for structure based hit identification

Abstract Structure-based virtual screening (SBVS) is a cornerstone of computer-aided drug design, yet its success depends on selecting a combination of docking tools, scoring function (SF), and ranking strategies. MolDockLab addresses this challenge with an automated, data-driven...

Sustainable Waste-Derived Mineral–Carbon Composites as Reusable Sorbents for Solid-Phase Extraction of Selected Organophosphorus Pesticides from Water

Organophosphorus pesticides (OPs) are persistent environmental contaminants requiring monitoring in aquatic ecosystems. In this study, four novel mineral–carbon composites (K-HNT, K-C-HNT, D-HNT, and D-C-HNT) were synthesized via thermal treatment at 800 °C from halloysite nanotu...

Technical Efficiency and Its Determinants Among Smallholder Soybean Farmers in Mozambique

Mozambique has prioritized soybean within its agricultural strategy, yet smallholder yields remain far below attainable levels and the share of that shortfall attributable to inefficient use of existing inputs has not been quantified. This study estimates farm-level technical eff...

Long Intramural Left Coronary Artery Confined to the Left Sinus of Valsalva with Diastolic Deformation: A Case Report

Abstract Background Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital anomaly. The most frequently reported and surgically treated form involves origin of a coronary artery from the opposite sinus that follows an interarterial course, often termed “maligna...

Quinine modulates PD-L1 and STAT3 in MCF-7 cells: An in silico and in vitro study

Programmed death-ligand 1 (PD-L1) overexpression in cancer cells is linked to immune escape and tumor progression, with signal transducer and activator of transcription 3 (STAT3) as a key transcription factor regulating its expression. This study evaluates the potential of quinin...

Tailoring Vertical Exciton Dissociation Pathways via Hydrogen Bonding for High‐Performance Thick‐Film Organic Solar Cells

ABSTRACT Organic solar cells (OSCs) with thick active layers demonstrate significant potential for scalable roll‐to‐roll manufacturing in industrial applications. However, increasing the active layer thickness triggers unfavorable morphological evolution, compromising vertical ex...

Extinction debt and colonization credit in conservation science

Extinction debt and colonization credit describe the delayed impacts of environmental change on biodiversity, yet their significance largely remains unrecognized by those shaping conservation efforts. To address this gap, we conducted a systematic review of 127 empirical studies...

Evaluation of von Willebrand Factor Antigen as a Prognostic Marker of Major Adverse Cardiac Events in Acute Coronary Syndrome: A Prospective Observational Study

BACKGROUND: Acute coronary syndrome (ACS) is a major global cause of morbidity and mortality. Early identification of high-risk patients is crucial for guiding treatment. Von Willebrand factor (VWF) antigen, a marker of endothelial activation and platelet adhesion, plays a role i...

The perforation triad as a recognition-and-response pattern for balloon- or stent-related Ellis II–III coronary artery perforation during percutaneous coronary intervention

OBJECTIVE: Coronary artery perforation (CAP) is a rare but potentially catastrophic complication of percutaneous coronary intervention (PCI). We describe a prespecified candidate recognition pattern - the perforation triad - that may help operators identify an evolving perforatio...

Ustekinumab as an Effective Therapeutic Option in Papillon–Lefèvre Syndrome: Long‐Term Follow‐Up

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive genodermatosis characterized by palmoplantar hyperkeratosis and severe periodontitis, leading to premature loss of both primary and permanent teeth, and treatment responses are often unsatisfactory. We report a 20-year...

Atomistic simulation of crystal–melt coexistence interfaces under tangential flow

Fluid motion is ubiquitous in solidification, yet its atomistic influence on the immediate solid-liquid interfacial region remains difficult to quantify. Here, we develop an atomistic simulation framework for maintaining solid-liquid coexistence interfaces under imposed tangentia...

Mixing Mechanism and Geometric Effects of Elbows in Offshore Hydrogen-Blended Natural Gas Pipelines

Leveraging existing subsea natural gas pipelines for hydrogen blending offers a practical route for offshore low-carbon energy transport. However, traditional T-pipes require long distances to achieve uniform mixing conditions, raising the risks of stratification and hydrogen emb...

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

ABSTRACT Afterglow luminescence probes are limited by (i) a lack of new afterglow scaffolds; (ii) a dependence on initial external light activation, and (iii) aggregation‐caused quenching. Herein, we demonstrate for the first time that Ir(III) complexes of general formula Ir(C^N)...

Bioactive Phytochemicals from Artocarpus integer Leaves Improve Bone-Related Outcomes in Ovariectomized Rats: An Integrated LC–HRMS, Network Pharmacology, and Experimental Study

Background: Osteoporosis is a multifactorial skeletal disorder characterized by reduced bone mass, impaired bone remodeling, and an increased risk of fractures, particularly under estrogen-deficient conditions. Artocarpus integer (Thunb.) Merr. contains prenylated flavonoids and...

Global research trends in ecosystem health assessment for nature-based solutions using scientometric analysis

Human survival depends on ecosystems, which are an essential component of the earth’s environment. Researchers and professionals are increasingly interested in ecosystem health issues and their nature-based solutions, but disparities persist. A total of 1273 research articles wer...

TypA Interacts with ExsA to Suppress Type III Secretion System in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a nosocomial pathogenic bacterium that causes a wide range of human infectious diseases. The type III secretion system (T3SS) serves as a key virulence determinant underlying the pathogenesis of this bacterium in acute infections. As the master transcrip...

A Lightweight Satellite Orbit Anomaly Detection Method Based on Peak-AAE and Its Edge Deployment

The detection of orbital anomalies is of critical importance to the safe operation of on-orbit spacecraft. Existing methods often rely on manually engineered features and are constrained by the limited computational resources of satellite equipment. This paper proposes a lightwei...

Coordinated Control of Supercapacitors and Hybrid Electric Vehicles for Frequency Regulation in Renewable Power Grids Considering Communication Delays

Integrating renewable energy sources into modern power grids enhances sustainability but reduces the inherent inertia provided by synchronous generators, leading to larger frequency fluctuations and degraded dynamic stability. To address this issue, this paper proposes an advance...

Hourly Dynamic Emission Factors and Integrated Optimization of Electricity Market Prices in Grid-Connected Photovoltaic Systems: Sensitivity Analysis Under Sales Quotas and Decarbonization Scenarios

This study develops a single-level energy management optimization model that evaluates hourly electricity market data and hourly dynamic emission factors (DEF) within a grid-connected photovoltaic (PV) system. The model uses hourly PV production data for 2025, hourly market clear...