Research works

Discontools supplement Mycoplasma hyopneumoniae infections in pigs: update and knowledge gaps

This manuscript reviews current knowledge on Mycoplasma hyopneumoniae , the primary agent of enzootic pneumonia in pigs, integrating advances in epidemiology, pathogenesis, immunity, diagnostics, and control. The pathogen is globally endemic, with transmission driven mainly by di...

Brucella abortus RB51 vaccination: a comprehensive systematic review of safety, efficacy, and global field outcomes (1990–2025)

Brucella abortus strain RB51 is a live attenuated rough vaccine developed to overcome the serological interference of conventional smooth vaccines. Since replacing strain S19 in the United States (1996) and globally thereafter, RB51 has been promoted as a DIVA (Differentiating In...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...

Differential genomic architecture of a ligand-receptor pair in humans and commonly used model organisms

The neuropeptide signaling pathway is vital for the physiology and behavior of multicellular organisms. This pathway is mediated by ligand-receptor binding, wherein neuropeptides (NPs) are often released from neurons, while their receptors (NPRs) are ubiquitously expressed in bot...

Fracture morphology guides the selection of closed versus open reduction in straddle fractures: outcomes of an indication-based treatment strategy

To identify fracture characteristics associated with the selection of closed reduction (CR) or open reduction (OR) for anterior pelvic ring fixation in patients with straddle fractures and to evaluate the radiographic, functional, and complication outcomes following an indication...

Dance Emotion-Related Performance Training System Based on Multimodal Perception and Knowledge Graph

As a comprehensive art form integrating body movements, music rhythm, and emotional expression, dance has unique value in cultivating emotion-related competencies. However, traditional training methods have obvious deficiencies in objective assessment and personalized guidance. T...

Copper as a central element critical to interkingdom interactions within a polymicrobial wound environment

Abstract Staphylococcus aureus is a global health concern, estimated to cause over one million deaths each year. To colonise and survive in humans, S. aureus must overcome the host immune system and compete with other native and invading microorganisms. As a frequent coloniser of...

Psychedelic-informed Therapeutics and Functional Decoupling: Toward Experience-independent Rapid-acting Antidepressants

Major depressive disorder remains a leading cause of global disability, and many patients show limited response to conventional antidepressants.Increasing evidence suggests that a substantial subgroup exhibits chronic low-grade inflammation, which may constrain synaptic plasticit...

Directed Computer-Assisted Certification of a Local Order-10 Operator-Chain Corridor on the Real Interval 5 ≤ s ≤ 14.25 via a Fixed Uniform b₁ Remainder Coefficient, Proof-Preserving Critical-Block Adaptation, and Panel-Aligned Derivative-Group Enclosures

Abstract This preprint update presents a directed computer-assisted certification of strict positivity and corridor inequalities for a constructed order-10 real-parameter operator chain on the local interval 5 <= s <= 14.25. Version v1.1 extends the published v1.0 certificate fro...

AI collaboration and quality of work life: a dual perspective of hotel employees’ perceptions

Purpose The growing prevalence of artificial intelligence (AI) integration in hotel services underscores the urgency of promptly analyzing hotel employees’ appraisals on AI collaboration. Drawing from the cognitive appraisal theory (CAT), we developed a dual-path model linking em...

Menopause and Alzheimer’s disease: can hormone replacement therapy modify the risk? A narrative review

Alzheimer’s Disease (AD) prevalence and lifetime risk are higher in women than men. This led to the hypothesis that menopause, with its associated changes in female hormone homoeostasis, may be an AD risk factor modifiable by hormone replacement therapy (HRT). However, HRT is not...

Energy Shocks, Sovereign Capital Structure, and Impacts on Blue Economy Investment", "Managing Sovereign Debt under Energy Shocks: Fiscal Stability and Policy Intervention

Global energy shocks have become a significant challenge for governments by increasing fiscal pressure and affecting sovereign debt sustainability. Fluctuations in oil, natural gas, and electricity prices influence inflation, government revenues, public expenditure, and economic...

Safety and reproductive performance in sows after vaccination: a randomized controlled trial

Abstract Although reproductive vaccines are essential in swine herd health programs, evidence on their safety across different physiological stages remains limited. This study evaluated the clinical and reproductive safety of Porcilis ® EPL in sows and gilts under commercial fiel...

Enhancing the WAS physical hydrological model and integrating machine learning and residual decomposition to improve runoff simulation performance in the cold region of the Taoerhe River Basin, Northeast China

Study region: The Taoerhe River Basin, located in Northeast China. Study focus: Physical hydrological models still have limitations in representing runoff processes in seasonally frozen semi-arid basins. This study improved runoff simulation through physical model modification an...

Endothelial regulators in the infrapatellar fat pad of osteoarthritis revealed by integrative multi-omics and genetic causal inference

Osteoarthritis (OA) is a multifactorial degenerative joint disease involving multiple joint components, including the infrapatellar fat pad (IFP), whose role in OA pathogenesis remains poorly understood. In this study, we employed an integrative multi-omics strategy to delineate...

A Modular Structure for the Collatz Dynamics: Upper Bound and Uniqueness of the 4–2–1 Cycle

This work introduces a modular mechanism for controlling Collatz orbits through two operators: the projection function S(n) and the elevator E(n)=n·64^k. The function S(n) is defined through a complete classification of residues modulo 18 and maps every natural number directly in...

Deep sleep on a light European train: modularity and lightweight, key to profitable night trains

Current night trains pose a challenge to economic efficiency due to ageing vehicles, limited space and high operating costs, among other things. The AliSa project is rethinking European night trains by developing a modular and lightweight sleeping car concept. A coach concept is...

Boiled or not boiled? – D-aspartic acid in bone proteins as proof of a burial “more teutonico”?

Around the 12th/thirteenth century, a burial method called "more teutonico" was used for the remains of high-ranking individuals who had died far from their homeland and had to be brought back for burial. Before transportation, the bodies or body parts were boiled (macerated) to...

Structure of the Crust and upper Mantle in the Palana–Commander Transverse Dislocation Zone (Kamchatka)

Abstract The paper summarizes the results of deep geological and geophysical studies carried out in the Palana–Commander transverse dislocation zone and along its peripheral parts. The paper also presents the methods of field observations and interpretation of deep geophysical re...

A federated privacy-preserving framework for osteoporotic fracture risk assessment over multi-source heterogeneous medical data

Osteoporotic fractures impose a heavy clinical and economic burden, yet conventional risk tools such as FRAX rely on narrow feature sets and cohort-specific calibration, while richer cross-hospital data remain locked behind privacy and regulatory walls. We propose ADP-FedRE, a fo...