Research works

Gold Nanourchins Potentiate Intravesical Chemotherapy by Accelerating Drug Internalization within a Short Instillation Window

Abstract Intravesical chemotherapy is a standard adjuvant treatment for nonmuscle-invasive bladder cancer after transurethral resection, but its efficacy is limited by drug exposure resulting from urinary dilution and physiological voiding. Most current delivery strategies aim to...

Paediatric haematopoietic stem cell transplantation research priorities: Results from an international multi‐stakeholder priority setting partnership

Summary Co‐designed research in paediatric HSCT is limited. We sought to determine research priorities which represent the shared priorities of patients, parents, carers and healthcare professionals (HCP) within Australia, New Zealand, the Netherlands and the United Kingdom. An i...

Clinical performance of obstetric antiphospholipid syndrome classification criteria: an ambispective cohort study

Abstract Objectives To evaluate the clinical performance of the 2006 Sydney and 2023 ACR/EULAR classification criteria for obstetric antiphospholipid syndrome (OAPS), compare subsequent pregnancy outcomes across classifications and develop a supplementary classification method to...

EuroMillions Breakthrough Mining — 10404 Sources, 101385 Leads Extracted — E8 Intelligence Research

Mined 10404 lottery+quantum breakthroughs. Extracted 101385 leads across 13 categories. 97700 high-value leads found. Categories: {"CORRIDOR": 8865, "FORMULA": 8611, "GEOMETRIC": 1714, "FORWARD_ATTEMPT": 9317, "QUANTUM": 9569, "TIMING": 654, "CELESTIAL": 8676, "GEMATRIA": 9096, "...

EuroMillions Breakthrough Mining — 10415 Sources, 101478 Leads Extracted — E8 Intelligence Research

Mined 10415 lottery+quantum breakthroughs. Extracted 101478 leads across 13 categories. 97793 high-value leads found. Categories: {"CORRIDOR": 8874, "FORMULA": 8618, "GEOMETRIC": 1717, "FORWARD_ATTEMPT": 9328, "QUANTUM": 9580, "TIMING": 656, "CELESTIAL": 8683, "GEMATRIA": 9103, "...

Seroprevalence of Peste des Petits Ruminants Virus Antibodies and Associated Factors in Small Ruminants Sampled Around Protected Wildlife Areas in Pakistan

Peste des Petits Ruminants (PPR) threatens small-ruminant production in Pakistan, particularly where livestock grazing overlaps with wildlife habitats. In this exploratory cross-sectional study (January–June 2024), 1939 sera from goats (n = 1327) and sheep (n = 612) in 56 herds,...

Testing the dimensionality of public attitudes toward artificial intelligence

Public opinion about artificial intelligence (AI) is increasingly measured and invoked in debates about AI governance, yet heterogeneous survey items are often interpreted as indicators of one underlying attitude. Using a weighted survey of registered voters in the U.S. state of...

Relation-aware dynamic knowledge subgraph enhanced large language models for medical multiple-choice question answering

Medical multiple-choice question answering requires models to simultaneously understand question semantics, candidate-answer differences, and structured relations among medical entities in complex clinical contexts. To address the limitations that existing knowledge-enhanced meth...

Cluster‐based decentralized transformers for cyberattack detection and resilient recovery in integrated process networks

Abstract Highly integrated process systems are vulnerable to adversarial cyberattacks that can corrupt sensor measurements, destabilize closed‐loop operation, and propagate across interconnected units. To address these challenges, this study presents decentralized transformer‐bas...

Falsification tests distinguish frequency-aligned separation from α-lactose-specific detection in processed continuous-wave terahertz pellet spectra

Abstract Low-amplitude features near known absorption bands may be interpreted as analyte detection, although pellet and reference effects can generate similar structures. Using a previously described continuous-wave terahertz platform, we prepared α-lactose-containing and matrix...

Italian validation and exploratory measurement invariance of the food addiction symptom inventory (FASI)

Abstract Background The Food Addiction Symptom Inventory (FASI) is a clinician-administered semi-structured interview developed to assess addiction-like eating behaviors related to ultra-processed food consumption, but a validated Italian version is unavailable. This study aimed...

Magneto-mechano-electrochemical fiber for deformation-resilient and smart electronic textiles

Electronic textiles represent a transformative platform for integrating technology into daily wear, yet their development has been undermined by a fundamental challenge: the conflicting requirements between mechanical deformation for functionality and structural stability for per...

Negative‐Thermal‐Expansion Strategy Enables Hard Carbon With Tuned Heat/Strain Tolerances for Sodium Storage

ABSTRACT The thermal/stress runaways pose a risk to the safety and industrialization of sodium‐ion battery (SIB), which hence requires external management equipment. Actually, the thermal/stress generation originates from the repetitive Na + intercalation within carbon interlayer...

Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping

Analyses routinely conducted in both fundamental research and biomedical studies often report aggregate signals derived from heterogeneous mixtures of cells. These mixtures reflect the intrinsic anatomical and functional complexity of the tissues and organs from which they are de...

When Risk Measures Disagree: Evaluating Risk Under Non-Normal Returns

This paper explores how statistical measures of risk, categorized as standard, downside, or market sensitivity measures, perform when returns are not normally distributed. Many investment theories, such as Modern Portfolio Theory, assume an approximation of normality. The point o...

A flag-curve proof of an original-side pedal-area invariant

For a noncircular ellipse and a proper nested confocal elliptical caustic whose primitive least billiard period is divisible by four, the signed original trajectory area times the signed area of its original-side-line pedal polygon is independent of phase for every fixed finite r...

Comparative study of PARSEC, CST, and Bezier-PARSEC (BP3333) for GA-driven wind-turbine airfoil design

Efficient aerodynamic design of wind-turbine blade sections relies on robust shape parameterization coupled with powerful optimization. This study benchmarks three leading schemes-PARSEC, Class/Shape Transformation (CST), and Bezier-PARSEC 3333 (BP3333) – within a genetic algorit...

Exploring hydrogen production from plastic waste for urban transportation in Hong Kong and its environmental impact mitigation: integrating dynamic material flow analysis and life cycle assessment

Plastic waste to hydrogen technology offers a sustainable clean energy pathway while reducing landfill and incineration burdens. However, its feasibility as a feedstock for urban mobility decarbonization at the city scale remains largely unexplored. Hong Kong, as a densely popula...

Septic arthritis attributed to a spider bite — a case report and review of the literature

Individuals who travel to tropical or subtropical areas are exposed to various infectious, environ-mental, and climatic risk factors, as well as traffic accidents, security problems, natural disasters, and direct contact with potentially dangerous plants or animals. Accidental bi...

ATR-FTIR Spectroscopy Combined with Machine Learning Enables Detection of Schistosomiasis-Associated Biochemical Signatures in Human Serum

Abstract Schistosomiasis, caused by Schistosoma mansoni, remains a major public health burden in endemic regions, demanding rapid and reliable diagnostic strategies. Here, we report a label-free diagnostic platform based on attenuated total reflectance Fourier transform infrared...