Research works

Chimeric Antigen Receptor T‐Cell Therapy in T Cell/Histiocyte‐Rich Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of B-cell non-Hodgkin lymphoma with an aggressive clinical course and poor prognosis in the case of relapsed or refractory (r/r) disease. Recently, anti-CD19 chimeric antigen-receptor (CAR) T-cell therapy ha...

From Chronic Infection to Microbial Imbalance: Rethinking Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) has traditionally been viewed as a chronic inflammatory disease in which microbial factors are implicated. However, increasing evidence suggests that CRS may be better understood as a disruption of sinonasal microbial homeostasis rather than as a chro...

The Epistemic Substitution Error: Why Accurate Algorithmic Decisions Can Still Be Illegitimate

Institutions increasingly rely on algorithmic systems to assess people, allocate opportunities, and justify consequential decisions. Existing debates often ask whether these systems are accurate, fair, transparent, or explainable. This article identifies a distinct philosophical...

Relocation, laser dusting and suction (RELOADUS): An international collaborative observational study for laser management to prevent strictures of symptomatic impacted upper ureteric stones

Background Ureteric stricture formation following ureteroscopy and laser management of stones is known. Objective To evaluate the feasibility, safety, stone clearance outcomes and rate of upper ureteric stricture formation after implementation of the Relocation, laser dusting and...

Numerical Simulation of Spatial Distribution Characteristics of Hazardous Gas Clouds from Leakage at a Hydrogen-Blended Natural Gas Distribution Station

Abstract Blending hydrogen into natural gas pipelines is widely regarded as a promising transitional pathway for large-scale H2 transport; however, it inevitably increases the risk of leaks and explosions at urban distribution stations. This computational fluid dynamics (CFD) stu...

Field evaluation of biodegradation of boscalid and kresoxim-methyl in grape leaves by plant growth-promoting rhizobacteria

This study investigated the potential of plant growth-promoting rhizobacteria (PGPR) to enhance the dissipation of boscalid and kresoxim-methyl residues in grape leaves under field conditions. The experiment was conducted in a vineyard in Tokat, Türkiye, using the ‘Narince’ ( Vit...

Acute pancreatitis does not end at discharge: the forgotten risk of post-pancreatitis diabetes

Abstract Acute pancreatitis (AP) is traditionally considered an acute inflammatory illness from which patients recover once pain resolves, organ dysfunction improves, and the underlying cause is addressed. However, pancreatic recovery may not be complete at discharge. Increasing...

Exploring uncertainties in melanoma management: a Spanish multidisciplinary Delphi consensus

Abstract Purpose Melanoma is a highly metastatic tumor responsible for 90% of skin cancer deaths. Despite established clinical guidelines, certain areas of its management in Spain remain heterogeneous, particularly in complex scenarios such as neoadjuvant therapy, metastatic sequ...

Improving allergic rhinitis symptoms through nutrition as an adjunct: a systematic review and meta-analysis on the efficacy of dietary supplements

Dietary supplements are increasingly explored as adjunctive strategies for allergic rhinitis (AR). This systematic review and meta-analysis evaluated the efficacy of dietary supplementation in improving AR symptoms and explored potential underlying mechanisms. A systematic PubMed...

Effects of a Chilean Hazelnut-Supplemented Diet on Oxidative Stress and Cytokine Expression in PBMCs of Hypercholesterolemic Adults: A Randomized Controlled Trial

Background/Objectives: Hypercholesterolemia is characterized by alterations in lipid metabolism, oxidative stress, and inflammatory status. Nuts have been shown to mitigate these alterations; however, limited evidence is available regarding their effects in the Chilean population...

Coupled Design of In-Plane Heat Spreading and Boundary-Tailored Nonuniform Discrete-Heater Geometry for Composite Electrothermal Ice-Protection Systems

Discrete heating and spatially varying convection jointly determine temperature distributions in composite electrothermal ice-protection structures. A two-dimensional transient multilayer model is used to examine the coupling between in-plane heat spreading and discrete heater ge...

Make Shapes and Signals Meet: A Gentle Guide to BCPD and DET

Make Shapes and Signals Meet is an illustrated, beginner-friendly guide to BCPD and DET. BCPD aligns shapes using point locations, while DET also uses signal information—such as image intensities, audio amplitudes, or gene-expression features—to guide registration. The guide intr...

A novel fault diagnosis model synergizing weighted health indicator with feature-enhanced Transformer for wind turbine bearing

Fault signals of wind turbine bearings have nonlinear and non-stationary characteristics, and the fault features are weak under actual noise interference conditions, leading to difficulties in fault feature extraction and identification. This paper proposes a novel fault diagnosi...

Take a Proactive Approach to Electrical Maintenance

Unplanned electrical failures can disrupt operations, damage equipment, and create safety risks. A structured maintenance program helps water and wastewater utilities identify problems early, prioritize critical assets, and reduce the likelihood of costly outages.

The Missing Interface: Why Complex Projects Fail Where Nobody Is Looking

Complex projects are assumed to be coordinated when their documents are aligned. This article argues that the assumption fails in a specific and costly way. Projects often fail at their human interfaces, the boundaries between people, teams and organisations where shared understa...

The Role of Identity-Related Issues in Partisan Shifts Among White Americans, 2016–2020

ABSTRACT During the 2020 US presidential election, identity-related issues—immigration, racial justice, and white identity—were central to public discourse. This study examines how these issues shaped shifts in partisanship among white Americans who changed their affiliation from...

A community-derived framework for designing and evaluating safe physical activity opportunities for transgender and gender diverse people

Background Transgender people experience barriers to participating in physical activity, many of which relate to concerns about safety, discrimination, and access to affirming environments. Although research has identified these barriers, there are few practical tools to guide or...

Time evolution of corrosion-induced cracking in reinforced concrete under chloride exposure

The time-dependent initiation and propagation of corrosion-induced cracking in reinforced concrete (RC) was investigated, considering key material and geometric parameters. Accelerated corrosion tests were conducted on RC pull-out specimens with varying concrete compressive stren...

From Chronology to Physiology: A Critical Translational Assessment of Artificial Intelligence for Precision Healthspan Measurement

Healthspan, the period of life free from major chronic disease and disability, is a central geroscience outcome, yet its prediction remains difficult due to its multidimensional and heterogeneous nature. In this review, we synthesize advances in artificial intelligence (AI) for p...

The Eight-Triangle Alternating-Pivot Square-Root Ribbon: An Open Mathematical Challenge

The Weaver & Wit — Open Mathematical Mischief, No. 1. We propose a chain of right triangles with unit legs and successive hypotenuse lengths √2, √3, … . After each group of eight triangles, the construction swaps which endpoint is the pivot and reverses the perpendicular turn. In...