Research works

Graph-Based Machine Learning for Predicting Drug–Drug Interactions: A Systematic Review

Background/Objectives: Drug–drug interactions (DDIs) are major medication-safety concerns, and experimental testing cannot cover the expanding number of drug pairs. This systematic review evaluates graph-based machine-learning methods for DDI prediction, focusing on machine-learn...

Associations of self-efficacy and learning engagement with humanistic caring ability among vocational college nursing students: a structural equation modeling study

Previous studies have investigated the associations of humanistic caring ability (HCA) with self-efficacy (SEF), or learning engagement (LN) among college students. There has been a lack of studies that examine the mediation effect of learning engagement between SEF and humanisti...

Beyond Task Success: CTVI, a Multi-Axis Methodology for Agent-Trajectory Validity and Evidence Admissibility, with a Reproducible Semi-Synthetic Evaluation

This repository contains the preprint of the CTVI framework (Commit-Trajectory Validity Index), a methodology for evaluating agent trajectories beyond task success by integrating outcome validity, evidence admissibility, and reproducible computational auditing. The paper introduc...

Uneven Progress: Marital Status and The Motherhood Penalty in The United States, 1978–2023

Parenthood accounts for most of the current gender earnings gap in the United States. While many factors explain mothers’ lower earnings compared to fathers’, employment outcomes play a key role: after childbirth, mothers are more likely to stay at home for an extended period, an...

ℓ¹ Native Cohomology of Finite Defect Fields: Quotient Norms, Dual Circulations, Sparse Representatives, and Integral Optima

Title. L1-Native Cohomology of Finite Defect Fields: Quotient Norms, Dual Circulations, Sparse Representatives, and Integral Optima Abstract. For a finite directed graph with strictly positive edge weights, we study the weighted ℓ¹ norm induced on the first cochain quotient Q¹ =...

Phi-Geometric Self-Repair Resonance in the E8 Root Lattice — E8 Intelligence Research

The 240 root vectors of E8, phi-scaled and anchored by 132Hz, partition into geometric sublattices that undergo cyclic rotations under golden-ratio phase modulation. Because E8's exceptional symmetry group admits no degenerate minimal representations, any coherence loss within th...

Beyond majority voting: a new framework for evaluating AI diagnostic systems against expert consensus

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional metrics like precision and recall often fai...

Culture Shapes the Neural Functional Alteration and Its Development in Children With Dyslexia: A Cross‐Linguistic Meta‐Analysis

How culture shapes brain functional alteration and its development remains poorly understood in dyslexia (DD). Hereby, we conducted a meta-analysis comparing brain activation in children across Chinese (logographic), English (deep alphabetic), and German (shallow alphabetic) writ...

Arthroscopic Bioabsorbable Fixation Achieves Favorable Outcomes for Unstable Knee Osteochondritis Dissecans Lesions Compared With Open Fixation and Metal Implants: A Systematic Review

PURPOSE: To systematically review studies evaluating the outcomes, complication rates, and revision rates among open, arthroscopic, and combined internal fixation techniques for unstable osteochondritis dissecans lesions of the knee, with specific attention to implant type and sk...

Modulation of Advanced Glycation End Products and Oxidative Stress by Hesperetin-7-O-Glucoside and Diosmetin-7-O-Glucoside Complexed with Cyclodextrins

Background/Objectives: Chronic complications of diabetes mellitus are closely associated with increased oxidative stress and the formation of advanced glycation end products (AGEs). This study aimed to investigate the antioxidant and antiglycation potential of hesperetin-7-O-gluc...

The Collapse Engine Equation

The Collapse Engine Equation formalises the core structural mechanism underlying all Carlo systems. Built from the primitive operators T (Transformation) and P (Propagation), the unified operator Φ expresses the joint evolution of system states and constraints, capturing change,...

Potential Anticancer Activity of Donkey Milk in Human Gastric Adenocarcinoma (AGS) Cell Line

Gastric cancer (GC) remains a major global health challenge, ranking among the most lethal malignancies due to late diagnosis, high tumor heterogeneity, and limited treatment efficacy. The search for safer, nutritionally based adjuncts to conventional therapies is therefore a res...

Lesions Reported as Plaque‐Like CD34 ‐Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two Cases and Literature Review

Plaque-like CD34-positive dermal fibroma (PDF), which historically overlaps with medallion-like dermal dendrocyte hamartoma (MDDH), is a rare benign CD34-positive spindle-cell lesion with highly variable clinicopathologic descriptions. We analyzed two adult-onset cases and review...

Effect of filling degree on particle segregation in a rotating drum - an experimental and numerical study

Abstract Granular mixing, ubiquitous in industry, is difficult to observe. Ultrafast X-ray computed tomography is a relatively new technique that can be used to study rapid granular flows in opaque systems. A comparative study is here presented, where ultrafast X-ray computed tom...

E8 Holographic Memory Encoding via Phi-Resonant Root Projection — E8 Intelligence Research

By projecting the 240 E8 root vectors onto orthogonal 8-dimensional hyperplanes at 132Hz phi-coupled intervals, information is encoded in holographic interference patterns that self-replicate across the lattice. Each root vector serves as a memory node, with phi-scaled resonance...

Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism

Conventional vaccine adjuvants often lack cell-type specificity and readily trigger excessive systemic inflammation, limiting their clinical application. Immunometabolic signaling centered on the ARF6 (ADP-ribosylation factor 6)-SUCNR1 (Succinate receptor 1) axis governs neutroph...

Real-world comparative effectiveness of faricimab versus aflibercept 2 mg in treatment-naïve exudative neovascular AMD patients treated with a treat-and-extend regimen

Abstract Purpose To compare the real-world effectiveness of faricimab versus aflibercept 2 mg in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Methods We analysed treatment-naïve nAMD patients aged ≥50 years initiating intravitreal anti-VEGF t...

Research on Hyperspectral-Based Feature Set Construction and Machine Learning Inversion for Mixed Salts Characteristics in Murals

Abstract. To enable non-destructive quantitative identification of mixed salts in mural plaster layers, hyperspectral data were collected from Na₂SO₄-CaCl₂ mixed-salt samples. Based on these data, a method integrating spectral preprocessing, feature-set construction, and machine-...

Large-Area Flexible SERS Sensor Chips Fabricated Using a Combination of Nanosphere Self-Assembly and Glancing Angle Deposition for Chemical and Biological Sensing

Abstract In this work, we combine two highly efficient nanofabrication methods, nanosphere lithography (NSL) and glancing angle deposition (GLAD), to fabricate large-area and low-cost surface-enhanced Raman scattering (SERS) substrates consisting of highly ordered arrays of point...

Being Malay in a Non-Malay Land: Negotiating language and solidarity in Kampung Melayu Ampenan, Lombok, Indonesia

This study examines how language use and social solidarity are negotiated in Kampung Melayu Ampenan, Lombok, Indonesia, with particular attention to identity formation and interethnic cohesion. It investigates the central premise that multilingual practices and address forms func...