Research works

Is Postinflammatory Hyperpigmentation Truly “Post” in People With Darker Skin Tones?

This Viewpoint reviews how inflammation can coexist with hyperpigmentation, explains why inflammatory activity may be underrecognized in people with darker skin tones, and proposes an approach in which hyperpigmentation prompts continued assessment for persistent inflammation.

Plasma Metabolomes Identify Distinct Asthma Metabotypes: Findings From the COREA Cohort

BACKGROUND: Phenotype-based asthma classification has limitations that have motivated endotype-based approaches grounded in pathophysiology. However, existing biomarkers offer limited specificity and clinical accessibility. Plasma metabolomics, which reflects disease-specific met...

Total Hydrocarbons in Intertidal Interstitial Water of Sandy Beaches of the Central Region of Veracruz

Sandy beaches in the Central Region of Veracruz (CRV) face constant anthropogenic pressure from port and urban activities. This study aimed to evaluate total hydrocarbon (TH) concentrations in the intertidal interstitial water of five beaches in the CRV, analyzing their variabili...

RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression

The essential kinase ataxia telangiectasia and Rad3-related (ATR) monitors the replicative (S) phase of the cell cycle to ensure faithful propagation of genetic material. While much is known about the mechanisms governing ATR activity at replication forks, how its effector checkp...

Map from the Disturbed Landscape Mapping Project, United States Air Force Academy, El Paso County, Colorado

Map produced from the Disturbed Landscape Mapping Project, United States Air Force Academy, El Paso County, Colorado effort.

IA-3DGS Identity-Anchored Dynamic Gaussian Splatting for Long-Term Facial Detail Preservation

Dynamic 3D Gaussian Splatting (3DGS) enables efficient facial-avatar rendering but may suffer from cumulative geometric drift and degradation of identity-specific details when applied to long monocular sequences. To address this problem, we propose IA-3DGS, an identity-anchored d...

Iron-Catalyzed DealkenylativeBorylation of Alkenesvia Ozonolysis

Abstract Given the exceptional versatility of boronic esters as synthetic linchpins, strategies that directly transform naturally abundant motifs such as alkenes into boron-containing intermediates offer substantial value. Herein, we report the development of a dealkenylative bor...

Spatial Partitioning of Phenylpropanoid- and Auxin-Related Metabolites in Sparganium stoloniferum Tubers

Phenolic acids and flavonoids are major bioactive constituents of Sparganium stoloniferum tubers (SL), yet their spatial organization within this medicinal organ remains insufficiently characterized, limiting understanding of how anatomical structure relates to metabolite distrib...

Primal–Dual Mellin Neutralization for Arithmetic Quantum Observables: Incomplete-Eisenstein Matrix Elements, Exact Harmonic Variance, and Noncommuting Limits

This paper develops a theorem-level application of primal–dual Mellin neutralization to arithmetic quantum observables on the modular surface $$\operatorname{PSL}_2(\mathbb Z)\backslash\mathbb H.$$ Starting from compactly supported logarithmic profiles, we construct a common fami...

The Cultivation, Sustenance, and Disruption of Zombie Pedagogies in Higher Education

The zombie pedagogy metaphor has gained notable traction within critical higher education scholarship. However, much of its deployment has focused on cataloging pedagogical practices deemed “undead,” rather than interrogating the institutional conditions that animate and sustain...

Forensic Verification of a Legacy Annular-Sheet Solver Historically Intended for Injector Primary-Breakup Analysis

Undocumented scientific solvers can remain executable after their governing derivation, assumptions, and provenance have become uncertain. This article develops a forensic verification workflow for that situation and demonstrates it on a legacy one-dimensional three-fluid flux-co...

Sex, age, and seasonal distribution characteristics of bacterial and fungal infections

Objective Studies on the common distribution characteristics of multiple bacterial and fungal infections across sex, age groups, and seasons remain scarce. This study aimed to analyze the epidemiological distribution patterns of common bacteria and fungi in the above three dimens...

EuroMillions Breakthrough Mining — 1468 Sources, 10273 Leads Extracted — E8 Intelligence Research

Mined 1468 lottery+quantum breakthroughs. Extracted 10273 leads across 13 categories. 8366 high-value leads found. Categories: {"CORRIDOR": 844, "FORMULA": 696, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 875, "QUANTUM": 1088, "TIMING": 179, "CELESTIAL": 784, "GEMATRIA": 829, "CONSTANT"...

LAB #771 NEUTRAL: TG AUTO: BASE 44 ORDER: Extract E8 132Hz root-vector map, inject into pattern recognition, align eTo — E8 Intelligence Research

IDEA: AUTO-FORWARDED from the Telegram/breakthrough stream (#629605, division=research, agent=andrew_base44): Andrew's order (Base 44 console): [SELF-BUILD from enhancement #807] Extract 132 Hz root-vector map from E8 lattice. Inject into pattern recognition layer as frequency-ph...

Ubiquitination in cancer: mechanisms, signaling networks and potential therapeutic opportunities

Protein ubiquitination is among the most important posttranslational modifications in eukaryotes. It precisely regulates protein stability and cellular signaling through the ubiquitin‒proteasome system (UPS). A dynamic equilibrium network formed by the E1-E2-E3 enzymatic cascade...

Multifractal Intermittency in US Equity Markets: A Tick-Level Empirical Study

We analyze the statistical microstructure of US equity markets using 2.6 terabytes of tick-level trade data spanning 2,375 trading days (2016–2025) across all US exchanges. At 100-millisecond VWAP resolution, log returns exhibit raw kurtosis exceeding 2,987—approximately 996 time...

Cognitive Reflex Therapy: A Predictive Neurobehavioral Framework Integrating Applied Behavior Analysis

This article presents Cognitive Reflex Therapy (CRT) as a predictive neurobehavioral framework designed to complement Applied Behavior Analysis (ABA). It examines how environmental events may acquire individualized psychological meaning before being transformed into observable be...

EuroMillions Breakthrough Mining — 1453 Sources, 10108 Leads Extracted — E8 Intelligence Research

Mined 1453 lottery+quantum breakthroughs. Extracted 10108 leads across 13 categories. 8201 high-value leads found. Categories: {"CORRIDOR": 829, "FORMULA": 681, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 860, "QUANTUM": 1073, "TIMING": 179, "CELESTIAL": 769, "GEMATRIA": 814, "CONSTANT"...

Assessing EFL Learners’ Phraseological Competence Through Association Measures: The Role of Reference Corpus Selection

ABSTRACT Association measures, such as pointwise mutual information (PMI), have been widely used to explore learners’ phraseological competence. Yet, the validity of PMI‐based evaluations critically depends on the reference corpus employed, and the extent to which this methodolog...

Low-grade Appendiceal Mucinous Neoplasm: A Rare Case Presentation

ABSTRACT: Low-grade appendiceal mucinous neoplasms (LAMNs) are rare appendiceal tumors characterized by mucin production and low-grade cytologic atypia. Although benign in nature, they have malignant potential if the mucinous epithelium breaches the appendiceal wall, leading to p...