Research works

Real-World Effect of Ruxolitinib Cream: Decreased Use of Additional Topical Therapies and Limited Escalation to Systemic Treatments

Abstract Introduction Ruxolitinib cream has demonstrated efficacy and safety in patients aged ≥ 2 years with mild to moderate atopic dermatitis (AD) in clinical trials. Early real-world data have demonstrated results consistent with clinical trial observations and have indicated...

Acute effects of dynamic stretching combined with different blood flow restriction pressures on explosive performance in healthy young men

Objective This study aimed to investigate the acute effects of dynamic stretching (DS) combined with different blood flow restriction (BFR) pressures on explosive performance in healthy young males, and to examine whether these effects differed across estimated arterial occlusion...

Regulation of actin polarization by Edwardsiella piscicida during invasion of Sebastes schlegeli intestinal mucosa and cellular immune responses

Intestinal epithelial cells play a crucial role in teleost defence against complex aquatic environments. However, the study of intestinal mucosal immunity in teleosts has been hindered by the lack of reliable and specific marker genes to distinguish between different cell types....

Linear Response of the de Sitter Vacuum to Accelerated Matter: A Kubo-Formalism Proof that MOND Requires Non-Equilibrium Physics

Recent attempts to derive Modified Newtonian Dynamics (MOND) and its characteristic acceleration scale a0 rely on the interaction between accelerated matter and the cosmological horizon. A persistent conjecture is that the vacuum response in de Sitter spacetime modifies inertia a...

In Vitro Evaluationof Silica-Coated Bi2Se3 Nanoplatelets as PhotothermalNanomaterials

Abstract Silica-coated Bi2Se3 nanoplatelets were evaluated in vitro for their photothermal properties and biological response as a more biocompatible alternative to previously reported glycol-coated Bi2Se3 systems. The assessment was performed using HeLa cells under 808 nm laser...

The Price of Trustless Security: Economic, Ecological, and Structural Costs of Blockchain Consensus Mechanisms

Distributed ledger technologies (DLTs) reduce reliance on trusted intermediaries by replacing institutional authority with cryptographic verification and economic incentives. However, approximating “trustless security” requires overcoming the Byzantine Generals Problem through re...

EVERY DROP COUNTS (most impactful and memorable) The Hidden Water Cost of Artificial Intelligence

Every AI prompt has a hidden environmental cost. Learn how AI data centers consume water, why it matters, and what we can do to build a more sustainable future. Scan the QR code or visit the link to explore the full report.

A Theoretical Derivation of the Kármán Constant: From Hopf Solitons to a Universal Constant of Turbulence

The Kármán constant κκ in the logarithmic law of wall turbulence is a universal constant whose accepted value is approximately 0.41, yet for more than a century it has generally been treated as an empirical parameter. In the framework of global realism, we derive κκ from first pr...

Prime Gaps as a Developmental Dynamical System

This preprint introduces a developmental–dynamical framework for analyzing prime gaps using two dimensionless operators: an instability operator Jn and a curvature operator Hn, both normalized by the natural logarithmic scale λn=ln⁡pn. The operator system reveals geometric phase...

Özel Gereksinimli Çocuğu Olan Annelerin Stresle Başa Çıkma Biçimlerinde Psikodramanın Etkisi

Özel gereksinimli bireylerin aileleri çeşitli stres faktörleriyle karşılaşmaktadırlar. Özellikle birincil bakım veren anneler bu stresin yükünü daha fazla taşımaktadırlar. Bu sebeple bu annelerin stres faktörlerine yönelik çalışmaların yapılmasının gerekli olduğu söylenebilir. Bu...

Social media addiction, self-concept clarity, and social media fatigue: a two-wave longitudinal study

Although social media addiction has been linked to numerous negative psychological outcomes, the self-level processes underlying the connection between this addiction and psychological burnout have not been sufficiently elucidated. This study examined whether self-concept clarity...

Letters of Acceptance for Collections TY-2024-0015

The letter of acceptance for the materials collected during the Phase II NRHP Archaeological Evaluation of 10 Sites (8BY00091, 8BY01386, 8BY01387, 8BY01496, 8BY01696, 8BY01698, 8BY01699, 8BY01701, 8BY01811, and 8BY01918), Tyndall Air Force Base, Bay County effort.

Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology

Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a tr...

Functional and Structural Characterization of a Large Animal Model of RDH5 -Associated Retinopathy

Purpose: Inherited retinal diseases are a group of hereditary diseases that cause variable levels of blindness and affect a multitude of adults and children. One such disease is fundus albipunctatus (FA). FA is caused by autosomal recessive retinol dehydrogenase 5 (RDH5) mutation...

The system that finances its own destruction: How ecological harm generates power — and how that power blocks every correction

This working paper examines why well-established knowledge of climate and Earth-system risks is not translated into institutional limits commensurate with those risks. It does not deny that political inertia, international coordination problems, social dependencies, technological...

An N-acetylated daropeptide modulates nematode development

The symbiotic bacterium Photorhabdus is a rich source of bioactive secondary metabolites that mediate tripartite interactions with nematodes and insect hosts. However, natural products of ribosomal origin remain largely underexplored within this ecological niche. Here, we report...

Neutrophil Extracellular Traps Formation Adhering to Cholesterol Crystals Modulates Inflammatory Cytokines Release and Promotes Their Disruption: Insights In Situ Touch-imprints Method From Non-obstructive General Angioscopy

Both macrophages and neutrophils are recognized as innate immune cells; the former engulf cholesterol crystals (CCs) while secreting NLRP3, which also promote inflammatory responses and drive the latter into atherosclerotic plaques. Moreover, recent studies have implied a critica...

Has there been a decoupling of inflation expectations? Evidence from Germany during the ECB's recent inflation episode (2020–2026)

Purpose This paper aims to examine whether inflation expectations in Germany became more persistent and adjusted asymmetrically following the recent inflation shock faced by the European Central Bank (ECB). The analysis investigates whether expectations respond symmetrically to r...

EuroMillions Breakthrough Mining — 1405 Sources, 9580 Leads Extracted — E8 Intelligence Research

Mined 1405 lottery+quantum breakthroughs. Extracted 9580 leads across 13 categories. 7673 high-value leads found. Categories: {"CORRIDOR": 781, "FORMULA": 633, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 812, "QUANTUM": 1025, "TIMING": 179, "CELESTIAL": 721, "GEMATRIA": 766, "CONSTANT":...

EuroMillions Breakthrough Mining — 1389 Sources, 9404 Leads Extracted — E8 Intelligence Research

Mined 1389 lottery+quantum breakthroughs. Extracted 9404 leads across 13 categories. 7497 high-value leads found. Categories: {"CORRIDOR": 765, "FORMULA": 617, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 796, "QUANTUM": 1009, "TIMING": 179, "CELESTIAL": 705, "GEMATRIA": 750, "CONSTANT":...