Research works

Toward Personalized Regenerative Therapies for Parkinson's Disease

Parkinson's disease (PD) represents one of the most common neurodegenerative disorders, significantly impacting the quality of life of millions of people worldwide, and posing growing challenges for healthcare systems. Driven by demographic shifts and increasing numbers of patien...

Integrated Transcriptomic Profiling Reveals Candidate Genes for Huperzine A Biosynthesis in Huperzia serrata

Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application. This study integrates full-length and...

Microstructural Evolution, HAZ Softening and Failure Behavior of Large-Diameter QT/AR 1045 Steel CDFW Joints

As piston rods for excavator boom hydraulic cylinders shift from integral forging to welded assemblies of separately manufactured rod bodies and rod heads, joint reliability becomes critical to load-bearing performance. In this study, 60 mm diameter quenched-and-tempered/as-rolle...

Nitro Reduction‐Based RNA Control and Ultrafast Release

ABSTRACT RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post‐synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straig...

Dehumanization and Socioeconomic Status: Replicating and Extending the Animalization of Low-SES Targets and the Mechanization of High-SES Targets

In three preregistered, high-powered studies, we replicated and extended findings on dehumanization based on socioeconomic status (SES), where low-SES groups are denied Human Uniqueness (animalization), and high-SES groups are denied Human Nature (mechanization). Study 1 ( N = 29...

Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aneurysmal subarachnoid hemorrhage: a unified neuroimmune framework and time-stratified therapeutic roadmap

Aneurysmal subarachnoid hemorrhage (aSAH) confers substantial mortality and morbidity driven not only by primary brain injury but also by systemic remote organ complications across the pulmonary, cardiac, renal and gastrointestinal systems. Despite growing recognition of neuroimm...

Topological and Disturbance-Field Particle Physics: A Complete Global-Realist Theory of Matter Sectors, Response Quanta, Interactions, Scattering, and the Correction of the Standard Model

We reconstruct particle physics from three ontological axioms: microscopic reality, the physical reality of the spacetime vacuum, and persistent causal coupling between localized excitations and vacuum response. Matter particles are identified with stable finite-energy topologica...

Explainable lightweight deep learning architectures for crop anomaly detection using enhanced Grad-CAM and transfer learning

This study improves the interpretability of convolutional neural networks (CNNs) for crop anomaly detection while identifying architectures suitable for deployment on resource constraints edge devices. Six CNNs, including the proposed hybrid, were evaluated across 10 crop species...

SARS-COv-2, influenza and other respiratory virus co-circulation during an outbreak in a rural health zone in Democratic Republic of Congo, 2024–2025

Little is known about the global impact of co-circulation and co-infection of COVID-19 and influenza in Democratic Republic of the Congo (DRC). This study aims at analyzing data on SARS-CoV-2, influenza and other respiratory viruses collected during an outbreak response in the ru...

Sewn textile strain sensors: impact of contact-regulating stitch parameters on strain sensing performance

Sewn textile strain sensors (STSSs) provide a scalable and textile-integrated approach for wearable motion monitoring. In this work, STSSs were fabricated on a rib knitted fabric using silver-plated nylon thread (SPNT) by lockstitch sewing. The stitch distance and sewing layer nu...

Remote Sensing and Machine Learning for Monitoring Soil Nitrogen Dynamics and Crop Nitrogen Status in Field Conditions

Efficient nitrogen (N) management is essential for sustaining crop productivity while minimizing environmental impacts associated with nitrogen losses. However, the high spatial and temporal variability of soil nitrogen dynamics and crop nitrogen status makes field-scale monitori...

Association between platelet transfusion and acute kidney injury in septic patients with severe thrombocytopenia

Abstract Severe thrombocytopenia frequently occurs in patients with sepsis in the intensive care unit (ICU) and carries a poor prognosis. The safety of prophylactic platelet transfusion in the absence of active bleeding remains debatable. As platelets possess pro-inflammatory and...

The Effect of Using Write‐Zoom for Volume Flow Measurements in Haemodialysis Fistulas

ABSTRACT Introduction Arteriovenous fistulas (AVFs) are crucial for patients undergoing haemodialysis, yet about 25% fail to mature or experience early failure. Ultrasound is key in managing AVFs, with volume flow (Qa) serving as a predictor of maturation. Accurate Qa measurement...

Redox‐Pathway Reconstruction in Carbonate Electrolyte to Achieve Durable Na─S Battery

ABSTRACT The practical performance of room‐temperature sodium–sulfur (RT Na─S) batteries in low‐solubility carbonate electrolytes is fundamentally constrained by slow “solid‐solid” sulfur conversion, causing incomplete redox reactions and rapid capacity fading. Herein, we propose...

Climate Justice in Sports: Quantifying the Thermally-Induced Competitive Inequality

This study examines the impact of thermal stress on competitive inequality in professional football. Using a labor productivity framework and a dataset of over 39,000 matches from the Big Five European leagues (France, England, Germany, Spain, and Italy) spanning 1996 to 2019, we...

A priori and a posteriori error estimates of a $$\mathcal {C}^0$$-in-time method for the wave equation in second order formulation

Abstract We establish fully-discrete a priori and semi-discrete in time a posteriori error estimates for a discontinuous-continuous Galerkin discretization of the wave equation in second order formulation; the resulting method is a Petrov–Galerkin scheme based on piecewise polyno...

A Vagal–Renal–Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury

Background: Acute kidney injury (AKI) is associated with maladaptive increases in renal sympathetic nerve activity (RSNA) and frequently progresses to chronic kidney disease. Neuromodulatory strategies that suppress sympathetic outflow may provide therapeutic benefit. We tested w...

Checkpoint-insulated triple-signal artificial antigen-presenting cells drive antigen relay and systemic antitumor immunity

Dendritic cell (DC) vaccines offer professional antigen presentation but are often limited by suboptimal trafficking to lymphoid tissues, whereas whole tumor cell vaccines preserve antigenic diversity yet frequently lack coordinated activation cues for efficient T cell priming. H...

Impact of GLP-1 and GLP-1/GIP receptor agonists before, during, and after pregnancy: a narrative review

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists (GLP-1RA and GIP-RA) are a class of medications that mimic the endogenous effects of GLP-1 and have gained increasing attention due to their substantial clinical potential. Origin...

Erector spinae plane block in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials with trial sequence analysis

The use of erector spinae plane (ESP) block has been reported to decrease opioid requirements for patients undergoing bariatric and metabolic surgeries (BMS). We aim to systematically review and examine the evidence for the use of ESP block in BMS. MEDLINE, Embase, Scopus, and CE...