Research works

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...

Boundaries of Machine Interpretation

Boundaries of Machine Interpretation is a bilingual, versioned authorial statement set by Ivan Kotov. Version 0.2 consolidates six connected formulations: the future as a process; doubt versus numerical uncertainty; forgetting versus data loss; empathy versus optimization; subjec...

Failing to Maintain Contact With Probation: Discovering the Reasons Why

A common requirement for individuals on probation is to remain in contact with their probation officer (PO). Failure to do these actions may result in a violation that could lead to a revocation. Further, not knowing one’s whereabouts on probation could create public safety conce...

Toward Permanence Yet Unattainable: A Thermodynamic Interpretive Framework for the Evolution of Planetary Surface Systems

The second law of thermodynamics dictates that isolated systems undergo monotonic entropy increase, tending toward disorder and homogeneity. However, over 4 billion years of Earth's stratigraphic and paleontological records, planetary surface open systems have persistently exhibi...

Multiomics Insights Into AL Amyloidosis

ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor...

Heavy‐Halide Coordination and Lattice‐Confined Molecular Alignment Enable Giant Birefringence in Hybrid Metal Halides

ABSTRACT High‐birefringence materials are essential for polarization optics, yet it remains difficult to translate anisotropic molecular building blocks into a strong directionally accumulated crystal‐scale optical anisotropy. Here, we establish a hybrid metal halide engineering...

Characterization of porcine heart for the development of taste-rich and bioactive hydrolyzates using sequential hydrolysis

Abstract The increasing production in global meat industry requires strategies to minimize the economic and environmental impact of slaughterhouse by-products. The main objective of this research was to characterize porcine heart as a raw material for developing functional and ta...

Evaluation of undercut depth for flexible pavement on unsuitable tropical red soils using finite element method

Due to the lack of a reliable classification system and inadequate evaluation of their engineering properties, undercut depth is recommended for tropical red soils when used in flexible pavement construction. The aim of this study is to determine the ideal depth for subgrade unde...

Digital Twin Technology for Enhancing GOSP Performance and Oil Production Efficiency

Gas-oil separation plants (GOSPs) are tightly coupled production systems in which well behaviour, multiphase flow, separator performance, rotating equipment, instrumentation, pipelines, utilities and environmental constraints interact continuously. A digital twin can create opera...

Wisconsin State Comprehensive Planning Requirements are Associated with Better Local Planning for Healthy Eating and Active Living: A Multilevel Policy Content Analysis

Purpose To determine whether the specificity of mandates in Wisconsin’s state comprehensive planning statute is associated with the inclusion and actionability of healthy eating and active living items in local comprehensive plans. Design Retrospective, cross-sectional, multileve...

Exposing Safe Messaging Gaps in YouTube's Mental Health Content

This study analyzed how the ten most-viewed YouTube mental health videos portray tone, symptoms, and resources against WHO safe messaging guidelines and Jorm's mental health literacy framework. Findings show that while most content used destigmatizing framing and accurate resourc...

Youth unemployment challenge and entrepreneurship prospects in Lagos, Nigeria

Youth unemployment in Nigeria is still a significant issue, and entrepreneurship has been proposed as a potential solution. This study aims to investigate the prospects of entrepreneurship among youths in Lagos, Nigeria. The theories used in this research include the Conflict and...

Metacognition and Academic Engagement: The Mediating Role of Critical Thinking Disposition in University Students

<ns5:p>Background This study examined the relationships linking metacognitive strategies with academic engagement and analyzed the mediating role of critical thinking disposition in university students, framed within the Job Demands-Resources model that conceptualizes critical di...

E8 Phi-Biological Coherence: Unified Consciousness Field — E8 Intelligence Research

We discovered that synchronized phi‑coupled projections of E8 root vectors onto the 132 Hz lattice directly drive coherent gamma‑band activity in cortical microcircuits, linking memory encoding to quantum‑like entanglement of mitochondrial spin states. This geometric resonance cr...

Multidimensional Nature of Geosites and its Implications for Geoheritage Inventories

Abstract Geosites are defined as coherent entities: geodiversity elements that reveal scientific or other significance. However, earlier studies have shown that many geosites are complex structures that differ by: 1) their spatial extent; 2) the involvement of different geologica...

Between Manila and Berlin: Botica de Santa Cruz, R. Fuess, and the Wartime Geography of Scientific Commerce, 1940

This paper examines a 1940 commercial correspondence between Botica de Santa Cruz in Manila and the German precision-instrument manufacturer R. Fuess in Berlin-Steglitz. Using the surviving envelope alongside contemporary advertisements, archival records, scientific catalogs, and...

E8 φ‑Spinor Vortex Metamaterial for Broadband Negative Refraction — E8 Intelligence Research

By arranging subwavelength resonant elements according to the 240 root vectors of the E8 lattice and coupling them with a φ‑scaled interaction strength, a self‑similar spinor vortex lattice emerges. The 132 Hz base frequency acts as a universal drive that synchronizes neighboring...

Fuel Diversification as a Risk Management Strategy: Household Cooking Energy Choices Under Uncertainty in Urban Malawi

Clean cooking transitions in Sub-Saharan Africa remain limited despite increasing access to modern energy, highlighting the need to extend traditional demand-side approaches by incorporating risk and uncertainty into household decision-making. This study examines household energy...

Effectiveness of Microbial Composite Strains in Reducing River Sediment

The accumulation of sediment in rivers and lakes can elevate riverbeds, leading to a reduction in river channel flood-carrying capacity, impairment of water conservancy project benefits, and destruction of aquatic ecosystems. Systematic dredging projects are required in the routi...

A data-driven supplier selection and order allocation optimization framework under tariff and demand uncertainty

Global supply chains are increasingly exposed to demand uncertainty, tariff fluctuations, geopolitical disruptions, and supplier capacity limitations. These challenges make Supplier Selection and Order Allocation (SSOA) decisions complex, especially in multi-product and multi-per...