Research works

Age-Driven Cardiovascular Risk Scores Differ Across Antiretroviral Regimens Among People Living with HIV in the Colombian Caribbean Region

Background/Objectives: People living with HIV (PLHIV) face an elevated burden of cardiovascular disease, and general-population and HIV-specific risk scores are commonly used for stratification, though data from Latin America, particularly Colombia’s Caribbean region, remain scar...

The TET Protein Family in Gliomas: Epigenetic Regulation, Molecular Pathogenesis, and Therapeutic Opportunities

Epigenetic dysregulation is a defining feature of glioma pathogenesis, with aberrant DNA methylation contributing to tumor initiation, cellular plasticity, progression, and therapeutic resistance. The ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, and TET3) ca...

Escherichia coli ST131 isolates are rare in human meningitis but belong to a distinct O25b-fimH22 clade B lineage shared with avian pathogenic Escherichia coli

Escherichia coli ST131 is a globally disseminated extraintestinal lineage best known for its resistance-driven expansion, yet it is rarely reported as a cause of neonatal meningitis. Whether specific ST131 sublineages retain neuroinvasive potential remains poorly understood. We a...

Governing the Privacy-Personalization Tension in AI-Driven Marketing Platforms: An Integrative Framework for Customer Data Platforms

Customer data platforms (CDPs) are increasingly positioned as the data and decision infrastructure of artificial intelligence (AI)-driven marketing. Yet the academic literature has not adequately explained when a CDP can reconcile privacy compliance with hyper-personalization, no...

Pedal acceleration time—Guided management of diabetic foot ulcers with borderline ischemia

Background: The management of diabetic foot ulcers (DFUs) with borderline ischemia remains challenging due to the absence of reliable physiological markers to guide revascularization decisions. Pedal acceleration time (PAT) is a Doppler-derived measure of distal perfusion that ma...

Mechanical Recovery of Damaged Glass Fiber Reinforced Polypropylene via Repetitive Sub-Melting Thermal Annealing: A Molecular and Structural Study

This study clarifies the mechanical recovery and structural retention of damaged glass fiber-reinforced polypropylene (PP/GF) composites subjected to repetitive sub-melting thermal annealing at 160 °C. Initial thermal annealing increased matrix crystallinity from 0.30 to 0.37 (+2...

Dual Fluorophore System for Direct Measurement of Acidity of Aerosol Particles

Abstract Atmospheric aerosol particles exhibit diverse physical and chemical properties, depending on their composition and source, which are challenging to measure directly due to their chemical complexity. Aerosol acidity is a key chemical property that has significant implicat...

Scenario-Based Dynamic Assessment of Rooftop Solar Photovoltaic and Heat Pump Systems for Low-Emission French Single-Family Houses

Achieving the European Union’s (EU) climate neutrality targets requires residential buildings to reduce operational carbon emissions, while increasing on-site renewable generation. However, the relative contributions of rooftop photovoltaic (PV) systems with battery storage and h...

Beyond monospecificity in systemic lupus erythematosus: Emerging roles of bispecific and trispecific antibodies

Purpose Targeted biologic therapy has changed the management of systemic lupus erythematosus (SLE), including lupus nephritis (LN), but incomplete response, relapse, glucocorticoid dependence, and refractory organ disease remain common. This article discusses whether bispecific a...

Parkinsonism with Reduced Striatal Uptake on DAT-SPECT in a Patient Harboring a Novel KCND3 Variant

KCND3 encodes the voltage-gated potassium channel Kv4.3, and pathogenic variants in KCND3 are associated with spinocerebellar ataxia type 19/22 (SCA19/22) and related neurological phenotypes. Here, we report a Japanese patient harboring a novel KCND3 missense variant, classified...

Opting out of Voter Registration: An Analysis of Statewide Automatic Voter Registration Policies in the United States (2012-2024)

Analyzing CES and CPS survey data from 2012 to 2024, I evaluate whether the adoption of an opt-out AVR policy increases registration and turnout across the electorate, as well as among groups specifically targeted by these policies - movers and young people. Difference in differe...

Attributing PM2.5 and NO2 Changes One Year after New York City’s Congestion Pricing Policy

Abstract In January 2025, New York City implemented the Central Business District Tolling Program (CBDTP), a congestion pricing policy targeting lower Manhattan. We evaluate its first-year air quality effects using ground-based and satellite observations. Comparing New York City...

Bioactive Chitosan Membranes Loaded with Nile Tilapia Skin Peptides Promote Wound Healing Associated with Temporal Inflammatory Modulation

Abstract Bioactive wound dressings that combine structural support with local biological activity are promising for skin repair. Nile tilapia skin peptides (NTSP) have demonstrated wound-healing potential, while chitosan (CS) offers favorable film-forming, biodegradable, and woun...

CyberRoBERTa: A Lightweight Transformer-Based Language Model for IoT Intrusion Detection

With the accelerated proliferation of the Internet of Things (IoT) and its widespread use in sensitive areas such as healthcare, homes, and factories, security has become an increasingly critical concern. IoT remains one of the most challenging domains to secure, lacking the mana...

Light stimuli attenuates inflammatory activation in primary bone marrow-derived macrophages

Abstract Bone repair depends on a regulated macrophage-driven inflammatory response. Non-activated macrophages (M0) differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in response to microenvironmental signals. This study evaluated, in vitro, the effects...

An inventory, threat and conservation assessment of UK wheat landrace diversity

Abstract In the early 20th century, agricultural production was mostly focused on traditional, low-input systems where seed was actively selected by farmers and then frequently saved on-farm for sowing in subsequent seasons. More recently, the replacement of diverse landraces (LR...

Intratumoral desmoplastic stroma in carcinoma brain metastases harbors stromal cells with a cancer-associated fibroblast (CAF)-like immunophenotype

Abstract Background Research on the tumor microenvironment of brain metastases (BM) has largely focused on immune response, while the intratumoral stromal compartment remains poorly characterized. In primary carcinomas, cancer-associated fibroblast (CAF) are intratumoral stromal...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Comparing the bioactivity of grape byproducts (pomace, seed extract, and skin/pulp food coloring) on DSS-induced intestinal stress in early life

According to the 2024 Progress Report for Sustainable Development Goal (SDG) Target 12.3, the call to halve global food waste is rapidly growing out of reach, and immediate action, no matter the perceived scope, is urgently needed. A major opportunity lies in grape pomace (GP)—th...

Random fitness landscapes are highly navigable

Abstract With the increasing availability of large-scale empirical fitness landscape data, there is a need for simple yet informative null models that can be used to interpret metrics of landscape ruggedness and navigability. A natural choice of a null model for highly rugged lan...