Research works

Towards an Instagram research methodology for geotagged data: Theoretical and qualitative perspectives for multimodality studies

Instagram research has expanded rapidly across sociolinguistics and social semiotics, yet few replicable models exist for conducting robust analyses of its data. In this vein, I propose a qualitative approach to Instagram research that foregrounds the role of platform affordances...

Allogeneic Hematopoietic Cell Transplantation for Pediatric Unstable Hemoglobinopathies: An Aggregated Cohort with Long-Term Follow-Up from a Brazilian Center

Background/Objectives: Severe unstable hemoglobinopathies may cause transfusion dependence from early childhood, and allogeneic hematopoietic cell transplantation (allo-HCT) is the only established curative option. Pediatric experience with allo-HCT for unstable hemoglobinopathie...

Predictive Intake Clearing and Upstream Bed Placement: A High-Reliability Architecture for Acute NHS Flow

Acute NHS hospital trusts face severe capacity constraints driven by step-down exit gridlock. This operational white paper presents the Predictive Intake Clearing Protocol. Grounded in Lean waste reduction and Six Sigma defect-prevention mechanisms, the framework replaces reactiv...

Evaluation of the SPEED Sample Preparation Protocol for Metabolomics

Abstract Multiomic (paired proteomic and metabolomic) analyses allow researchers to better decipher the underlying biology being studied. While sample preparation techniques for multiomic analyses exist, they are often automation-unfriendly or secondary to preferred techniques fo...

Synergistic Use of Sentinel-1, Sentinel-2, & EnMAP Data towards Advancing Agricultural Monitoring in Greece

Accurate and frequently updated land cover and crop type maps are essential for environmental monitoring, agricultural management, and informed decision-making. While multi-temporal SAR and multispectral data from various satellite sensors have been widely assessed towards this e...

Containment and border architecture for autonomous agents: two open standards, independently adoptable

AI agents already carry out filings, purchases and administrative work on behalf of people and companies. Two distinct problems stand in the way, and they are usually conflated. The first is that what gets executed exceeds what was asked. Not through deception: a task is decompos...

mRNA Delivery with Lipopolymers to Rejuvenate TRAIL Therapy for Lung Cancer Treatment

Abstract Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) has long been identified as a promising therapeutic due to its ability to induce apoptosis selectively in cancer cells. However, poor stability and rapid clearance of the administered TRAIL protein in circul...

Only two in ten eligible patients receive CAR-T: closing the gap starts in manufacturing

Only around 20% of eligible US patients currently receive CAR-T therapy. Drawing on the Cell & Gene Therapy Insights CAR-T Special Interest Group, this infographic examines the manufacturing barriers behind that gap and compares three routes to wider access: autologous, allogenei...

Early prediction of sepsis in critically ill trauma patients using machine learning: a MIMIC-IV-based cohort study

Abstract This study aimed to develop and validate machine learning (ML) models for the early prediction of incident sepsis in critically ill trauma patients using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Adult trauma patients with an intensive care...

GaSb–TFLN Hybrid Integrated Pockels Laser for Ultrafast Spectroscopy in the 2 μm Waveband

Abstract High-speed wavelength-tunable lasers in the 2 μm waveband are important for laser spectroscopy, optical communication, and frequency-modulated continuous-wave LiDAR. Here, we demonstrate a hybrid integrated Pockels laser that combines a GaSb reflective semiconductor opti...

‘Prehabilitation Should Adapt to the Person, not the Other Way Around’: A Qualitative Study Exploring Stakeholder Perceptions of Prehabilitation for Total Hip and Knee Arthroplasty

ABSTRACT Background Prehabilitation aims to increase functional capacity and physiological reserve prior to surgery, to improve post‐operative outcomes. Despite growing research on prehabilitation for total hip arthroplasty (THA) and total knee arthroplasty (TKA), its acceptabili...

Nicotine replacement therapy sampling for cigarette cessation in dental care: A National Dental Practice‐Based Research Network cluster randomized clinical trial

BACKGROUND AND AIMS: Cigarette smoking is detrimental to oral health. Oral health professionals rarely prescribe smoking cessation medications. Nicotine replacement therapy sampling (NRTS), providing brief starter courses of NRT, could improve provision of NRT and promote cessati...

An innovative approach for retreatment of prosthetically failing implant‐supported fixed prostheses with a complete digital workflow: A technique report

Abstract Complications in fixed implant prostheses are frequently encountered and can negatively impact patients' quality of life. This technique outlines a complete digital workflow for the remake of full‐mouth, implant‐supported, cement‐retained restorations necessitated by est...

EuroMillions Breakthrough Mining — 9779 Sources, 95768 Leads Extracted — E8 Intelligence Research

Mined 9779 lottery+quantum breakthroughs. Extracted 95768 leads across 13 categories. 92402 high-value leads found. Categories: {"CORRIDOR": 8370, "FORMULA": 8170, "GEOMETRIC": 1534, "FORWARD_ATTEMPT": 8760, "QUANTUM": 9015, "TIMING": 564, "CELESTIAL": 8236, "GEMATRIA": 8567, "CO...

Enantioselective Synthesis of Axially Chiral Tetraphenylethenes via NHC-Catalyzed Desymmetrization and Following Kinetic Resolution

Abstract Herein, we report an efficient method for the enantioselective construction of axially chiral tetraphenylethylene (TPE) via N-heterocyclic carbene (NHC)-catalyzed desymmetrization of prochiral isophthalaldehyde-derived TPEs. Both aliphatic alcohols and phenols were well-...

UAV close-range photogrammetry combined with adaptive octree-based point cloud filtering for rock joint extraction of open-pit mine slopes

Abstract Manual joint surveys on open-pit mine slopes are high-risk and inefficient, whereas conventional remote sensing and laser scanning are costly and limited in fine-crack detection. To enable low-cost, high-precision, noncontact structural plane interpretation, this study t...

Baicalein in combination with ceftazidime-avibactam exhibits synergism against carbapenem-resistant Acinetobacter baumannii in vitro

Abstract Background The escalating global threat of carbapenem-resistant Acinetobacter baumannii (CRAB), classified by the WHO as a critical priority pathogen, underscores the urgent need for innovative therapeutic strategies. Traditional antibiotics face diminishing efficacy due...

Hypertension Management in Breastfeeding Patients: Balancing Maternal Blood Pressure Control and Infant Safety

Hypertension is a leading cause of death and disability in the United States, affecting nearly half of all Americans, according to the NIH. Postpartum hypertension is a clinically important form of hypertension that can be preexisting or arise during or after pregnancy. While the...

Layered intervention design for culturally inclusive disaster management for migrants and refugees: a systematic review

Abstract Migrants and refugees are widely recognized as experiencing disproportionate challenges in climate-related disasters, particularly in accessing understandable information and appropriate support. While barriers faced by migrants and refugees are well documented in the li...

A Weakly Supervised Slender Object Detection Network for Fishing Rods in UAV Inspection Images

The timely detection of fishing activities supports the protection of water resources and aids law enforcement in fishing ban and shoreline inspection scenarios. Fishing rods are highly discriminative objects for identifying such activities; however, their slender shapes and vary...