Research works

Associations Between Physical Activity Measurement Modality and Gut Microbiome in Breast Cancer Survivors

Background/Objectives: Physical activity (PA), physiological fitness, and the gut microbiome have each been linked to health outcomes among breast cancer survivors (BCS); however, these associations have been inconsistent. Few studies have directly compared the associations of se...

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells

Abstract Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. Following antigen recognition, IL2 receptor (IL2R) signaling polarizes towards the immunological synapse (IS). However, how IL2 function is integrated du...

Spin-Vibronic Mechanism of Light-Driven Coordination-Induced Spin-State Switching in a Nickel(II) Complex

Abstract In Ni(II) complexes, spin-state switching is governed by changes in the coordination number and the nature of the ligand field. We report the ultrafast photorelaxation of an axial-pyridine-coordinated octahedral Ni(II) complex with a phenazine fluorophore using multi-con...

Melatonin loaded phytosomes for enhanced therapy against ethanol-induced gastric ulcer: Formulation, optimization and in vitro / in vivo evaluation

Healing of gastric ulcer (GU) can terminate the progression into more serious deteriorations. A promising and versatile vesicular nanoformulation, namely; phytosomes (PHY), was fabricated to maximize the GU healing efficacy of the naturally occurring bioactive component; melatoni...

Quantifying Free-Roaming Horse Body Condition: A Methodological Investigation Using Game Cameras and Observer Bias Corrections

Large populations of free-roaming horses (Equus caballus ) inhabit the western United States, Australia, and other arid and semi-arid rangelands globally. In the United States, horse body condition has been the impetus for gathering and removing horses under an emergency designat...

Artificial Intelligence and democracy: A Delphi Study Into Opportunities and Threats

As Artificial Intelligence (AI) penetrates all sectors of society, academic attention to its relationship with democracy is rapidly increasing, leading to a growing body of literature. Optimists expect AI to strengthen democracy, while pessimists argue that it may undermine its e...

Sensory receptor expansion and neural accommodation in butterfly color vision

The evolution of complex brains required the incorporation of newly evolved neurons into existing circuits, yet the genetic and developmental mechanisms enabling their integration remain poorly understood. Butterflies expanded their color vision by adding a second R7 photorecepto...

CFTR Functional Rescue and Heterogeneous Clinical Outcomes Following Elexacaftor/Tezacaftor/Ivacaftor Therapy in People with Cystic Fibrosis Carrying the W1282R Variant

The clinical response to elexacaftor/tezacaftor/ivacaftor (ETI) in people with cystic fibrosis carrying the rare cystic fibrosis transmembrane conductance regulator (CFTR) variant W1282R has not been well characterized. We retrospectively analyzed 12 people with cystic fibrosis t...

Effects of approved anti-obesity medications on depression symptoms, psychiatric adverse events, and quality of life in adults who are overweight or obesity: a systematic review and Bayesian network meta-analysis

Pharmacological weight management has expanded rapidly with the introduction of GLP-1 receptor agonists and dual GIP/GLP-1 agonists, yet their comparative effects on mental health remain unclear. We systematically searched PubMed, Embase, Cochrane CENTRAL, PsycINFO, and ClinicalT...

Prevalence and associated risk factors of anal high-risk human papillomavirus infection in unvaccinated young men who have sex with men visiting the Center of Sexual Health of Amsterdam

Background: Anal high-risk human papillomavirus (hrHPV) is highly prevalent among men who have sex with men (MSM) and the main cause of anal cancer. The effectiveness of HPV vaccination in this population is highly dependent on prior HPV exposure. We aimed to assess the prevalenc...

Ergot severity, ergot incidence and quality characteristics in German winter rye hybrid and population varieties

Ergot, caused by the fungus Claviceps purpurea , is a major disease in rye, leading to yield loss and contamination with ergot alkaloids that pose food safety risks. Against the background that the EU has significantly tightened the acceptable limits for ergot sclerotia since 1 J...

Artificial intelligence in male infertility from diagnosis to treatment

Male factors account for almost half of all infertility cases and afflict approximately 186 million men globally, presenting a substantial and increasing public health burden. Semen analysis is the standard of care for assessing male fertility, but subjective visual interpretatio...

Frontline perceptions of middle management as a bottleneck in cybersecurity escalation and risk communication

Purpose This study examines how frontline cybersecurity professionals perceive middle management's role in the escalation and communication of cyber risk within large organizations, and identifies the communication failures they associate with delayed or incomplete reporting of c...

Fasting-induced headache in Ramadan: a scoping review with implications for clinical practice

Introduction Headache attributed to fasting is a recognized secondary headache in the International Classification of Headache Disorders, 3rd edition (ICHD-3), defined as a diffuse, non-pulsating headache developing during fasting and relieved after eating. It is especially relev...

International organizations’ role in domestic public sector digitalization: a proposal for a typology examining directions and instruments of influence

This article examines how international organizations (IOs) contribute to orienting public sector digitalization by analyzing the directions and instruments through which they influence domestic reforms. Building on the literature on policy rationales, it develops a multidimensio...

Trend analysis of breast cancer screening in Golestan province’s family physician program: performance evaluation for women aged 30–69

In the ranking of cancer incidence for the year, female breast cancer was the most common cancer in the north-east region of Iran. This study aimed to comprehensively evaluate the trend of breast cancer screening within Golestan province’s Family Physician Program. This repeated...

Impact of Fluorine Content on Structure, Redox, and Electrochemical Performance of Disordered Rock-Salt Li1.25Mn0.5+ y /2Nb0.25– y /2O2– y F y Electrode Materials

Abstract Disordered rocksalt (DRS) oxides are highly promising positive electrode materials for next-generation Li-ion batteries, yet their practical application is severely bottlenecked by the irreversibility of oxygen-redox processes. Fluorination (O2– by F– substitution) repre...

The microstructure and some properties of the novel biomedical ZrTiFe alloy subjected to high-pressure torsion deformation

Abstract Zr- and Ti-based alloys, due to their excellent mechanical, physical, and biological properties, are increasingly used as biomaterials. Although these alloys have been used in medical applications for over 60 years, several issues remain associated with their use in this...

Oxidative Stress Burden in Paediatric Sickle Cell Anaemia: Effects of Hydroxyurea Therapy, Disease Severity, and Socioeconomic Factors

Background: Oxidative stress plays a central role in the pathophysiology of sickle cell anaemia (SCA), contributing to haemolysis, endothelial dysfunction, and disease complications.Hydroxyurea (HU), the main disease-modifying therapy for SCA, may influence oxidative balance; how...