Research works

Human trilayer engineered blood vessel reveals influence of fibroblasts on disease progression in model of Hutchinson-Gilford progeria

In vitro models of vascular disease have focused primarily on the pathophysiology of smooth muscle cell (SMC) or endothelial cell (EC). Adventitial fibroblasts can contribute to disease progression, but their specific influence is not well understood in different disease contexts...

Bridging skills gaps: how micro-credentials reshape sustainable development learning in higher education

Abstract Micro-credentials (MCs) are gaining traction in higher education as essential tools for advancing sustainable development (SD). These short, focused courses provide learners with specific skills and knowledge related to sustainability, enabling them to address pressing g...

Explainable Stability Certification of Reinforcement Learning Control Policies Using Sparse Dynamics Identification

Reinforcement learning (RL) is a promising alternative to classical guidance and control methods; however, the black-box nature of deep neural network policies and the lack of interpretable stability evidence remain barriers to real-world aerospace adoption. This paper presents a...

Changes in students’ self-perceived interprofessional collaborative skills following participation in the student health service program

Interprofessional collaboration is recognized as a key component of effective healthcare systems. In France, the Student Health Service (SHS) is the only mandatory and universal interprofessional training experience in health curricula. However, evidence regarding its impact on i...

Impact of High-Density Urban Environment on Residents’ Heat Risk: Evidence from Shenzhen, China

This study explores the nonlinear effects of urban environmental factors on heat risk in Shenzhen, a typical high-density megacity. We established a multidimensional indicator system covering the built environment (building density, road density), ecological conditions (Enhanced...

Comparative analysis of outcomes of surface ablation for myopic astigmatism in patients after PKP and DALK

Purpose To compare the outcomes of surface ablation (SA) in patients who have previously undergone Deep Anterior Lamellar Keratoplasty (DALK) and Penetrating keratoplasty (PKP). Methods This retrospective study evaluated the outcomes of SA in Keratoconus (KCN) patients who had pr...

Lessons Learned: Reflections on EJScreen’s History and Future

Based upon his over ten years of experience leading the deployment and evolution of the U.S. EPA’s EJScreen, a former EPA official shares some of the most important lessons learned regarding the creation, growth, and use of such tools. These lessons are shared both to document th...

Knowledge, attitudes, and practices toward dolutegravir-based antiretroviral therapy among people living with HIV receiving ART at Bule Hora University steaching hospital, Ethiopia: a cross-sectional study

Abstract Background Dolutegravir (DTG)-based antiretroviral therapy (ART) is the World Health Organization (WHO)-recommended first-line regimen because of its high efficacy, favourable safety profile, and high genetic barrier to resistance. Although Ethiopia has adopted DTG-based...

Planetary Health in Nursing Scholarship: A Bibliometric Mapping of Climate Change, Sustainability, and Health‐System Transformation

ABSTRACT Background Planetary health is an increasingly important transdisciplinary approach in nursing because it links human health and equity to the integrity of Earth's natural systems. Climate change is a major component of planetary health, but it is not synonymous with the...

Intratumoral Immunotherapy—The Future of Treating Merkel Cell Carcinoma?

Merkel cell carcinoma (MCC) represents a rare but highly aggressive neuroendocrine skin cancer with limited systemic therapy options for patients who fail or are ineligible for immune checkpoint inhibitors (ICIs). Intratumoral (IT) immunotherapy has emerged as a promising strateg...

Circadian dysregulation of leptin and its role in skin inflammation and obesity: an integrative perspective

Abstract Purpose Leptin is an adipokine that regulates energy balance and is commonly linked to obesity. It exhibits a circadian rhythm that can be disrupted by variations in eating times and sleep disorders. This brief review explored how leptin can modulate appetite and tissue...

Fear of missing out and neck disability: The indirect association through postural attention in social media users

Background Despite widespread digital device use, the relationships of Fear of Missing Out (FoMO) with postural awareness and neck disability remain poorly understood. Objective This study examined the associations among FoMO, postural awareness, and neck disability, testing whet...

Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study

Intraoperative lung protective ventilation and, in inhalational anesthesia, minimal fresh gas flow (FGF) are recommended. It remains unclear how these recommendations are transferred to clinical routine. We aimed to assess corresponding anesthesia practices in Germany and raise a...

Continuous-Flow Synthesis of the Key Nicergoline Intermediate 10α-Methoxy-9,10-dihydrolyserol via Photomethoxylation

Abstract At present, the key nicergoline intermediate 10α-methoxy-9,10-dihydrolyserol (3) is predominantly synthesized by photomethoxylation in batch photoreactors, a conventional method plagued by issues such as poor light penetration, low energy efficiency, severe scale-up barr...

Autoethnography for Learning in Sports Coaching

Autoethnography involves autobiography and ethnography as a personalized account of lived experiences to explore social phenomena. It has been used in several subject areas, relies on reflective practice, and can promote the development of critical thinking. In this study, we sho...

Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening

Abstract The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection aga...

Critical Membrane Concentration and Baseline Toxicity of Organic Pollutants in a High-Throughput Rainbow Trout Cell Assay

Abstract A high-throughput RTgill-W1 cytotoxicity assay (RTgillHT) was developed using 384-well plates and live/dead staining combined with high-content imaging to quantify cytotoxicity. RTgillHT facilitated a significant increase in sample throughput compared to the OECD Test Gu...

Mastodon: the command center for large-scale lineage-tracing microscopy datasets

Understanding development in living organisms requires following the divisions, movements, and fates of cells. While advances in microscopy have enabled whole-embryo imaging at the cellular level, extracting and analyzing cell lineages from these massive datasets remains a signif...

Technical Review: Performance, Design, and Deployment of Steel Helical Pile Groups for Transmission Infrastructure

Worldwide transmission-grid expansion requires extensive construction of new tower foundations across diverse geological, environmental, and logistical conditions, while conventional bored piling faces increasing cost, schedule, constructability, and adaptability constraints. Ste...

Tobacco use and increased risk of ACL and meniscus injury and surgical intervention: a matched-cohort study of 3 million patients

Abstract Meniscus and anterior cruciate ligament (ACL) tears are among the most common knee injuries, yet little is known about whether tobacco use affects their incidence, need for subsequent surgery, or postoperative hospital length of stay (LOS). We retrospectively analyzed a...