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The 2nd Next Generation Conversation: Albany @ Ruston

Abstract This commentary is a report on the 2nd Next Gen. Conversation: Albany @ Ruston 2026 (the 22nd Albany Conversation) held on the campus of Louisiana Tech University June 9–13, 2026. The 3rd Next Gen. Conversation will be held at Louisiana Tech University June 13–17, 2028....

Five Questions for the Next Thirty Years of Federal Sentencing

This essay reflects on the first three decades of the federal sentencing guidelines system and identifies five foundational questions that should guide future sentencing reform. Using the Pennsylvania Sentencing Guidelines as a comparative model, the essay evaluates whether the c...

GUARDAID: an open standard for agent identity and mandate verification

Today a person signs a permission, not a list of acts. A service receiving an agent has no way to know who answers if something goes wrong, so it blocks — legitimate agents included. GUARDAID defines the format and the procedure by which a person signs, with a key that never leav...

Restitution and the Production of Legal Doctrine

This Article examines the relationship between legal doctrine and remedial law through the lens of restitution, arguing that differences between American and English restitution jurisprudence stem less from divergent substantive rules than from competing assumptions about the rol...

Antcar: Simple Route Following Task with Ants-Inspired Vision and Neural Model

The goal of this project is to develop a new method of Route following for mobile robots in a GNSSdenied environment like urban canyons or indoor. We used a robust biologically constrained neural model inspired by ants developed previously in simulation to assess the familiarity...

Mergers Fall Short: Nonmerger Channels Required for Galactic Heavy Element Production

Abstract Since the discovery of the binary neutron star merger GW170817 and its associated kilonova, neutron star mergers have been established as a key production channel for r -process elements in the Universe. However, multiple lines of evidence, including the observations of...

See-through leaf: front/back alignment of the Voynich herbal leaves (88 pairs) and a preregistered blind test of the "root traced through the parchment" hypothesis - with results

Registered-report style deposit. (1) Data and code of the page voynich.site/see-through-leaf (published 7 October 2026): the mirrored back of each regular leaf of the Voynich manuscript (Beinecke MS 408) aligned to its front by the parchment edges on the Yale scans - an alignment...

The genetic basis for the production of toxic quinolizidine alkaloids in lupins

Lupins ( Lupinus spp.) are promising protein crops that accumulate bitter and toxic quinolizidine alkaloids (QAs). The effective removal of QAs through new breeding technologies is hampered by a poor understanding of their biosynthesis. In this study, we used pathway reconstructi...

Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs

The extraordinary lifespan variation in domestic dogs provides a natural experiment for testing how intrinsic rates of biological aging shape lifespan. Using 1640 methylomes from 894 dogs, we developed an epigenetic clock that predicted mortality and demonstrated that epigenetic...

Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Abstract Artificial intelligence (AI) methods for proteins have advanced rapidly, improving structure prediction and design, particularly for de novo binders. However, most evaluations emphasize binding affinity rather than higher-order biological function. We present Bits to Bin...

FDCL Part XI: Dynamical SU(2) Gauge Fields on FDCL Graphs — Hierarchical Curvature Completion and Local Spectral Bounds

We specify a dynamical SU(2) gauge model on finite FDCL voxel graphs, with Gauss invariance at every vertex. Unit plaquettes miss a central flux whose shortest detecting loop has length 2n + 4. An explicit hierarchical catalogue completes nonabelian flatness with the minimum numb...

Conviction Is Not Commission: A Methodological, Conceptual, and Ethical Critique of Khoshnood et al.

Khoshnood et al. (2026) report a strong association between immigrant background and rape convictions in Sweden using nationwide register data and a matched case-control design. This commentary argues that the study suggests important descriptive evidence on conviction patterns,...

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse over nearly two weeks of development. From one embryo, we reconstruct a time-calibr...

Unsettling the case study in gentrification research: Leveraging data science for new geographies of urban theory

Case studies have long been the dominant methodological approach in critical urban theory. But reliance on case studies limits the ability to do systematically comparative research. One alternative is a turn toward data science in critical urban research. Such emerging methods ca...

MR Cytometry of Microstructural Changes in Breast Cancer: Association With Treatment Response and Prognosis

ABSTRACT Background Although MR cytometry can probe microstructural features, the longitudinal trajectories of these changes during neoadjuvant chemotherapy (NAC) and their association with treatment response and prognosis remain poorly defined. Purpose To characterize longitudin...

Insights from more than a year of ongoing episodic lava fountaining at Kīlauea

Episodic lava fountaining is rare globally, with only three occurrences from Kīlauea (Hawaii) since 1823. Beginning in December 2024, an eruption within the summit crater, Halemaʻumaʻu, has produced 54 fountaining episodes to date, each lasting typically for hours and separated b...

A fast radio burst at redshift 2, three billion years after the Big Bang

Fast radio bursts (FRBs) are millisecond-duration radio transients from extragalactic sources. Their frequency and polarization properties are affected by plasma and magnetic fields along the line of sight to Earth. We report radio observations of FRB 20240304B and near-infrared...

FDCL Part XII: Haar-Preserving Assembly in FDCL SU(2) Gauge Models — State Preparation, Shared-Link Responses, and Delayed Transfer

We study which information block assembly must retain to preserve responses in finite-graph SU(2) gauge theory. Scalar, pairwise and oriented triple invariants classify simultaneous conjugation orbits; we give exact consistency conditions including singular Gram ranks. Vertex mul...

Photoredox/Cobalt-Catalyzed Cascade Rearrangement-Cyclization of Alkene

A photoredox/cobalt-catalyzed sequential rearrangement-cyclization of unactivated alkenes is reported. 1,1diarylalkenes bearing tethered nucleophiles undergo a selective 1,2-aryl migration, initiated by metal-hydride hydrogen atom transfer and radical-polar crossover, and followe...

SWOT‐Fitted River Bathymetry for Global Hydrodynamic Models

Abstract We present a robust, global method to reconcile absolute water surface elevations (WSE) from the Surface Water and Ocean Topography (SWOT) mission with a large‐scale hydrodynamic model by iteratively correcting river bathymetry. After removing sensor and representativene...