Research works

Histopathological Patterns in Drug-Induced Liver Injury

Histopathological Patterns in Drug-Induced Liver Injury: Analysis of 63 CasesABSTRACTObjective: This study aimed to evaluate the histopathological findings and injury patterns in liver biopsies from patients with suspected drug-induced liver injury (DILI).Materials and Methods: S...

Fin whale movement patterns from the Mediterranean sea reveal summer habitat use in the North Atlantic and potential feeding behavior

Abstract Understanding the movements of highly mobile marine species is essential for identifying critical habitats and developing effective conservation measures. Although occasional movements of fin whales ( Balaenoptera physalus ) between the Mediterranean Sea and the North At...

Task-oriented RT-DETR adaptation for minute cigarette detection in complex laboratory scenes

Abstract Detecting minute cigarettes in complex laboratory surveillance scenes is challenging because of their small scale, partial occlusion, weak visual cues, cluttered backgrounds, and sensitivity to bounding-box deviations. This study develops a task-oriented adaptation of th...

A Spectral Projected Gradient Algorithm for an Elliptic Inverse Coefficient Problem with a Robin Boundary Condition

An inverse problem of recovering a lower-order coefficient in a second-order elliptic equation with a Robin boundary condition is considered. Uniqueness of the inverse problem solution is established. For the numerical solution of the inverse problem, a difference scheme is const...

Topical Corticosteroids in the Treatment of Phimosis in Children

Phimosis, the inability to retract the prepuce over the glans penis, is one of the most common reasons for referral of boys to pediatric surgeons and urologists, yet the great majority of cases represent a normal developmental stage rather than true disease. Distinguishing physio...

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Abstract Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain...

Spin Polarization Enables Spin-Conserved Intermediate Migration for Selective C–N Coupling toward Urea Electrosynthesis

Abstract Electrochemical coreduction of CO2 and nitrate to urea offers a promising approach to carbon–nitrogen fixation but still suffers from sluggish C–N coupling and severe competition from ammonia formation. Existing studies primarily focus on intermediate adsorption and larg...

Applying 177Lu-Dotatate for Hereditary Neuroendocrine Tumours: The Role in MEN1

Abstract Introduction Multiple endocrine neoplasia type 1 (MEN1) is the most common genetic syndrome causing neuroendocrine tumours (NET) with metastatic duodenopancreatic NET (dpNET) forming the predominant cause of MEN1-related mortality. Peptide receptor radionuclide therapy w...

Comparison of two repetitive peripheral magnetic stimulation protocols for upper trapezius myofascial pain syndrome: A randomized trial

Background Upper trapezius myofascial pain syndrome (MPS) is a common contributor to chronic neck pain and functional limitations. Repetitive peripheral magnetic stimulation (rPMS) has emerged as a non-invasive neuromodulatory intervention; however, the optimal stimulation durati...

Effectiveness of Community-Based Educational Interventions in Reducing Blood Pressure in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Abstract Blood pressure (BP) is a major health burden in low- and middle-income countries (LMICs), where effective control remains a challenge. Community-based education may help improve outcomes in these settings. To systematically review and assess the impact of community-based...

Multimodal Feedback-Enhanced Soft Hand Rehabilitation Robot: System Development and Preliminary Clinical Evaluation

Soft robotic systems have attracted increasing attention for hand rehabilitation because of their compliance, adaptability, and potential for comfortable human–robot interaction. However, the clinical translation of soft hand rehabilitation robots remains limited by insufficient...

Awareness and use of university mental health services among engineering and science undergraduates at two public universities in Tanzania

Abstract Background Evidence on the pathway from mental-health awareness to actual use of university services remains limited in Tanzania. This exploratory cross-sectional mixed-methods study described anxiety and depressive symptom burden, awareness of common mental disorders an...

Silicone Band Loop Myopexy for Strabismus Fixus in Heavy Eye Syndrome, Highly Myopic Sagging Eye Syndrome, and Sagging Eye Syndrome

Purpose: To report the surgical outcomes of silicone band loop myopexy in patients with strabismus fixus associated with heavy eye syndrome (HES), highly myopic sagging eye syndrome (SES), and SES. Methods: This retrospective case series included 8 patients with strabismus fixus...

Optimization of the Extraction Process and Preliminary Purification of Total Flavonoids from Hedysari Radix Using Response Surface Methodology

Hedysari Radix, a valuable traditional Chinese medicinal herb, is rich in flavonoid constituents with considerable potential for the development of anticancer and immunomodulatory therapeutic agents. In this work, an integrated high-efficiency technical workflow was constructed f...

Who is counted? The (in)different selection of population figures for measuring malapportionment

Abstract Who is counted? To realize the “one person, one vote” principle and measure malapportionment, practitioners and political scientists have selected a population figure, or population count, arbitrarily or indifferently . Population figures include total population, eligib...

Comprehensive Experimental and Computational Spectroscopic Study of Electronic Coupling in Solvated Mixed Valence Multimetal Complexes Using Photons from the IR through X-rays

Abstract We present a comprehensive experimental and computational spectroscopic study of the trinuclear cyanide-bridged mixed-valence complex trans-[RuIIL4{(μ-NC)FeIII(CN)5}2]4– (FeRuFe), where L = pyridine or 4-methoxypyridine dissolved in methanol and water. Four complementary...

Beavers affect nitrate storage and transformation at the sediment–water interface

Abstract Rewilding is a restoration strategy aimed at re-establishing ecosystem processes and functions. This study focuses on the reintroduction of Eurasian beavers ( Castor fibre ) at a rewilding site at Knepp Estate, Sussex, UK, and their impact on nitrate (NO 3 − ) fluxes at...

Respiratory Pathogen Spectrum Among 12,220 Testing Episodes for Clinically Suspected Acute Respiratory Infection in Predominantly Hospitalized Patients at a Tertiary Hospital in Wuhan, China, 2025: A Retrospective Cross-Sectional Study

Acute respiratory infections (ARI) impose a substantial global disease burden, yet the post-pandemic pathogen spectrum in central China remains incompletely characterized. This single-center retrospective cross-sectional study analyzed 12,220 consecutive testing episodes in which...

Reversible Strengthening of Traditional Timber Members with Nano-SiO2-Modified CFRP in High-Humidity Environments

Timber-structure buildings are a common traditional architectural type in China whose value has shifted from residential use toward cultural heritage preservation, historical research, and cultural-tourism exhibition. In subtropical regions such as Fujian and Hunan, these structu...

Is There a Relationship Between the Gut Microbiome and the Functional Capabilities of Skeletal Muscle? A Narrative Review

Diet is one of the primary determinants of gut microbiota composition and its metabolic output. That output is emerging as a critical determinant of systemic health and has been linked to most physiological systems in the body, yet its relationship to skeletal muscle physiology h...