Research works

The Paradox of Growth Without Jobs: A Qualitative Analysis of Employment Policies and Unemployment Trends in Kenya

This study examines the paradox of sustained economic growth alongside persistently high unemployment in Kenya, particularly among the youth. Despite notable GDP expansion driven largely by capital-intensive sectors such as infrastructure and services, job creation has not kept p...

Structure-Regulated Silk Fibroin Microneedle Patches for Minimally Invasive Glucose-Responsive Colorimetric Sensing

Abstract Minimally invasive microneedle devices have emerged as highly promising platforms for localized interstitial fluid (ISF) sensing and biomarker detection. In this study, we present a bilayer silk fibroin microneedle system that leverages material structure regulation to a...

Consistency of urethroscopy vs. high-frequency ultrasound in diagnosing male urethral condyloma acuminatum

Abstract Objectives Urethral condyloma acuminatum(CA) is characterized by hidden growth, high treatment difficulty, high recurrence rate, and significant harm. Urethroscopy is a traditional method for examining male urethral CA. As a safe, non-invasive, highly reproducible, and c...

Evaluating the Efficacy of Police Restructuring in Kenya Through Officers' Perceptions: Evidence from Nairobi County

Globally, police organizations are facing multiple challenges linked to their complex operating environment. Anchoring on this, police organizations are reviewing their organizational structures and re-engineering them to meet the needs of their customers. This study sought to ev...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...

Behavior and Design of Bolted Splice Connections for C-PSW/CF Walls

Abstract This paper briefly summarizes the results from experimental and numerical investigations conducted on full-scale planar concrete-filled composite plate shear walls (C-PSW/CF) with bolted splice connections. These experimental results and numerical models are used to deve...

IMMUNOMODULATORY EFFECTS OF CURCUMIN COMBINED WITH PIPERINE ON INDUCED CARCINOGENESIS IN HAMSTER BUCCAL POUCH

Abstract Objective: Curcumin (Cu) exhibits antitumor and anti-inflammatory activity in oral carcinogenesis but has limited clinical translation due to poor bioavailability, which piperine (Pip) can improve. This study evaluated the antitumor and immunomodulatory effects of intrap...

A Numerical Method for Solving First-Order Nonlinear Volterra-Fredholm Integro-differential Equations Using Power Series Polynomials

This is a numerical approach for solving first-order Nonlinear Volterra-Fredholm Integro-differential equations with power series polynomials. The approach approximated Volterra-Fredholm Integro-differential equations using power series polynomials. The modelled problem is conver...

Extending eFall risk prediction to working-age adults within mental health and learning disability services: a clinical validation study

Abstract Most fall risk tools are developed for older adults; evidence in working-age populations receiving mental health services is limited. To externally validate the existing eFalls prediction model in working-age adults (18–65 years) within a UK integrated teaching National...

The Predictability of Macroeconomic Shifts: A Comparative Analysis of Policy Promises and Socio-economic Realities in Kenya

This research studies the predictability of macroeconomic shifts in Kenya, explaining why policy promises diverge from socio-economic realities between 2013 and 2024. The study uses desk-based methods and data from Central Bank of Kenya (CBK) reports, Economic Surveys from Kenya...

Ozonation Pretreatment to Enhance Coagulation–Flocculation and Biodegradability of Tannery Wastewater

Abstract Tannery wastewater is characterized by high organic loads, low biodegradability, and the presence of recalcitrant compounds, which hinder the efficiency of conventional treatment. In this study, ozonation was evaluated as a pretreatment step to enhance coagulation-floccu...

Integrating Islamic Values into School Management Practices to Enhance Teacher Collaboration and Organizational Effectiveness

This research study assessed the influence of an Islamic Values-Based Management (IVBM) intervention to enhance teacher collaboration and organizational effectiveness in elementary schools in Simunul, Tawi-Tawi. Using a quasi–experimental mixed methods design, the study examined...

Lead-Time Sensitivity of GFS Forecasts for the Deadly 2011 Nova Friburgo Disaster (Brazil): A Hindcast-Based Synoptic and Thermodynamic Assessment

Abstract The catastrophic rainfall of 11–12 January 2011 triggered hundreds of landslides and flash floods in the mountainous region of Rio de Janeiro state, Brazil, with Nova Friburgo among the affected municipalities. This paper assesses how the predictability of this event dep...

Modeling effective doses of therapeutic antibodies targeting clustered surface receptors

Abstract A longstanding practice for therapeutic dosing of monoclonal antibodies is to identify the maximally tolerated dose. However, this approach has encountered limited success with some antibodies, especially in failed cancer trials. Here we report on an alternative dose-fin...

Factors associated with selection of total hip arthroplasty versus hemiarthroplasty for femoral neck fracture in older adults: a nationwide analysis of 99,084 cases

BACKGROUND: Surgical management of displaced femoral neck fractures in older adults typically involves hemiarthroplasty or total hip arthroplasty (THA). Although clinical guidelines suggest that THA may be considered in selected healthier and cognitively intact patients, real-wor...

On the microlocal regularity of the Gevrey vectors for second order partial differential operators with non negative characteristic form of first kind

Abstract We study the microlocal regularity of the analytic/Gevrey vectors for the following class of second order partial differential equations $$\begin{aligned} P(x,D) = \sum _{\ell ,j=1}^{n} a_{\ell ,j}(x) D_{\ell } D_{j} + \sum _{\ell =1}^{n} i b_{\ell }(x) D_{\ell } +c(x),...

From Binary Randomness to Macroscopic Emergence A Microscopic Derivation of Nonuniformity Emergence, with the Load-Bearing Link Graded in Four Layers

Abstract. The macroscopic phenomenological equations of open systems — an income-minus-expenditure master equation, a gradient-flow relaxation, and a quasi-potential landscape — are usually posed as postulates. This paper supplies the microscopic link. Starting from a minimal den...

Appraisal of Built-Environment Agencies' Roles on Building Collapse in Lagos State, Nigeria

This study examined the roles, effectiveness, and spatial distribution of built environment agencies in mitigating building collapse in Lagos State, with the objective of assessing institutional performance, identifying operational gaps, and proposing improvement strategies. The...

Real-world analysis of depression-related adverse events associated with the adsorbed anthrax vaccine: integrating pharmacovigilance signals, machine learning risk prediction, and transcriptomic mechanisms

Abstract Background Anthrax remains a life-threatening zoonotic disease in resource-limited settings. Adsorbed anthrax vaccine (AVA, BioThrax) is the only United States-authorized preexposure prophylaxis for high-risk Bacillus anthracis exposure. Although AVA safety has been desc...

Detailed study of bifurcations in a rate model with excitatory and inhibitory neurons and adaptation

The dynamical behaviour of a population-based rate model with firing adaptation is studied. An excitatory and inhibitory population of neurons is recurrently coupled and a negative feedback term is added to the excitatory population as firing adaptation. In several studies of the...