Base-Promoted Hydrophosphorylation of Enaminones for the Synthesis of Geminal Phosphoryl Amino Ketones
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Abstract
Abstract The direct hydrophosphorylation reaction of NH-enaminones has been achieved by simple base promotion with diaryl phosphine oxides as reaction partners. The synthesis of divergent β-phosphoryl-β-amino ketones has been allowed under mild heating (30 °C) in a green medium of 2-methyl tetrahydrofuran (2-MeTHF) without employing any metal reagent.
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Authors: Gengxin Li, Quanquan Zhou, Xi Li, Jie‐Ping Wan
Institutions: Nanjing Forestry University, Jiangxi Normal University, Changsha Medical University