Changsha Medical University

Nanoporous titanium implant functionalized with sustained strontium release orchestrates immune microenvironment for enhanced osseointegration

Objectives Insufficient osseointegration remains a major limitation of dental and orthopedic implants. This study aimed to develop a strontium-releasing nanoporous titanium surface (TDS) with improved interfacial stability and immunomodulatory capacity to promote implant osseoint...

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

Base-Promoted Hydrophosphorylation of Enaminones for the Synthesis of Geminal Phosphoryl Amino Ketones

Abstract The direct hydrophosphorylation reaction of NH-enaminones has been achieved by simple base promotion with diaryl phosphine oxides as reaction partners. The synthesis of divergent β-phosphoryl-β-amino ketones has been allowed under mild heating (30 °C) in a green medium o...

Electrolyte- and Catalyst-Free Electrochemical Synthesis of Unsymmetrical Diorganoyl Selenides

Abstract A facile electrocatalytic radical coupling of Katritzky salts with diselenides for the efficient synthesis of various alkyl aryl unsymmetrical selenides has been developed under mild conditions. This sustainable protocol is driven by renewable electrical energy, features...

An improved class-shape transformation-based particle swarm optimization (ICST-PSO) algorithm and its application on airfoil aerodynamic performance optimization

In order to quickly and accurately obtain and optimize the aerodynamic performance of airfoils, an improved class-shape transformation-based particle swarm optimization (ICST-PSO) algorithm is proposed in this work. The proposed ICST-PSO algorithm is not only used to generate the...

The cardiovascular–liver–metabolic syndemic and mortality and life expectancy: two prospective cohort studies

Cardiovascular disease (CVD), metabolic dysfunction–associated steatotic liver disease (MASLD), type 2 diabetes mellitus (T2DM), and obesity frequently coexist and share overlapping pathophysiologic mechanisms, collectively constituting a cardiovascular–liver–metabolic (CLM) synd...

Clinical features of cough syncope: a systematic review

Abstract Background Cough syncope (CS) is a rare subtype of syncope that remains underrepresented in evidence-based medicine. We aimed to characterize the clinical features of CS, with the aim of improving recognition and optimizing management strategies. Methods We present five...

Cascade In Situ Iodination and Elemental Copper-Mediated Reductive Coupling for the Synthesis of 3-Difluoroacetate-Functionalized Chromones

Abstract Reported in this paper is an I2/Cu-mediated method for the synthesis of 3-difluoroacetate-functionalized chromones via cascade reactions between o-hydroxyaryl enaminones and alkyl difluoroacetates. The product construction involves a key in situ iodination generating 3-i...

Aptamer-engineered signal-loaded MCOFs as a turn-on fluorescent platform for trace detection of immunosuppressants and prognostic biomarkers in serum

The simultaneous detection of immunosuppressive drugs and prognostic biomarkers in the serum of post-transplant patients enables a more accurate assessment of patient status, allowing for timely adjustments to medication regimens and the prevention of graft-versus-host disease (G...

Decarbonylative arylation/alkylation of heteroarenes with aldehydes via triplet synergistic catalysis

The development of sustainable synthetic routes from aldehydes to functionalized heteroarenes is an important goal in organic synthesis, owing to the low cost and ready accessibility of aldehydes. However, the high bond dissociation energy (BDE) of the Ar-C(O) bond makes the phot...

Photoredox‐Catalyzed 1,2,2‐Trifunctionalization of Alkenes with 1,7‐Enynes and α‐Bromocarbonyls

Comprehensive Summary Cyclopenta[ c ]quinoline derivatives represent privileged structural motifs that exhibit remarkable potential biological activities, which have prompted considerable interest in developing green, efficient and general synthetic strategies for constructing th...

The Role of Eccentric Contraction Training in the Postoperative Rehabilitation of Patients With Total Knee Arthroplasty

ABSTRACT Background Eccentric contraction training may be associated with improved functional recovery after total knee arthroplasty (TKA), but its effects on pain, range of motion, and patient‐reported outcomes during the early postoperative period remain unclear. This randomize...

Evaluating potential risk factors linked to endometriosis

Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association between 108 traits and EMT by means of Mendelian randomizati...

The association between Oxidative Balance Score and anemia in adults

Oxidative stress is implicated in the pathogenesis of anemia. The Oxidative Balance Score (OBS), a comprehensive metric assessing the combined impact of dietary and lifestyle factors on oxidative stress, has not yet been investigated in relation to anemia prevalence. We conducted...

The immuno-cognitive crossfire: redefining age-related T and B cell dynamics as drivers of neurodegeneration and systemic inflammaging

Aging of the adaptive immune system is not a uniform decline but a patterned reorganization of T and B cell compartments that can drive both systemic inflammaging and neurodegeneration. This review synthesizes emerging evidence that CD8 + CD28− EMRA cells, regulatory T cell insta...

Joint associations of problematic smartphone use and cyberbullying victimization with depressive and anxiety symptoms among Chinese primary and secondary school students: a large-scale school-based study

Problematic smartphone use (PSU) and cyberbullying victimization (CBV) are independently associated with emotional problems among adolescents. However, whether their co-occurrence is associated with a greater burden of depressive and anxiety symptoms remains unclear. This study e...

Diagnostic utility of plasma metagenomic next-generation sequencing for bloodstream and localized infections in advanced HIV disease

Abstract Objectives To evaluate the diagnostic performance of plasma metagenomic next‑generation sequencing (mNGS) for suspected bloodstream infections (BSI) and localized infections in patients with advanced HIV disease. Methods We conducted a retrospective observational study o...

Phosphine-Mediated Photocatalytic Defluorinative Reductive Coupling of Alkynes and Trifluoromethyl Alkenes

Abstract The reductive coupling of alkynes and alkenes has emerged as a straightforward protocol for C–C bond formation from readily available feedstocks. Herein, we report a phosphine-mediated photocatalytic defluorinative reductive coupling of alkynes and trifluoromethyl alkene...

Photocatalytic Four-Component Sulfonylation/ Ipso -Spirocyclization of N -Arylpropiolamides with Thianthrenium Salts, DABSO and H2O: Access to 3-Sulfonyl-Azaspiro[4.5]trienones

Abstract A visible-light-induced sodium fluorescein-catalyzed four-component cascade reaction of N-arylpropiolamides, aryl thianthrenium salts, DABSO, and H2O has been developed, providing efficient access to diverse 3-sulfonyl-azaspiro[4.5]trienones in moderate to good yields. T...

Phage vB_KpnM_NB cocktail synergizing with amikacin in inhibiting persister cells of Klebsiella pneumoniae

ABSTRACT The emergence of multidrug-resistant Klebsiella pneumoniae (KPN) and antibiotic-tolerant persister cells poses a significant challenge to existing anti-infection therapies. Given the urgent need for sustainable alternatives to antibiotics, phage cocktails are emerging as...