Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model
Abstract
sensitivity. The cardiac myosin inhibitor MYK-581 reduced hypercontractility and improved diastolic function. Data from this large animal genetic model of HCM strengthen the mechanistic link between genetic variants and in vivo phenotypes and elucidate the mechanisms of myofilament-targeted therapies.
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Authors: Eric M. Green, Carlos del Rio, Kamel Shibbani, David Kyle Meyerholz, Joshua Gorham, Seong Kim, Daniel M. DeLaughter, Marcus P. Henze, Christopher S. Rogers, Lindsey Gifford, Melissa Kafa, Frank Rohret, J. Adam Goeken, Jared M. McLendon, Ryan L. Boudreau, Christine E. Seidman, Jessica C. Sieren, Robert M. Weiss, Jonathan G. Seidman, Abhay Divekar, Ferhaan Ahmad
Institutions: Harvard University, University of Iowa, Bristol-Myers Squibb (United States), Bristol-Myers Squibb (Germany), Exemplar Genetics (United States)