Tonicity drives collecting duct maturation in the mammalian kidney
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Abstract
Organ maturation is an emerging focus in the fields of organoid and developmental biology. The authors show that high tonicity drives the maturation of renal collecting ducts in vitro and in vivo, improving morphology, gene expression, and function.
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Authors: Daisuke Inoue, Koichiro Miike, Shunsuke Tanigawa, Kei-ichiro Yasunaga, Rae Maeda, Tomoko Ohmori, Sayoko Fujimura, Masashi Mukoyama, Tomomi Kamba, Jose F. Aramburu, Cristina López‐Rodríguez, Yuki Sugiura, Yuichiro Izumi, Ryuichi Nishinakamura
Institutions: Kyoto University, Kumamoto University, Barcelona Biomedical Research Park