Barcelona Biomedical Research Park

Tonicity drives collecting duct maturation in the mammalian kidney

Organ maturation is an emerging focus in the fields of organoid and developmental biology. The authors show that high tonicity drives the maturation of renal collecting ducts in vitro and in vivo, improving morphology, gene expression, and function.

The GPCRVP score reliably predicts the impact of GLP1R human variants on receptor function

Abstract Aims/hypothesis The glucagon-like peptide-1 receptor (GLP1R) is a key regulator of glucose homeostasis and body weight, and a major therapeutic target for type 2 diabetes and obesity. Individual disease risk and response to treatments may vary widely depending on the pre...

Quality of guidelines for the management and prevention of occupational risks during pregnancy: a systematic quality assessment using the Appraisal of Guidelines for Research and Evaluation (AGREE II)

OBJECTIVE: This review aimed to appraise the quality of existing guidelines on the management of occupational risks for employed women during pregnancy, identifying and describing their characteristics. METHODS: We systematically identified guidelines in MEDLINE, Embase, CINAHL,...