Kumamoto University

Probing Lattice‐Oxygen Redox in Pt‐WO 3 Nanocrystals by Operando Spectroscopy: Bridging Surface Chemistry and Ethanol Sensing

ABSTRACT Understanding how lattice oxygen participates in gas sensing remains a challenge in metal‐oxide chemistry. Here, we combine operando diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), operando Raman spectroscopy, ex situ electron paramagnetic resonance...

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

Abstract The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta,...

Finite-Basis Duality Estimate for the Surface-Code Threshold under Correlated Bit-Flip Errors

We apply finite-basis duality to a statistical-mechanical model introduced by Chubb and Flammia for the surface code under spatially correlated bit-flip noise, for which their mapping gives a random-bond Ising model with both two-body edge interactions and four-body face interact...

Attention-Like Hebbian Learning from Quantum Probability Flow and Quantum-Annealer Tests

We propose a quantum probability-flow principle for deriving local learning rules in associative memory. A transverse field defines leakage channels from data states, and minimizing the measured survival loss gives stability-driven updates. For imaginary-time, dephased dynamics,...

Structure-Function Study of Symmetrically Substituted Pyridine Derivatives Based on the Iron binding Site of Bleomycin

Abstract Symmetrical molecules were designed based on the bleomycin iron-binding site leading to an unexpected finding of a zinc-binding molecule SN-1. SN-1 and its derivatives inhibited/regulated zinc finger proteins HIV-EP1, farnesyltransferase, APOBEC3G, TRAF6, and ADAM17. HPH...

Discovery of Bis-ThioureaDerivatives as Human DNATopoisomerase IIα Inhibitors with Potent Anticancer Effects

Abstract DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Integrated Pharmacokinetic Assessment and Individualized Dosing in Pediatric Critical Care

Optimizing pharmacotherapy in pediatric intensive care requires an integrated understanding of developmental physiology and critical illness-related pathophysiology. Drug exposure in children cannot be interpreted as a simple scaled version of adult pharmacokinetics. Critically i...

Element-SpecificSensitivity of Lanthanoid Ions toChiral Crystal Fields in K3[Ln2(NO3)9] Probed by 4f–4f Circular Dichroism

Abstract For chiral inorganic crystals composed of achiral components, chiral crystal fields around metal ions are expected to play a key role in the emergence of chiroptical properties. Circular dichroism (CD) spectra can serve as useful probes of such chiral crystal fields. Her...

Change in the prognostic utility of regional left ventricular longitudinal strain values in patients undergoing transcatheter aortic valve implantation

BACKGROUND: To evaluate the difference in prognostic utility of echocardiographic parameters between pre- and post-transcatheter aortic valve implantation (TAVI) periods. METHODS AND RESULTS: This study enrolled 189 patients who underwent TAVI at Kumamoto University Hospital betw...

Stable core-encapsulation of indium-111 in crosslinked polyionic complex micelles and assessment of its biodistribution

Radioactive isotopes, such as Indium-111 ( 111 In), are pivotal for highly sensitive noninvasive imaging and targeted radiotherapy. However, achieving stable in vivo retention remains a critical barrier. Conventional nanocarriers typically rely on surface-bound chelators, exposin...

Examination of image conditions using multiway analysis of variance for predicting high-crash-risk intersections with image recognition AI

Traffic crashes on residential roads in Japan have declined only marginally in recent years, indicating a stagnation in safety improvements. A key challenge is the early identification of high‑risk intersections, yet existing image‑based prediction studies have not statistically...