Essen University Hospital

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyze...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Differential Impact of Bacterial Infection on Preterm Birth in Singleton and Twin Pregnancies and Its Association with Cervical Cerclage or Arabin Pessary: A Retrospective Cohort Study

Background: Bacterial infection’s differential impact in singleton versus twin pregnancies and the modifying role of cervical interventions remain unclear. The objective is to investigate the association between bacterial infection and preterm birth in singleton and twin pregnanc...

SOEP-LEE2: Data Updates and New Research Opportunities

Abstract The Socio-Economic Panel Linked Employer–Employee Survey, Version 2 (SOEP-LEE2), provides linked information on employees, establishments, and self-employed individuals in Germany. An earlier Data Observer article (Matiaske, Wenzel, Torben Dall Schmidt, Christoph Halbmei...

Mental Health Disorders, Suicide Attempts, Substance Use, and Substance Use Disorders in Adults with Fetal Alcohol Spectrum Disorders: A Gender-Separated Study

Abstract Fetal alcohol spectrum disorders (FASD) are a group of neurodevelopmental disorders caused by alcohol exposure during pregnancy. FASD is associated with various neurocognitive disorders over the entire lifespan. Comorbid mental health disorders seem to be highly prevalen...