Essen University Hospital

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Adoption of, attitudes towards, and perceived challenges of digital health in hospice and palliative care among professionals in Germany: a national cross-sectional web-based survey

Abstract Background Digital health technologies may support communication, symptom management, continuity of care, and access to services in hospice and palliative care. National data on their adoption, on professionals’ attitudes, and on perceived barriers are scarce. We examine...

Predicting nonunion – a hybrid machine-learning model combining patient factors and mechanobiological simulation features exceeds clinician accuracy

Aims To compare the accuracy of a mechanobiological simulation against that of clinicians in forecasting long bone nonunions, and to determine whether the simulation’s results can be effectively used as input for a machine-learning algorithm. Methods This was a retrospective diag...

Iterative user-centered evaluation of a context-driven clinical dashboard for melanoma treatment

Abstract This study evaluated a user-centered clinical dashboard using FHIR-Server data to improve information accessibility for physicians treating melanoma patients. Current electronic health record systems distribute critical information across multiple modules and prioritize...

Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens

Intestinal epithelial cells can present antigen to CD4 T cells. Here the authors show that epithelial cells must present translocated bacterial antigen for local CD4 resident memory T cells to be established.

Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma

Abstract Uveal melanoma (UM) is a rare but aggressive cancer arising from cells of the uveal tract that is highly resistant to therapy once it has metastasized. In drug screening experiments, we identified a high sensitivity of primary UM cell lines to the pan-histone deacetylase...

Parental needs and experiences with e-Health applications in chronic pediatric care – a scoping review

Abstract Background The number of children and adolescents living with a chronic condition is steadily increasing. These conditions often place a considerable burden on affected individuals and their families. E-Health applications have the potential to support families by provid...

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

ABSTRACT Natural killer (NK) cells are innate immune cells that eliminate virus‐infected and tumour cells by a plethora of signalling pathways, involving the production of cytokines and cytotoxic molecules. NK cell activation and functions demand substantial energy and fatty acid...

Advancing cancer care for adolescents and young adults: the role of the European Network of Expertise

Adolescents and young adults (AYAs, aged 15-39 years at cancer diagnosis) are recognized as a distinct patient group with specific clinical and psychosocial needs requiring tailored care. This article presents the Network of Expertise (NoE) on AYAs with cancer developed through t...

Surgery of gallbladder carcinoma: current standards validated on a European cohort

Summary Background Gallbladder cancer (GBC) is a highly aggressive malignancy with a poor prognosis and varied global incidence. Despite surgical resection being the primary treatment, optimal approaches remain heterogeneous and debated due to limited high-quality evidence. This...

Cisplatin enhances radiation-induced apoptosis in peripheral lymphocytes of cancer patients: in vivo and in vitro findings

Abstract Background Concurrent cisplatin and radiotherapy frequently cause severe acute hematologic toxicity. This study investigated whether lymphocyte apoptosis, quantified via the γ-H2AX pan-nuclear immunostaining assay, can serve as a reliable biomarker for the acute hematolo...

The kallikrein-kinin system modulates CD4+ T cell function and contributes to T cell migration into the brain after stroke

Abstract Ischemic stroke elicits a sustained thromboinflammatory response that critically shapes secondary brain injury. The kallikrein-kinin system (KKS) has been identified as the interface of vascular injury and inflammatory processes; however, its role in adaptive immunity re...

Topogram-based anatomical labelling of CT series: anatomy-aware CT data processing using deep learning

Abstract Objectives This study provides a Rapid Analysis and Processing of Image Data (RAPID) framework that combines deep learning-based CT topogram analysis with DICOM spatial geometry to enable reliable anatomical labelling of CT series independent of inconsistent textual meta...

A multicenter analysis of prognostic factors for patients undergoing re-irradiation for recurrent glioblastoma

Abstract Background Re-irradiation (re-RT) has gained popularity in the treatment of recurrent or progressive glioblastoma (rGBM) after first-line treatment. However, uncertainties regarding optimal treatment dose, fraction size and target volume definition remain. In this multic...

Integrative Muscle-Adipose Score (IMAS)

OBJECTIVE: To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients. BACKGROUND: Body composition (BC) reflects nutritional status and metabolic reserves and influ...

Multimodal large language model–assisted workflow for image-dependent very short answer question generation and response grading in neurosurgical residency assessment: development and validation study

Very short answer questions (VSAQs) reduce cueing but require substantial specialist effort to develop and grade, particularly when they involve neuroimaging. We evaluated an expert-supervised workflow using multimodal large language models (LLMs) to generate image-dependent neur...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

Abstract Intra-tumor heterogeneity in proliferation rates fundamentally influences cancer progression and treatment resistance. To investigate how continuous phenotypic variation shapes eco-evolutionary dynamics, we develop a phenotype-structured partial differential equation fra...

Placebo Analgesia Does Not Generalize From Pain to Interoceptive Abilities: A Preregistered Exploratory Study

Placebo pills reliably reduce pain. Pain perception is tied to increased arousal and heart rate. Heart rate perception is, in turn, closely related to interoceptive signals processing, for example, pain and autonomic regulation. However, no studies so far have systematically exam...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...