Temple University

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

Automated optimization of force field parameters against ensemble-averaged measurements with Bayesian inference of conformational populations

Accurate force fields are essential for reliable molecular simulations. These models are refined against quantum mechanical calculations and experimental measurements, which are subject to random and systematic errors. Bayesian Inference of Conformational Populations (BICePs) is...

Distinguishing Between Enforceable and On-The-Books State-Level Abortion Policies Over Time: Findings From a Policy Surveillance Study

OBJECTIVES: To describe trends in state-level abortion policies before the Dobbs v Jackson Supreme Court decision, distinguishing laws that have been enacted through legislation/regulation and are thus "on-the-books" from laws that are enforceable, ie, "on-the-books" laws not blo...

Patient-centered approaches in psoriasis management: lessons from the past and future directions

INTRODUCTION: Psoriasis is a chronic immune-mediated disease with physical and psychosocial burden that is not fully captured by measures of skin lesion characteristics. Advances in therapies, including multiple biologic treatments, have improved disease control, but gaps remain...

Loss of Quasiconvexity in the Periodic Homogenization of Viscous Hamilton–Jacobi Equations

Abstract. We show that in the periodic homogenization of uniformly elliptic Hamilton–Jacobi equations with quasiconvex Hamiltonians in arbitrary dimensions, the effective Hamiltonian is not necessarily quasiconvex. This observation is in sharp contrast with the first-order case,...

Cross-cultural adaptation of cancer health literacy instruments in Arabic: the CHLT-30-Arabic and CHLT-6-Arabic

Background Health literacy plays a crucial role in physical and mental health outcomes. Patients with chronic diseases, cancer patients in particular, shoulder a disproportionate burden due to limited health literacy. Limited cancer health literacy (LCHL) is a risk factor for dis...

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD)

Abstract Von Hippel-Lindau disease (VHLD) is a rare autosomal dominant disease, occuring in ~ 1 in 35,000 individuals. Overall, individuals with inherited mutations in the VHL tumor suppressor gene are predisposed to a variety of cancer, including high frequencies of clear cell r...

Colorblind retreat: how residents make sense of race and relocation from flood-prone areas

Over recent decades, the United States federal government has funded the purchase and demolition of flood-prone housing across the country through a policy known as managed retreat. As this policy has touched down in areas where residents and government actors look to adapt to gr...

Failure Modes of Total Wrist Arthroplasty: Cross-Sectional Analysis of FDA MAUDE Adverse Event Reports (2015-2025)

Background: Total wrist arthroplasty (TWA) is a motion-preserving alternative to wrist fusion for end-stage wrist arthritis, but concerns regarding long-term durability continue to limit broader use. Reported 10-year survivorship ranges from 70% to 80%, although real-world failur...

Pseudomonas aeruginosa-derived volatile organic compounds modulate AhR signaling to dysregulate airway mucus homeostasis

Pseudomonas aeruginosa frequently infects chronically diseased lungs and exacerbates airway mucus hypersecretion and failure in clearance. P. aeruginosa is metabolically versatile and secretes multiple volatile organic compounds (VOCs), which have been scrutinized as potential bi...

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...

Establishment and genomic validation of novel patient-derived xenograft models for drug discovery in gastrointestinal stromal tumor

Abstract Most gastrointestinal stromal tumor (GIST) patients develop clinical resistance to approved tyrosine kinase inhibitors (TKI). The development of effective treatment strategies for refractory GIST requires identification of novel targets for investigational agents and wel...

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Doping is a cornerstone strategy for enhancing charge transport in semiconducting polymers, important for their application in, for example, semi-transparent electrode materials, thermoelectric devices, and antistatic coatings. Both chemical and electrochemical doping have, for t...

Translational analysis of miRNA–mRNA regulatory networks in male rat and human prefrontal cortex following chronic opioid self-administration

Opioid use disorder (OUD) is a chronic condition driven by neuroadaptations that promote continued drug use. Identifying molecular mechanisms supporting these adaptations remains a major challenge. An understudied area that merits further investigation is the expression of microR...

Plant-Derived Compounds as Antibiotic Adjuvants Against Drug-Resistant ESKAPE Pathogens: Mechanisms of Action, Synergistic Strategies, and Translational Challenges

Background/Objectives: Antimicrobial resistance among ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens has become a major global health threat, significantly reducing t...

Collecting for Catherine the Great : Empire and the Assembling of New Granada’s Indigenous Language Texts (1785–1791)

Abstract In 1787, King Charles III of Spain ordered each of his viceroys to collect dictionaries and manuscripts in languages Indigenous to Spanish America that would be sent to Saint Petersburg for use in Catherine the Great’s universal dictionary. While scholars have examined t...

Social and Functional Risk Patterns and All-Cause Mortality Among US Adults with Chronic Liver Disease

Importance: Chronic liver disease requires sustained engagement with the health system, which co-occurring social and functional risks may disrupt. Whether these risks form reproducible patterns with different mortality associations is uncertain. Objective: To identify social and...

Protective Effects of a Polyphenolic Fraction of Bergamot in Improving the Welfare Index in Honeybees (Apis mellifera) Co-Exposed to Deltamethrin and Flupyradifurone: A Laboratory Cage Study

The simultaneous presence of multiple pesticide residues in the environment impairs honeybee health and survival. The toxicological interactions could result in additive, synergistic, or antagonistic effects as documented in previous studies. In most cases, the co-exposure produc...

Elevating excellence: Examining the effects of spatial competition on hotel quality

This study investigates how spatial competition influences the quality of hotel properties in the lodging market. We collected hotel characteristics and online rating data for 3,443 properties in Texas, USA, spanning from 2010 to 2019. A two-way fixed-effects panel data model ind...

Palliative Extracorporeal Membrane Oxygenation Decannulation: An Ethical, Evidence-Based Approach

BACKGROUND: Extracorporeal membrane oxygenation, although lifesaving, is invasive. Complications affecting all body systems mandate reevaluation of goals of care. When extracorporeal membrane oxygenation is nonbeneficial, planning for de-escalation/decannulation to allow natural...