Network models of cytoskeletal and extracellular matrix mechanics
Abstract
Network models offer a powerful framework for linking filament-scale properties to cell and tissue mechanobiology. Lattice-based, off-lattice, and active network approaches explain emergent phenomena including nonlinear elasticity, rigidity transitions, and force transmission in cytoskeletal and extracellular matrices. This Review synthesizes key theoretical advances and experimental insights, and outlines challenges in extending network models to living tissues, including mechanochemical coupling, multiscale integration, and structural heterogeneity.
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Authors: Moumita Das, Rae M. Robertson- Anderson, Parag Katira, Jennifer L. Ross, Michael Rust, Aravind Karanam
Institutions: University of Chicago, Syracuse University, San Diego State University, University of San Diego, Rochester Institute of Technology