University of San Diego

Microsolvation of Protonated Glycine: Infrared Spectra from Data-Driven Quantum Many-Body Simulations

Abstract Understanding how hydration reshapes the structure and conformational flexibility of biomolecular ions is essential for connecting gas-phase spectroscopy to behavior in aqueous environments. Glycine, the simplest amino acid, exhibits rich microsolvation behavior, with co...

Paying upfront: successful initial infections protect against severe future infections

Abstract Understanding the consistency with which individual hosts respond to repeated pathogen exposures is crucial for accurately modeling pathogen transmission and eco-evolutionary dynamics. When hosts face repeated pathogen exposures, immune memory is expected to reduce the p...

Management Patterns and Outcomes of Vestibular Schwannoma in Older Adults: Assessment of the SEER Database

OBJECTIVE: Vestibular schwannoma (VS) is a benign intracranial tumor that is increasingly diagnosed in older adults. The relative contributions of tumor burden and surgical management to overall survival in elderly and very elderly patients remain incompletely characterized at a...

Starch granules are instructive scaffolds for synergistic reinforcement and dissipation in hydrogel composites

A fundamental challenge in soft material design is the competition between rigidity and dynamicity, as stiffening mechanisms typically suppress energy dissipation. Here, we demonstrate that starch granules serve as instructive scaffolds that overcome this constraint, enabling the...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Discovery of Sphaeriaurantinsas Rapid-Acting Antiplasmodialswith Dual Activity in Blood and Liver Stages

Abstract The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelli...

Implementation of clinical grading committees in internal medicine sub-internships: implications for assessment accuracy and standardization

The Internal Medicine clerkship has faced challenges in ensuring fair and accurate grades, with past studies examining areas including unconscious bias, inter-rater reliability, and variability. To address these issues, the Alliance for Academic Internal Medicine recommends the u...

Demonstratingthe Chemoselective Lewis Acid Activityof Pyridine(Diimine) Bismuth Cations

Abstract Herein, we describe the preparation of a library of cationic bismuth(III) pyridine(diimine) compounds and the assessment of their Lewis acidity measured by their interaction with phosphine oxides, acid halides, and ketones. These bismuth compounds have acceptor number va...

A Melanoma Transplanted in Nude Mice Has Both Host‐ and Tumor‐Derived Blood Vessel‐ and Nerve‐Like Structures

Nestin-expressing stem cells located in the bulge area of the hair follicle can give rise to multiple cell types. In the present study, we subcutaneously transplanted red fluorescent protein (RFP)-labeled SK-MEL-5 human melanoma cells into nestin-driven green fluorescent protein...