Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers
Abstract
ABSTRACT Nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity are designed and their encapsulation and structure‐forming capabilities investigated in real‐time. These nano‐carriers are built from cellulose and peptide hydrogels in tandem with a nano‐stacked interwoven design and alternating hydro‐ and lipophilicity, thus enabling tuning of the lipophilicity of the carrier mesh for drugs of complementary lipophilicities. This allows for a variety of therapeutic applications, based on the nanoproperties of the hydrogel. Time‐resolved and in situ grazing incidence x‐ray scattering studies confirm the design and hydro‐ and lipophilicities of the fiber‐hydrogel composite and conclude their ability for carrying drugs of complementary properties site specific. This approach allows for a novel way of understanding the functionality of drug carriers using photon‐based approach.
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Authors: Elisabeth Erbes, Naireeta Biswas, Calvin J. Brett, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Dr Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, T.V. Sreevidya, José de Jesús Velazquez-Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert
Institutions: University of Göttingen, KTH Royal Institute of Technology, Technical University of Munich, University of Potsdam, Deutsches Elektronen-Synchrotron DESY, Heinz Maier-Leibnitz Zentrum