University of Potsdam

Cutting chart-review time and improving database accuracy in inflammatory bowel disease with human-in-the-loop large language models

Abstract Background Manual abstraction of electronic health records into research databases is a major bottleneck in clinical research, limiting scalability and introducing error. This challenge is particularly acute in inflammatory bowel disease surveillance, where clinically re...

When boundaries are crossed: Children's voices on care, power and accountability

Children's everyday accounts of life in Early Childhood Education and Care (ECEC) reveal the moral complexity of their relationships with adults, where care and control are intertwined. Drawing on participatory, child-centred research with 86 children in six German ECEC centres,...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

Capturing the Epistemic Uncertainty in Subduction Earthquake Rupture Parameters

ABSTRACT Subduction earthquakes are highly destructive and can trigger devastating tsunamis, highlighting the need for a consistent probabilistic seismic-tsunami hazard assessment. However, current approaches treat both hazards separately: tsunami models use static coseismic slip...

Exhumation of Grand Canyon’s basement along the Great Escarpment of Laurentia

The Grand Canyon encompasses two billion years of Earth history, but more than half this record is absent across a regionally extensive erosional surface known as the Great Unconformity. This enigmatic surface has been linked to multi-phase regional tectonics accompanying superco...

Entanglement by design: symmetry-guided periodic helical assemblies

Abstract In this paper, a selection of elegant, highly symmetric examples of three-periodic tangled nets and filaments is presented. They are constructed via familiar crystal nets using edges as geometric scaffolds for n-fold helical windings. Rather than providing a complete cla...

The Telephone AI Paradox: How Voice Agents Can Help Counter Unwanted Telemarketing Through Role-Based Automation, Transparency, and Governance

Unwanted telemarketing calls are a persistent source of consumer frustration and a legally regulated issue in Germany. At first glance, the idea of addressing this problem with AI-based voice technology appears contradictory: why should an automated caller help restore trust in a...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density

Abstract Background Flickering visual stimulation can evoke neural oscillations, which can influence ongoing brain activity. Electrophysiological recordings of neural oscillations in the ripple band (80–180 Hz) show that these high-frequency oscillations occur in the neocortex an...

SOEP-LEE2: Data Updates and New Research Opportunities

Abstract The Socio-Economic Panel Linked Employer–Employee Survey, Version 2 (SOEP-LEE2), provides linked information on employees, establishments, and self-employed individuals in Germany. An earlier Data Observer article (Matiaske, Wenzel, Torben Dall Schmidt, Christoph Halbmei...

Improving Vegetation Mapping from LiDAR Point Clouds Using a Transmissivity-Based Feature

Urban vegetation provides essential ecosystem services, including temperature regulation, air purification, noise reduction, and carbon storage. However, urban densification and climate-induced stresses increasingly threaten these ecosystems. Accurate classification of urban vege...

The journey of numbers from attention to motor processing: an embodied account of neural response to number magnitudes

Abstract Embodied cognition suggests numbers are linked to physical actions and sensory experiences. Additionally, sensory processing, thoughts or actions are modulated by attentional shifts/control. This study investigates how learned motor associations in individuals (finger-co...