Construction and Antitumor Efficacy of an Antigen-Adjuvant Self-Carrier Spherical Peptide Nanovaccine.

Abstract

central memory T cells.After antigen restimulation，the secretion levels of tumor necrosis factor-α and interferon-γ were significantly elevated，which indicated long-lasting immune memory. Conclusions A carrier-free spherical peptide nanovaccine based on the co-delivery strategy of MPLA and LMP was successfully constructed.By promoting dendritic cell activation and enhancing T cell immune response，this system exhibits significant antitumor activity and long-lasting immune memory effect.This study provides a new technical approach and an experimental basis for developing nanovaccines against tumors.