Dichloramine B: A Reagent for Regioselective Chloroalkoxylation of 3‐Aryloxindoles
Abstract
A catalyst‐ and additive‐free strategy for the direct chloroalkoxylation of 3‐aryloxindoles has been developed using dichloramine B as a readily available electrophilic chlorinating reagent and alcohols as alkoxy nucleophiles. Notably, dichloramine B is converted to benzenesulfonamide during the chloroalkoxylation process, which is regenerated to dichloramine B with Cl 2 in industry. This mild, operationally simple protocol affords aromatic‐chloro‐3‐alkoxyoxindoles with excellent regioselectivity and broad functional‐group tolerance.
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Authors: Niuniu Li, Lina Huang, Teck‐Peng Loh, Dechang Han, Rongbin Hu, Lijuan Liang, Peng Chen, Zhenhua Jia
Institutions: Henan University of Technology, Nanyang Technological University, Lanzhou Institute of Husbandry and Pharmaceutical Sciences