Lanzhou Institute of Husbandry and Pharmaceutical Sciences

Genome-Wide Association Study of Body Measurement Traits at Birth in Cattle

Hexi cattle are an indigenous beef breed developed through multigenerational crossing of Simmental and Mongolian cattle, exhibiting exceptional adaptability to arid and semi-arid environments alongside robust growth performance. To investigate the genetic architecture underlying...

Regulatory Mechanisms Underlying Flavonoid-Mediated Restructuring of the Rhizosphere Microbiome in Alfalfa (Medicago sativa L.) Under Salt Stress

This study employed two Medicago sativa L. varieties with contrasting salt tolerance—Zangmu No.1 (ZM1, salt-tolerant) and Zangmu No.2 (ZM2, salt-sensitive)—to investigate root exudate composition, rhizosphere microbiome assembly, and their potential correlations under 0 mM, 100 m...

Genetic Variation and Haplotype Structure of CFAP299 and PRDM8 Associated with Fiber Yield and Hair Length Traits in Tianzhu White Yak

Fiber yield and hair length are important economic traits in Tianzhu White Yak. However, the genetic variants associated with fiber production performance in this breed remain insufficiently characterized. This study aimed to investigate the associations of single nucleotide poly...

A novel Alhagi honey polysaccharide-Alum Pickering emulsion adjuvant enhances systemic and mucosal immunogenicity of a BVDV vaccine in calves

Mucosal surfaces are the primary barrier to infection. For pathogens like bovine viral diarrhea virus (BVDV) that invade via the intestinal mucosa, vaccines capable of inducing mucosal immunity are crucial for mounting a comprehensive immune response. In this study, a new assembl...

Preventive Effects of Fermented Yak Milk-Derived Lacticaseibacillus paracasei CD12-1 Against DSS-Induced Colitis in Mice

Ulcerative colitis is a chronic inflammatory bowel disease characterized by mucosal barrier disruption, dysregulated immune responses, and gut microbial imbalance. However, limitations of current therapies highlight the need for safe probiotic interventions. This study evaluated...

Dichloramine B: A Reagent for Regioselective Chloroalkoxylation of 3‐Aryloxindoles

A catalyst‐ and additive‐free strategy for the direct chloroalkoxylation of 3‐aryloxindoles has been developed using dichloramine B as a readily available electrophilic chlorinating reagent and alcohols as alkoxy nucleophiles. Notably, dichloramine B is converted to benzenesulfon...

Genome-Wide Association Study and Genomic Selection for Average Daily Gain in Ashidan Yak

Average daily gain (ADG) is a core quantitative trait determining the economic benefits of Ashidan yak, a polled new breed adapted to cold barn feeding on the Qinghai–Tibet Plateau. Unraveling its complex genetic architecture is crucial for early molecular breeding selection. In...

Ethanolic Extract of Sophora moorcroftiana Seeds Attenuates LPS-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages via Modulation of the p62/Keap1/Nrf2 Signaling Pathway

Despite the traditional application of Sophora moorcroftiana seeds (SMS) in Tibetan medicine for heat-clearing, damp-drying, anti-inflammatory and detoxifying properties, the anti-inflammatory mechanisms of SMS remain insufficiently understood and warrant systematic investigation...