AI & Computingarticle2026-08-18

Functional Multireference Alignment via Deconvolution

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Abstract

Abstract. This paper studies the multireference alignment (MRA) problem of estimating a signal function from shifted, noisy observations. Our functional formulation reveals a new connection between MRA and deconvolution: the signal can be estimated from second-order statistics via Kotlarski’s formula, an important identification result in deconvolution with replicated measurements. To design our MRA algorithms, we extend Kotlarski’s formula to general dimension and study the estimation of signals with vanishing Fourier transform, thus also contributing to the deconvolution literature. We validate our deconvolution approach to MRA through both theory and numerical experiments.

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View paper (DOI)Open access versionOpenAlexSIAM Journal on Mathematics of Data SciencePublished 2026-08-18

Authors: Omar Ghattas, Anna Little, Daniel Sanz-Alonso

Institutions: University of Chicago, University of Utah, Broad Institute