Preventative Germline Gene Editing via Biomimetic Soft-Robotic Delivery Prior to Puberty

Abstract

This concept paper presents a preventative, early-stage approach targeting reproductive stem cells (Spermatogonial Stem Cells/Oogonia) prior to puberty to mitigate monogenic neurodevelopmental traits. The framework integrates targeted lipid nanoparticles (LNPs) carrying base editors with a biomimetic, soft-robotic hydraulic micro-probe designed to navigate delicate reproductive tracts safely. Authored by Ines Abdallah.