Optimal Size of Electrocorticography Grids for Classification of Hand Movements

Abstract

Abstract Implanted Brain-Computer Interfaces (BCIs) hold significant promise as a replacement for conventional assistive technologies for people with extensive motor impairments. In recent years, significant progress has been made in enhancing BCI performance, bringing clinically viable systems within reach. Some of these developments rely on increasingly large numbers of high spatial-density electrocorticography (ECoG) electrodes, which enable the extraction of spatially detailed information from extensive brain areas, but may also elevate surgical burden, posing a challenge for the clinical adoption of implanted BCIs. To mitigate this risk, we conducted an exhaustive investigation of hand movement classification performance involving 4, 5, and 8 classes in nine individuals with epilepsy, exploring all possible rectangular ECoG subgrids within the 32-, 64-, and 128-channel grids that were implanted in these individuals. Our findings reveal that the surface area of ECoG grids can be substantially reduced by 75–94% compared to the original grids, without a meaningful decline in classification performance, if electrodes are placed over informative areas. Classification performance across datasets was stable for progressively smaller subgrids until a critical threshold of approximately 60mm 2 was reached, below which performance declined substantially. We show that smallest subgrids with an area above the threshold achieved equally high classification F1 scores (range 81.64-99.71%) as the full grids with an area > 230mm 2 (range 82.85-96.75%). We conclude that ECoG-based BCI can be used to accurately decode up to seven different hand movements from well-located grids with a small number of electrodes, paving the way for smaller and safer BCI implants.