Biochemistry, Genetics and Molecular Biology · Molecular Biology

Epigenetics and DNA Methylation

Moderate evidenceReview

Review compares epigenetic drugs with chemotherapy in relapsed T-cell lymphoma

This meta-analysis examined 38 studies involving 2,170 people with relapsed or treatment-resistant peripheral T-cell lymphoma. Regimens containing an epigenetic drug had tumor response rates similar to conventional chemotherapy, but the studies reported higher one-year progression-free and overall survival rates with the epigenetic-containing regimens. Because the comparisons were based mainly on separate cohorts rather than randomized trials, the results show an association rather than proof that one approach caused better outcomes.

3 days ago·25 views

Biology

Can plants pass stress memories to their offspring? The evidence is mixed

Plants can sometimes carry stress-related molecular changes into their offspring without altering their DNA sequence. But a review in PROTOPLASMA finds that the effect depends strongly on the species, gene region and reproductive system, limiting claims about broadly inherited stress memory.

1 week ago·29 views

Biology

In haddock, a fin sample predicted age to within about two months

A study of haddock from the Georges Bank–Gulf of Maine region used DNA methylation patterns in fin tissue to estimate age. The final model used 109 sites and had a reported mean absolute error of 0.17 years.

2 weeks ago·29 views