Zhejiang Cancer Hospital

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

pH responsive nanoplatforms for radiosensitization and radioprotection in cancer therapy

Radiotherapy remains a cornerstone of cancer treatment, but its efficacy is limited by tumor hypoxia, adaptive antioxidant defenses, and the resulting radioresistance. Tumor extracellular acidity, commonly reported within an approximate pH range of 6.5–7.1, contributes to invasio...

Is Body Roundness Index a Predictor of Cancer Incidence and Mortality? A Prospective Cohort Study

ABSTRACT Body Roundness Index (BRI) is a novel measure of visceral and total body fat. Its association with multiple cancers and predictive value relative to Body Mass Index (BMI) remain unclear. The associations between BRI and the incidence and mortality (specific, overall and...

Inferring tumor dependency maps from histopathology through imputed transcriptomics

Gene dependency maps from cancer cell lines define context-specific essential genes, but comparable dependencies in tumors remain largely inaccessible. This gap limits the identification of actionable therapeutic vulnerabilities. Here we present a two-stage deep learning framewor...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Thermal ablation for benign thyroid diseases, low-risk thyroid carcinoma, and metastatic cervical lymph nodes: A Chinese multidisciplinary expert consensus (2025 edition)

The clinical role of thermal ablation in thyroid disease management has broadened substantially over the past decade as imaging guidance and minimally invasive technologies have advanced. Although thermal ablation is increasingly used in selected thyroid conditions, global practi...

Clinical application of MR-Only in cyberknife stereotactic radiotherapy for brain metastases: a feasibility study

Due to the limited number of studies on MR-only stereotactic radiotherapy (SRT) for brain metastases using CyberKnife in the literature, this study systematically evaluates the dose calculations and image guidance accuracy of synthetic CT (sCT) and sCT-derived digital reconstruct...

Stability‐Enhanced Therapeutic Artificial Cells Based on a Lipid–Polymer Integrated Architecture

ABSTRACT Current artificial cells often lack robustness in the face of the complex physiological milieu. Additionally, the strategies for mimicking natural cargo exchange mostly rely on biological techniques, which involve integrating native channel proteins or adopting intact na...

RAB18-dependent recruitment of OPTN initiates selective lipophagy in osteoblasts

Selective lipophagy requires cargo recognition and recruitment of autophagy receptors to lipid droplets (LDs), yet the molecular mechanisms that couple LDs to the core autophagy machinery remain poorly defined. Here, we identified the small GTPase RAB18 (RAB18, member RAS oncogen...