Yunnan University

Liver cancer stem cells drive hepatocellular carcinoma progression and therapeutic resistance

Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with persistently high rates of therapeutic resistance and post-treatment recurrence. Liver cancer stem cells (LCSCs), a distinct subpopulation of cancer cells endowed with stem cell-like proper...

Sperm competition shapes anuran testicular architecture through tubule and tissue adjustments

Abstract Testis morphology may act as a determinant of sperm size, and the evolutionary pressure to produce longer sperm may impose functional constraints on testicular architecture. Postcopulatory sexual selection, particularly sperm competition, is widely recognised as a primar...

B-Matching Interdiction Problem on Undirected Trees

In this paper, we consider a network optimization interdiction problem, called the [Formula: see text]-matching interdiction problem on undirected trees with unit edge weights. Given an undirected tree [Formula: see text], each vertex [Formula: see text] has a capacity [Formula:...

Genomic and phenotypic characterization of phosphate-solubilizing strain YNK-FB0058, which potentially represents a novel species within the genus Phyllobacterium

Phosphate-solubilizing bacteria are soil-dwelling probiotics that promote plant growth and convert unavailable phosphorus into absorbable forms for plants. A phosphate-solubilizing strain, YNK-FB0058, which potentially represents a novel species within the genus Phyllobacterium ,...

Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling

Abstract Mitochondria catabolize nutrients by generating sequentially-ordered organic acid intermediates that are oxidized through the tricarboxylic acid cycle. Pathogenic accumulation of metabolic organic acids manifests as devastating organic acidemias/acidurias and other sever...

β-carboline derivative Z86 alleviates pulmonary fibrosis via suppressing TGF-β/Smad signaling

Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant fibroblast proliferation and excessive expression and deposition of extracellular matrix (ECM) by myofibroblasts, ultimately resulting in progressive and irreversible disorder or even loss of the pulmonary function....

Integrated Proteomic Profiling Reveals Dynamic Remodeling of the Intestinal Proteome in Toxoplasma gondii-Infected C57BL/6J Mice

The intestinal mucosa is the primary site of Toxoplasma gondii (T. gondii) infection and interaction with the host. While the intestinal responses have been characterized through transcriptomic and histopathological studies, a comprehensive, system-wide analysis of the functional...

Pan-Genomic Dissection of GH1 β-Glucosidases in Brassica rapa Identifies BrBGLU10 as an Important Regulator of Pollen Development

Glycoside hydrolase family 1 (GH1) β-glucosidases (BGLUs) play diverse roles in plant development and stress responses. However, a comprehensive pan-genomic characterization of this gene family across diverse Brassica rapa accessions is still lacking. Here, we conducted a pan-gen...

Aminosulfine‐Based Donor Platform for Controlled Release of Sulfenic Acid (HSOH)

ABSTRACT Reactive sulfur species derived from hydrogen sulfide are central regulators of redox signaling; however, sulfenic acid (HSOH) has remained largely inaccessible owing to the absence of chemically defined donor systems. Here we report a mechanistically delineated strategy...

Aminosulfine‐Based Donor Platform for Controlled Release of Sulfenic Acid (HSOH)

ABSTRACT Reactive sulfur species derived from hydrogen sulfide are central regulators of redox signaling; however, sulfenic acid (HSOH) has remained largely inaccessible owing to the absence of chemically defined donor systems. Here we report a mechanistically delineated strategy...

Trade‐Offs and Synergies in Cultivated Land Multifunctionality and Zoning Management in the Dongting Lake Region: A Multiscale Analysis

ABSTRACT Understanding the multiscale patterns and interactions of cultivated land multifunctionality is important for conservation, governance, and agricultural spatial optimization in the Dongting Lake region. Using 2020 data, we evaluated economic production (EPF), social secu...

Machine learning-based prediction models for chronic postsurgical pain after orthopaedic surgery: a scoping review

Chronic postsurgical pain (CPSP) is a burdensome complication following orthopaedic surgery. Machine learning (ML) offers potential for improved prediction; however, the methodological landscape remains unsynthesized. This scoping review mapped ML-based CPSP prediction models in...

Divergent Forest Cover Changes Dominate Inter‐Model Spread in Near‐Surface Wind Speed Trends Over China

Abstract Near‐surface wind speed (NSWS) regulates the intensity of land‐atmosphere fluxes and the viability of wind energy systems, playing a pivotal role in human adaptation to climate change. However, at the current stage, global climate models exhibit a wide inter‐model spread...

Exploration and practice of a DeepSeek‑enhanced, scenario‑based teaching model integrated with a multidisciplinary team approach in gastroenterology residency training

The first year of standardised residency training is a critical transition from medical student to clinical practitioner, during which trainees struggle to integrate theoretical knowledge with clinical competencies. Traditional teaching often lacks active learning and authentic c...

Spatiotemporal Variation of Vegetation and Its Responses to Climate Change in Pakistan

Abstract Changes in vegetation cover and its relationship with climate factors are crucial for ecosystem stability, especially in arid and semiarid regions like Pakistan. However, the impact of temperature and precipitation fluctuations on vegetation dynamics in these regions rem...

Electron transfer kinetics and molecular structural basis of dissolved black carbon as an electron shuttle

Dissolved black carbon (DBC) serves as a crucial electron shuttle in various biogeochemical cycles owing to its highly mobile and redox-active nature. Prior work on DBC electron-shuttling has focused on thermodynamic metrics—electron donating capacity (EDC) and electron accepting...

Electrode placement effects on Joule heating and thermal uniformity in an AC zinc-smelting furnace

The steady electrothermal behavior of AC zinc-smelting furnaces is governed by current redistribution and Joule-heat localization, which directly affect bath-temperature uniformity and refractory thermal loading. A three-dimensional one-way coupled electromagnetic-thermal-flow mo...

Fe(III)-MediatedOxidative [5 + 1] Cyclization forthe Highly Site-Selective Synthesis of Functionalized Quinoline Derivatives

Abstract We describe a method for the construction of highly functionalized quinoline derivatives from enaminones via an oxidative [5 + 1] cyclization. A plausible mechanism may involve a cascade sequence including single-electron transfer (SET), radical Michael addition, elimina...

2-Alkynyl-1-Naphthoate:A Reactive and Base-TolerantLeaving Group for Gold(I)-Catalyzed Glycosylation

Abstract 2-Alkynyl-1-naphthoate is disclosed as a reactive, base-tolerant leaving group for gold(I)-catalyzed glycosylation. Relocating the alkyne from C8 to C2 reduces steric congestion, facilitating donor preparation while preserving the anomeric ester under saponification cond...

Lost balance: synergy-redundancy dysfunction in Alzheimer’s disease

<title>Abstract</title> Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet reliable early biomarkers are still lacking, which greatly hinders timely intervention for AD. This study employed an integrated information decomposition framework to systematical...