Xi'an Jiaotong University

Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head

Cartilage degeneration in osteonecrosis of the femoral head (ONFH) is closely associated with chondrocyte heterogeneity. Single-cell RNA sequencing was performed on 50,851 chondrocytes from 10 ONFH patients and 10 controls. The findings were further validated using an in vitro ch...

The ER–Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses

Abstract The endoplasmic reticulum–Golgi intermediate compartment (ERGIC) is a dynamic membrane system at the ER–Golgi interface, traditionally viewed as a transient station for COPII- and COPI-dependent trafficking. Emerging evidence redefines the ERGIC as a stress-responsive re...

Impacts of anthropogenic aerosols on a snowfall event – a case study in the Guanzhong Basin and its surrounding areas, China

Abstract. Impacts of anthropogenic aerosols on clouds and snowfall during winter precipitation events remain highly uncertain, particularly under heavy pollution. A winter snowfall event over the Guanzhong Basin (GZB) and its surrounding regions (GZBs), China, has been simulated...

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

Red nucleus contributes to the maintenance of neuropathic pain in male rats via CCL3-CCR5 axis

The latest evidence indicates that the red nucleus (RN) contributes not only to motor control, but also to sensory processing and emotion regulation. Here, we demonstrate that the RN participates in the maintenance of neuropathic pain via CCL3-CCR5 axis. Following spared nerve in...

Ambient‐Processed Organic Solar Cells Achieving Nearly 20.5% Efficiency and Industrially Viable Environmental Stability

The ability to process organic solar cells (OSCs) in ambient air is a critical prerequisite for industrial-scale production, as it obviates the need for a high-cost inert atmosphere. However, state-of-the-art cathode interlayers (CILs) typically require strongly hydrophilic group...

Assortment Optimization for the Multinomial Logit Model with Repeated Customer Interactions

This paper presents the multinomial logit model with repeated customer interactions. In each period, the same customer selects a product from the recommended assortment or opts out. From the seller’s perspective, the choice probability in the current period is updated based on th...

High‐Fidelity Fabrication of 3D Multiscale‐Structured Pressure Sensors for High‐Performance Wearable Sensing

ABSTRACT Constructing multiscale structures has been regarded as a promising strategy to improve the overall performance of flexible pressure sensors. However, their manufacturing approach remains a challenge due to the lack of mild, compatible, and scalable processing methods. I...

Tourism Demand Probabilistic Interval Forecasting Approach With Integrated Deep PatchTST‐GMM Model

ABSTRACT Tourism demand forecasting is an important guide for decision‐making in related industries, especially because interval forecasting can provide managers with more decision‐relevant information than a single point estimate. In order to better forecast tourism demand, this...

A ReSCAL-based numerical study on synergistic optimization of photovoltaic arrays for sand control and power generation

In arid desert environments, photovoltaic (PV) arrays not only serve as clean energy suppliers, but also act as physical barriers to mitigate wind-blown sand movement. Based on the Real-Space Cellular Automaton Laboratory (ReSCAL), this study explores the coupled effects of PV ar...

Anti-nephrolithiatic Activity of Acacetin in Ethylene Glycol-Induced Nephrolithiasis in Rats

Nephrolithiasis, commonly known as kidney stones, is a prevalent urological disorder characterized by the accumulation of crystalline deposits in the kidneys. This condition is linked to considerable morbidity owing to the accompanying colicky pain, the necessity for surgical int...

ROS-Responsive, Water–Oil Biphasic Hydrogel-Based Separable Microneedle System for Intra-Articular Delivery in Osteoarthritis Therapy

Abstract Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment with excessive reactive oxygen species (ROS) and progressive cartilage degeneration. To address these challenges, we developed a ROS-responsive, water–oil biphasic separable microneedle patch...

Millimeter-thick microsupercapacitors with linear thickness-scaling of energy and power densities via multilayer electron highway architecture

The relentless miniaturization of microelectronics demands energy storage systems with ultrahigh energy and power densities in ultracompact footprints. Microsupercapacitors (MSCs) are promising due to their rapid charge-discharge capabilities, but conventional electrode architect...

Cellulose Tissue Separator With Aramid‐BaTiO 3 Composite Dielectric Coating Proactively Stabilizing Zinc Metal Anodes

ABSTRACT A fatal issue of zinc‐based electrochemical energy storage (ZEES) is uneven Zn 2+ deposition and rampant dendrite growth on the zinc metal anode, which significantly reduces the lifespan and reliability of ZEES devices. This work reports a cellulose tissue (CT) based sep...

Robust, Recyclable, and Reversibly Adhesive Polysulfide Elastomers via Inverse Vulcanization

Abstract Inverse vulcanization stands as a transformative strategy for valorizing surplus sulfur into polysulfides; however, inverse vulcanized polysulfides typically necessitate harsh synthetic conditions and suffer from an intrinsic trade-off between mechanical strength and net...

Halogen Substitution as a “Chirality Editor” for Amplifying Spin‐Selective Transport in Lead‐Free Metal‐Halide Hybrids

ABSTRACT Lead‐free metal‐halide hybrids hold promise as flexible semiconductors for X‐ray detection, but their application is constrained by inefficient carrier transport. Here, we introduce halogen substitution on chiral molecular cations as a “chirality editor” to modulate the...

Transient Power-Angle Stability Analysis of Grid-Forming Energy Storage in Renewable Energy Stations Connected to a Remote Power Grid

The increasing penetration of renewable energy has made the transient stability of new power systems a critical concern. Grid-forming (GFM) energy storage can provide voltage and frequency support for renewable energy stations. However, existing studies on the transient stability...

Assessment of Terrestrial Carbon Sinks: A Review of Methodological and Framework Limitations and Future Prospects

Ecosystem carbon sinks are a key indicator of terrestrial ecosystems' ability to absorb and store atmospheric CO₂. Their accurate assessment is of great significance for addressing global climate change and achieving carbon reduction targets. Due to limitations in the timeliness...

Demographic time bomb in COPD (1990–2050)

Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality, characterized by irreversible airflow limitation and progressive symptoms. Despite declining age-standardized rates (ASRs), absolute burdens are rising due to population aging and g...

Real-Time Heat-Sink Capability Monitoring Framework of Fuel Thermal Management System

With the proliferation of high-power electronics, electric propulsion, and directed-energy weapons, thermal management has evolved from a high-speed flight concern into a systemic bottleneck across subsonic, transonic, and supersonic aircraft. Conventional fuel thermal management...