Xiamen University

Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice

Cognitive impairment affects 30%–80% of patients with heart failure, yet the mechanisms beyond reduced brain blood flow remain poorly defined. Here we show that circulating factors released during heart failure trigger senescence of brain blood-vessel endothelial cells, which in...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...

UnravelingSulfur Vacancy Evolution Mechanism duringLow-Temperature H2 and S Vapor Annealing in Monolayer Mo(1– x )W x S2 Alloys

Abstract This study systematically modulated the healing and creation of S vacancies in monolayer Mo(1–x)WxS2 alloys via low-temperature H2 and S vapor annealing, observing three distinct types of photoluminescence (PL) evolutions. Type I featured intensified PL, a decreased X–/X...

Tailoring MicrophaseSeparation through Backbone SubstituentModulation in Poly(biphenyl alkylene) Anion Exchange Membranes

Abstract Anion exchange membrane (AEM) water electrolysis serves as an attractive approach for cost-effective hydrogen generation. However, achieving AEMs with both high ionic conductivity and robust alkaline stability remains challenging. Herein, a series of ether-free quaterniz...

Changes in the tropical rainfall seasonal cycle dominated by mesoscale convective systems

Global warming is reorganizing atmospheric circulation and hydroclimate, and tropical rainfall is a key manifestation of this response. Yet how these large-scale changes are translated into the tropical rainfall seasonal cycle remains uncertain because organized convection, which...

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

ABSTRACT Alveolar echinococcosis (AE), a lethal disease caused by the parasite Echinococcus multilocularis , is characterized by tumor‐like growths in a host‐derived oxidative microenvironment. The mechanisms that enable the parasite to adapt its central carbon metabolism to the...

Non-Linear Impacts and Spatial Variations in Multidimensional Built Environments on E-Shopping Decisions: Evidence from Shanghai

While e-commerce has transformed consumption patterns, online shopping behavior remains influenced by the physical environment. Using Shanghai as a case study, this research applies machine learning, SHAP analysis, and K-Means clustering to examine the nonlinear impacts and spati...

From the norms on social media to young people’s online aggressive behavior: the mediating effect of moral disengagement

Purpose In the social media era, cyberspace can foster undesirable norms that erode moral boundaries and fuel cyber aggression, especially among young people. Integrating the Theory of Normative Social Behavior and the Theory of Planned Behavior, this study systematically explore...

Global Disparities in the Recreational Fishery Economy: A Systematic Review

Recreational fisheries contribute significantly to global economies through tourism, employment, and ecosystem service valorization. However, a systematic understanding of their economic magnitude and regional disparities remains fragmented. This study conducts a systematic revie...

Atomically Precise Rigid Copper Nanocluster as an Air‐Stable Photocatalyst for Three‐Component Coupling Reactions

ABSTRACT Copper‐based catalysts exhibit high versatility in organic synthesis. However, their practical utility is often constrained by the limited stability and sensitivity to reaction conditions. In this study, we report a μ 3 – η 1 –S‐bridged nanocluster (NC), Cu 3 (DPPM) 3 S(...

Atomically Precise Rigid Copper Nanocluster as an Air‐Stable Photocatalyst for Three‐Component Coupling Reactions

ABSTRACT Copper‐based catalysts exhibit high versatility in organic synthesis. However, their practical utility is often constrained by the limited stability and sensitivity to reaction conditions. In this study, we report a μ 3 – η 1 –S‐bridged nanocluster (NC), Cu 3 (DPPM) 3 S(...

Carbohydrate food structure before sugar dose in metabolic ageing after hypertension or diabetes

Hypertension and diabetes make large populations candidates for dietary counseling, yet carbohydrate advice is often narrowed to reducing sugar intake. This study asked whether carbohydrate food structure should be assessed before sugar dose using biological ageing and renal risk...

Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma

Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...

MetabolicRNA Labeling: Adding a Temporal Dimensionto Transcriptomics and Epitranscriptomics Analysis

Abstract Transcriptomics and epitranscriptomics analyses have provided unprecedented insights into the transcriptome-wide RNA abundance and the post-transcriptional modifications of RNA across diverse biological processes. However, conventional transcriptomics and epitranscriptom...

Activatingthe Gate-Opening Effect in Multivariate MOFs by Defect Engineeringfor Oxidative Desulfurization

Abstract Metal–organic frameworks (MOFs) have shown great potential in catalytic oxidative desulfurization (ODS), yet their efficiency is often hampered by intrinsically inaccessible pore networks that impede the contact between active sites and reactants. To unlock the potential...

Specific Binding Agents for the Molecular Recognition of Biotoxins: Recent Advances and Applications in Forensic Toxicology

The precise detection and profiling of biotoxins are of paramount importance in analytical and forensic toxicology. Investigating these toxicants within highly chaotic background matrices—ranging from postmortem biological fluids to suspected poisoning vehicles such as complex di...

Dual-SignalAmplification: Synergistic Integrationof Nanozyme-Catalyzed SERS Aptasensor with μHPLC Pre-enrichmentfor Ultrasensitive ATP Monitoring

Abstract The precise quantification of adenosine triphosphate (ATP) at physiologically critical femtomolar levels in complex biological fluids remains a formidable challenge, constrained by irreconcilable demands for extreme sensitivity, specificity, and operational robustness. C...

In Situ CdS-MediatedOrganic PhotoelectrochemicalTransistor Sensor for Highly Sensitive H2S Detection

Abstract Hydrogen sulfide (H2S) serves as an important gasotransmitter implicated in vascular regulation, neuroprotection, and redox homeostasis, and its aberrant fluctuation is closely associated with diverse pathological disorders. Consequently, the development of sensitive and...

Prediction of DistalMutation Effects in Enzymes viaIntegration of Molecular Dynamics Descriptors and Zero-Shot Model

Abstract Identifying beneficial distal mutations remains a key challenge in enzyme engineering, as such residues can regulate activity through long-range dynamical coupling and allosteric communication. Although protein language models effectively capture sequence and evolutionar...

MonovalentTargeting Nanotag-Mediated Single-MoleculeCounting by SP-ICP-MS

Abstract Accurate single-molecule quantification of biomolecular targets is essential for ultrasensitive bioanalysis and early disease diagnostics. Single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) enables the detection of individual metal nanoparticles wit...