Xiamen University

N -Acyl Hemiperaminals: From Bioactive Skeleton Editing of Artemisinin to Programmable Handles for α-Amido Functionalization and Bioactive Peroxides

Abstract Late-stage molecular editing is vital for drug diversification and SAR studies. However, programmable peroxide-based editing handles for amides, α-amino acids, peptide- and drug-relevant scaffolds remain largely unexplored, particularly N-acyl hemiperaminals. Inspired by...

A Radical Addition–Diradical Coupling Switch Unifies Cytochrome P450-Catalyzed Diketopiperazine Dimerization

Abstract Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP...

Supramolecular Polymerization of Triphenylamine[3]arenes for Switchable and Stimuli‐Responsive Chiroptical Properties

ABSTRACT The design of advanced photonic materials with integrated stimuli‐responsive properties remains coveted yet challenging. Herein, we demonstrate that chiral supramolecular assembly of triphenylamine[3]arenes (TPA[3]s) offers an efficient and modular solution to address th...

Acute Reactive Strength Responses and Peak Power–Performance Relationships After Flywheel Calf Raises in National‐Level Track‐and‐Field Athletes: A Randomized Crossover Trial

ABSTRACT This study examined reactive strength responses to flywheel eccentric calf raises performed under three inertial loads and the associations between peak power and post‐intervention reactive strength. Thirty‐seven national‐level male track‐and‐field athletes completed thr...

Deep Eutectic Solvents Featuring Dual Amino Sites for Efficient and Reversible CO2 Capture with Molecular-Level Insights

Abstract In this study, a series of nonaqueous deep eutectic solvents (DESs) with dual amino sites were facilely constructed, among which the optimal DES (AEtMImBr: MEA (1:5)) achieved a CO2 capture capacity of 0.204 g/g at 333.15 K and 1 bar. Moreover, this DES maintained stable...

An Interpretable XGBoost-SHAP framework for rapid regional assessment of liquefaction-induced lateral spreading in mildly sloping ground

Liquefaction-induced lateral spreading poses significant risks to infrastructure on mildly sloping ground during earthquakes. This study develops an interpretable machine learning (ML) framework for rapid regional-scale prediction of liquefaction-induced displacement using an Ext...

Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses

Abstract Long-acting drug–Fc conjugate (CD388) has emerged as a new class of antivirals against influenza A and B, yet the mechanisms governing how Fc conjugation reshapes small-molecule function remain undefined. Here we establish a programmable multivalent antiviral conjugates...

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Abstract Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Here...

Three-decade trends in nonalcoholic fatty liver disease across 204 countries and territories

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading chronic liver disease globally, driven by the rising incidence of obesity, type 2 diabetes, and metabolic syndrome. Despite the increasing burden, most studies focus on prevalence rather than incidence, leaving a g...

Control of Electronic Properties of Organic–Inorganic MXenes via Surface Functionalization

Abstract Surface terminations critically affect the electronic structure of two-dimensional (2D) transition metal carbides and nitrides (MXenes), yet the synthetic exploration has been hindered by the lack of predictive factors. Here, we establish that the number of lone-pair ele...

VQ-Transformer: A deep learning-driven model for transcription factor sequence identification

Background Transcription factors are key proteins that regulate gene expression, and their accurate identification is important for elucidating the mechanisms of life activities. Traditional methods for identifying transcription factor sequences rely on manually designed features...

Molecular Fingerprint-Dependent Retention and Fractionation of Combustion-Derived Dissolved Organic Matter on Kaolinite and Montmorillonite

Abstract The environmental fate of combustion-derived dissolved organic matter (CDOM) at clay mineral interfaces remains poorly understood. We applied FT-ICR-MS, XPS, and other techniques to investigate the interfacial behavior of CDOM from coal, charcoal, pinewood, and maize str...

Construction of Injectable Hydrogels Based on Cationic Porphyrins and Hyaluronic Acid for Wound Healing With Multimodal Antibacterial Therapy and Instantaneous Monitoring

ABSTRACT Although hydrogels with antimicrobial and monitoring have the potential for precision wound therapy, it is difficult to construct smart framework of hydrogels in molecular level. Herein, an in situ crosslinked antimicrobial conductive hydrogel (Au/HA‐TPP) based on 5,10,1...

OrchAlign: Orchestrated Multimodal Alignment for Gene Expression Prediction

Abstract Motivation Gene expression prediction benefits from integrating DNA sequences and epigenomic signals. Existing approaches typically combine these modalities using simple operations such as concatenation or summation, without explicitly modeling fine-grained token-level c...

scLDM: a conditional diffusion framework for single-cell perturbation prediction

Abstract Motivation Accurate prediction of single-cell responses to external stimuli is pivotal for deciphering gene regulatory mechanisms and accelerating data-driven drug discovery. However, effectively capturing the complex, non-linear mapping between intrinsic cell states and...

Rapid Simultaneous Quantification of Four Typical Phthalate Esters in Complex Food Matrices via Thermal Desorption–Dielectric Barrier Discharge Ionization Mass Spectrometry

Abstract Conventional analytical methods for detecting and quantifying phthalate esters (PAEs) in foods generally require lengthy sample pretreatment procedures and suffer from severe matrix interferences. To address these shortcomings, a fast analytical platform based on a therm...

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

Low miR-106a-5p is associated with burn-related DVT and may regulate endothelial injury via TXNIP

Among burn patients, deep vein thrombosis (DVT) frequently arises as a critical complication. This article aims to explore the mechanism of miR-106a-5p in DVT in burn patients, providing a basis for identifying early diagnostic markers and developing therapeutic targets. This stu...

Electrochemically Engineered Octahedral High-Entropy Alloy Nanocrystals for Enhanced Electrocatalysis

Abstract High-entropy alloys (HEAs) have attracted increasing attention and shown considerable promise for diverse applications. However, the shape-controlled construction of HEAs with well-defined facets remains a significant challenge due to the large chemical and structural co...

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

ABSTRACT Integrating structural order, permanent porosity, aqueous stability, and biological activity within a single supramolecular platform remains a central challenge in biomaterials science. Herein, we report a C 3 ‐symmetric conjugate ( TASe ) that unites benzoselenadiazole,...