Western University

A Novel Approach to Characterizing Patterns of Real-World Upper-Extremity Use During Walking and Activities of Daily Living in People with Subacute Stroke

In accelerometer-based measurement, the inclusion of upper extremity (UE) activity during walking can overestimate real-world functional UE use in people post-stroke. This study introduces a comprehensive, accelerometer-based approach to examining real-world UE use, including the...

Efficacy, Tolerability, and Safety of Pitolisant for Residual Sleepiness in Obstructive Sleep Apnea Treated with CPAP: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There is growing evidence on the use of pitolisant for the treatment of residual excessive daytime sleepiness (EDS) in adults with obstructive sleep apnea (OSA) treated with continuous positive airway pressure (CPAP). We conducted a systematic review and meta-analysis of randomiz...

Rearing history, larval density, and larval developmental stage affect volatile- and light-mediated diel hiding behavior in Mythimna unipuncta

<title>Abstract</title> Our previous study has shown that plant volatiles and light jointly influence the diel hiding behavior of <italic>Mythimna unipuncta</italic> larvae using the third instars of the laboratory colony. Here, we investigated the effect of rearing history, larv...

The journey of numbers from attention to motor processing: an embodied account of neural response to number magnitudes

Abstract Embodied cognition suggests numbers are linked to physical actions and sensory experiences. Additionally, sensory processing, thoughts or actions are modulated by attentional shifts/control. This study investigates how learned motor associations in individuals (finger-co...

Women’s experiences of intuitive exercise: A reflexive thematic analysis

This study sought to deepen understandings of intuitive exercise among women navigating physical activity contexts that reinforce societal gendered messages and norms about bodies and exercise, promote dysfunctional exercise attitudes and behaviours, and undermine sustained parti...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...

Brentuximab Vedotin in Severe Systemic Sclerosis: Data on Long-Term Follow-Up and Retreatment

Objectives We previously reported skin and forced vital capacity (FVC) improvements in an open-label clinical trial exploring the use of brentuximab vedotin (BV) in patients with severe diffuse cutaneous systemic sclerosis (dcSSc).[1] Long-term outcomes after therapy was disconti...

Distinct Clinical and Laboratory Profiles of Biopsy-Positive and Biopsy-Negative Giant Cell Arteritis: A Meta Analysis

Objectives Although temporal artery biopsy (TAB) remains the diagnostic reference for giant cell arteritis (GCA) in resource-restricted settings that lack access to imaging, up to half of clinically diagnosed patients have negative biopsy results.[1,2] This study aimed to describ...

Unpacking the Comparator: Mapping “Usual Care” in Non-Surgical Knee OA Trials

Objectives “Usual care” is a common comparator in randomized trials (RCTs) evaluating interventions for knee osteoarthritis (OA), but it lacks a standardized definition. This scoping review aimed to systematically map how usual care has been defined and reported in knee OA RCTs,...

Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

Objectives To test the performance of the 2025 ASAS-SPARTAN Revised Classification Criteria for Axial Spondyloarthritis (axSpA)[1] in a multicenter inception cohort of patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics w...

Telephone versus in-person administration of the Early Childhood Development Index 2030: a crossover study, Brazil, Canada, India and Malawi.

Objective: To examine agreement between telephone and in-person administration of the Early Childhood Development Index 2030 (ECDI2030) survey. Methods: -tests and intraclass correlation coefficients. Findings: : -0.36), regardless of modality. However, pooled and stratified intr...

Examining relationships between sensory processing sensitivity (SPS), physical activity context preferences, and physical activity self-efficacy in undergraduate students

Objective Although regular physical activity (PA) enhances health, university environments often contribute to substantial PA declines for students. This cross-sectional study investigated relationships between Sensory Processing Sensitivity (SPS), a personality trait amplifying...

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons

ABSTRACT Stress triggers rapid and reversible shifts in vital physiological functions from homeostatic operation to emergency response. However, the neural mechanisms regulating such functional stress states remain poorly understood. Here we identify a novel recurrent inhibitory...