Western University

Resilience profiles of children previously exposed to parental gender-based violence: A longitudinal decision tree analysis

Background Children exposed to parental violence (CEPV) may experience a range of adverse outcomes compared to non-exposed peers yet may demonstrate resilience shaped by both internal and external protective factors. Objective To longitudinally explore the profiles of protective...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Rethinking wireless communications through formal mathematical AI reasoning

Mathematical analysis has long underpinned wireless communication theory, yet the growing complexity of next-generation systems demands increasingly sophisticated reasoning from domain experts. Recent advances in AI mathematical reasoning, from formal theorem proving to large lan...

A DIAMETER AND HEMODYNAMIC REGULATION MODEL UTILIZING AN ARTERIOLAR NETWORK STRUCTURAL MODEL AND EXPERIMENT-BASED MACHINE LEARNING

Arteriolar regulation is central to maintaining adequate tissue perfusion, and its disruption can lead to adverse health outcomes. However, mechanisms governing vessel responses to complex environmental conditions within a network context remain uncertain. This study presents com...

Maternal Depression, Childhood Resting‐State Brain Connectivity, and Adolescent Depression During the COVID‐19 Outbreak

Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID-19 pandemic. To understand the comple...

Validating Wing Biopsies for Blood‐Borne Pathogen Characterization in Bats

Wildlife surveillance is critical for tracking disease emergence, characterizing pathogen diversity, and assessing spillover risks. Blood-borne pathogens are of particular interest for such efforts due to their global distribution, broad host taxa, and zoonotic potential. Despite...

Growth of aromatic hydrocarbon dust particles in the extremely metal-poor galaxy Sextans A

The mid-infrared spectrum of star-forming, high-metallicity galaxies is dominated by emission features from aromatic and aliphatic bonds in small carbonaceous dust grains, often referred to as polycyclic aromatic hydrocarbons (PAHs). In metal-poor galaxies, the abundance of PAHs...

Drought to deluge: Differential impacts of snow on mountain chickadee reproduction across the Sierra Nevada mountains

Changing climates are reshaping animal populations, but our understanding of how demographic trends are shaped by individual responses to local environmental conditions has historically been limited to long-term studies with restricted spatial scales. Participatory science (i.e....

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Multielectron Charge Storage Enables Cascade Electrochemiluminescence in an Atomically Precise Silver Nanocluster

ABSTRACT Atomically precise metal nanoclusters combine discrete electronic states with access to multiple redox levels, enabling multielectron charge storage and electrochemical light generation. Herein, cascade electrochemiluminescence (ECL) is demonstrated for the silver nanocl...

Effectiveness of Adding GLP ‐1 Receptor Agonists to SGLT2 Inhibitor Therapy in Chronic Kidney Disease: A Population Based Study

ABSTRACT Background Individually, sodium–glucose co‐transporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have been shown to reduce major kidney and cardiovascular events in patients with chronic kidney disease (CKD). However, evidence support...

Clinical and Functional Characteristics of Patients Receiving Single- or Multiple-Inhaler Triple Therapy in Obstructive Airway Disease: A Real-World Study

This document describes the database used for the data analysis presented in the article entitled “Clinical and Functional Characteristics of Patients Receiving Single- or Multiple-Inhaler Triple Therapy in Obstructive Airway Disease: A Real-World Study.” The database is provided...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...

Identifying barriers to cancer screening among people experiencing homelessness: a systematic review

People experiencing homelessness (PEH) face significant health disparities including higher morbidity from chronic diseases such as cancer. Despite the availability of screening programs for breast, colorectal, lung, and cervical cancers, screening availability and participation...

Starson's paradox: Treatment capacity in the presence of delusional thinking

The assessment of the capacity to consent to treatment for mental disorders remains a complex and contentious area of medico-legal practice in psychiatry around the world. In Canada, the definitive jurisprudential authority on the topic is the Supreme Court of Canada's landmark 6...

Ethical guidance for randomized controlled trials of donor interventions in deceased organ donation: a scoping review of international guidelines, consensus statements, and expert recommendations

Deceased donor interventions are nontherapeutic interventions to improve the likelihood of successful donation and transplant outcomes. Randomized controlled trials (RCTs) could strengthen the evidence base for donor interventions, but such trials face difficult ethical challenge...

The pursuitworthiness of team science collaborations in translational neuroscience

Neuroscientists investigating the neural bases of cognition in health and disease increasingly face choices about how to structure their programs of research. On the one hand, they can pursue independent investigator-led disciplinary specific research projects and seek funding th...

Multi-view ensemble learning for predictive analytics of telematics data using Bayesian model averaging

Abstract Telematics has emerged as one of the most critical data sources in today’s auto insurance industry. Despite the potential predictive value of telematics information for auto insurance claims, such data are typically available for only a small subset of policyholders, lea...

Hadley Williams and the development of modern surgery at the University of Western Ontario

Summary Henry Thomas Hadley Williams, known professionally as Hadley Williams, was a surgeon and teacher whose career illustrates the transformation of surgery in Canada from a craft learned by apprenticeship to a university and hospital discipline. Born in Devon, England, in 186...

Professional Development in Education: A Qualitative Study of Public School Teachers’ Perceptions of Meaningful Growth and Mandated Practice

The present study investigates the professional development (PD) experience of ten public school teachers in British Columbia. The teachers are regular participants in school and district-based professional development (PD) programs. The research seeks to investigate whether PD i...