Western University

Social Performance Feedback and Managerial Moral Self-Regulation: The Microfoundations of Corporate Social (Ir)Responsibility

Despite growing interest in the microfoundations of corporate social activities, prior research has not articulated the full chain connecting firm-level conditions to managers' psychological processes (a topdown pathway) and back to firm-level corporate social behavior (a bottom-...

Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention

Menopause represents a major neuroendocrine transition characterized by substantial hormonal, metabolic, vascular, and inflammatory changes that may increase vulnerability to cognitive decline and neurodegenerative disease. Declining estrogen levels during the menopausal transiti...

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Fatigue-induced decline and recovery of maximal motor unit firing rates did not differ between males and females in two muscles of the quadriceps femoris

Studies on sex-related differences in motor unit (MU) behaviour with muscle fatiguing tasks are limited, particularly during contractions of maximal intensity and usually to one muscle within a synergistic group. Therefore, the purpose was to investigate the influence of sex and...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

Towards unified AI-driven fracture mechanics: the extended deep energy method (XDEM)

Abstract Physics-Informed Neural Networks (PINNs) have recently emerged as powerful tools for solving partial differential equations (PDEs), with the Deep Energy Method (DEM) proving especially effective in fracture mechanics due to its energy-based formulation. Despite these adv...

Evaluating the performance of administrative data elements used to document homelessness among psychiatric patients in Ontario, Canada: a validation study

Housing information about patients admitted to hospitals is routinely documented in health administrative records, which are increasingly used to inform planning and research. This study aimed to evaluate the accuracy of these records in identifying people experiencing homelessne...

Acceptability and Feasibility of a Primary Care Hypoglycemia Prevention Program: A Pilot Study

OBJECTIVE Hypoglycemia, a major cause of morbidity for people with diabetes, is underrecognized in primary care, leading to underuse of risk mitigation strategies. This study reports the development and acceptability/feasibility testing of the Hypoglycemia Prevention Program (HPP...

Lamotrigine and other therapy-associated HLH syndromes: a review

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation that can occur secondary to medical interventions including immunomodulatory therapies such as immune checkpoint inhibitors and stem cell transplantation. However, lamotrigine and...

Hospitalization of Children in Foster Homes: A Canadian Cohort Study

BACKGROUND AND OBJECTIVES: In Canada, approximately 4% to 7% of children live in a foster home during their childhood. This study reports on hospitalizations of children in foster homes, with the hypothesis that rates of hospitalization are higher for children with foster home ex...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Self-Assembled Monolayersof Phosphorus–NitrogenCages

Abstract This study investigates the deposition of the phosphorus–nitrogen (PN) cage P2N6 onto Au and Cu surfaces using both vapor-phase and solution-phase methods. The P2N6 cage sublimes cleanly and reaches an onset of volatility near 83 °C, suitable for vapor-phase deposition p...

Heart Meets Brain: Insights into Neurocardiac Pathophysiology

The intricate relationship between the heart and the brain has transitioned from historical, cardio-centric theories to a modern, circuit-based, bi-directional framework known as neurocardiology. This review provides a comprehensive anatomical, physiological, and clinical synthes...

Role of Lewis centres on ethanol dehydrogenation over the Cu‐Cr/ γ ‐Al 2 O 3 system

Abstract A copper/chromium‐based catalytic formulation is evaluated for anaerobic ethanol dehydrogenation. Results indicate that the Cu–Cr interaction regulates dehydrogenation activity. This interaction increases the relative numbers of Lewis acid centres resulting in a superior...

Mapping basal ganglia circuitry in altered states of consciousness: from pathology to pharmacology

The precise neuromodulatory mechanisms underlying consciousness and its disorders, despite growing evidence in both animals and humans, remain poorly understood at the subcortical level. The basal ganglia, a key component of the cortico-basal ganglia-thalamo-cortical loop, are kn...

Is Postinflammatory Hyperpigmentation Truly “Post” in People With Darker Skin Tones?

This Viewpoint reviews how inflammation can coexist with hyperpigmentation, explains why inflammatory activity may be underrecognized in people with darker skin tones, and proposes an approach in which hyperpigmentation prompts continued assessment for persistent inflammation.

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

Passive sampling reveals composition of airborne bacteria and fungi across five East African cities

Airborne microbes significantly influence environmental processes and human exposure, yet they remain poorly characterized in Africa. This study presents a regional survey of airborne bacterial and fungal communities across 10 sites in five East African countries: Burundi, the De...

Seasonal variation of liver and muscle mercury across two populations of a freshwater sport fish

Abstract Objective North-temperate fishes fluctuate in their energy status, metabolic rate, and behavior in response to seasonal changes in temperature and light, which could influence tissue concentrations of biomagnifying contaminants like mercury (Hg). Yet, repeated sampling w...

Sympathetic action potential synchronicity and blood pressure regulation in healthy young adults

This study investigated sympathetic neural blood pressure regulation in humans by quantifying synchronous and asynchronous action potential (AP) discharge. Muscle sympathetic AP discharge was measured (microneurography; continuous wavelet transform) in twenty-one healthy young ad...