Western University

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Topical Finasteride 0.25% Solution for Female Pattern Hair Loss (FPHL) in Postmenopausal Women: A 52‐Week Retrospective Observational Study

BACKGROUND: Female pattern hair loss (FPHL), characterized by progressive follicular miniaturization, is the most common cause of hair thinning in women and increases in prevalence after menopause. While topical minoxidil is approved for FPHL, clinical response is variable. Oral...

HIV pre-exposure prophylaxis in US prison settings: a model-based cost-effectiveness study

Background HIV prevalence in prisons is three times higher than in the general community, and ongoing transmission risks highlight the importance of prevention, including pre-exposure prophylaxis (PrEP). We evaluated the effectiveness and cost-effectiveness of prison-based PrEP p...

Landscape of Canadian Stroke Motor and Cognitive Rehabilitation Trials: Trends, Strengths and Future Directions

ABSTRACT This study aims to systematically identify and describe all randomized controlled trials (RCTs) evaluating post-stroke motor and cognitive rehabilitation conducted in Canada, within the broader context of global post-stroke rehabilitation research. The present secondary...

Process-based evaluation of green roof models for assessment of heat mitigation efficacy in WRF (v4.3.1) and EnergyPlus (v8.6.0)

Abstract. Green roofs mitigate urban heat, but to fully assess their impact, green roof models must be integrated into urban climate models, where they provide critical surface boundary conditions. Ensuring their reliability requires evaluation, yet such efforts remain limited in...

Interaction of physical fitness and resting state functional connectivity on global cognitive function in older adults with mild cognitive impairment

Background Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer's disease. Physical fitness, including cardiorespiratory fitness and muscular strength, is associated with cognitive function in older adults. Resting-state functional connectivity (rsFC) is also...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Atomic Site-Specific Eigenstrain for Efficient Electrocatalysis

Abstract Strain engineering is a powerful approach to tailoring the performance of metal electrocatalysts. Despite substantial advancements in controlling the average surface strain and establishing its correlation with catalytic activity, the impact of strain at individual activ...

Flash Communication : Catching Platinum Red-Handed: Exhaustive Ligand Redistribution at a Tucked-In Iron Complex

Abstract Transmetalation conventionally entails the transfer of a single ligand (e.g., aryl, hydride, or alkyl) between two centers. Herein, we demonstrate a 3d-to-5d metal-to-metal transmetalation in which the iron center of an organometallic fulvene complex is formally replaced...

Microplastics in stair-step moss and lake water on Baffin Island, Nunavut, reflect a local source component

Microplastics (MPs) are contaminants of emerging Arctic concern due to their adverse effects on ecosystems, yet lake water and shorelands on Baffin Island, Nunavut, remain understudied for contamination. To address this knowledge gap, we investigated microplastic pollution in mos...

Reactionary aesthetics and the politics of dark femininity

In recent years, feminist politics have faced a renewed reactionary backlash. Drawing on Jilly Boyce Kay's articulation of the ‘femosphere’ and Asa Seresin's ‘heteropessimism’ as key theoretical frameworks, we explore how women in the femosphere advance reactionary politics by pr...

Multivariate analysis identifies distinct latent components and highlights the contribution of motor cortex neurochemistry to clinical variance in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is marked by substantial clinical heterogeneity across motor and extramotor domains, yet how different neuroimaging modalities jointly relate to this heterogeneity remains poorly understood. Prior ALS neuroimaging studies have largely...

Psychometric Properties of the French Version of the Provider Co-Management Index-RN

Background Strengthening primary care through team-based models is a global priority as strong primary care systems are consistently associated with improved outcomes. The Provider Co-Management Index for Registered Nurses (PCMI-RN) is a validated instrument measuring co-manageme...

Three decades of sexual and reproductive health literacy and information behaviour research on adolescent and young adult males: a scoping review

The transition to adulthood for adolescent and young adult males, those aged 17 to 24, is often characterized by heightened sexual and reproductive health (SRH) risks. These risks are frequently attributed to rigid masculinity norms, insufficiently targeted health interventions,...

Atrophic Papulosis: A Systematic Review of Pediatric Cases

BACKGROUND: Atrophic papulosis is a rare occlusive vasculopathy that can present with isolated cutaneous disease or with systemic involvement. Pediatric cases are uncommon, and existing reports are heterogeneous, limiting understanding of disease patterns, timing of organ involve...

Interface-aware adaptive layer-wise physics-informed neural networks for multilayer large-strain consolidation: a benchmark of architectures, training strategies, and trade-offs

Multilayer large-strain consolidation in stratified soils involves nonlinear pore-pressure dissipation, evolving deformation, and material discontinuities, which pose significant challenges for physics-informed neural networks (PINNs). This study develops a layer-wise adaptive PI...

Development and Patient-Level Internal Validation of an MRI-Based Radiomics Machine Learning Model for Preoperative Prediction of Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma: A Pilot Study

Background/Objectives: Cervical lymph node metastasis (LNM) is the main prognostic factor in oral squamous cell carcinoma (OSCC) and guides the extent of neck treatment. This retrospective pilot study aimed to develop MRI-based radiomics machine learning models for the preoperati...

Dietitian Views on Continuing Education Activities – A Canadian Survey

Purpose: Understanding dietitian participation and perceptions of continuing education (CE) can guide CE development, leading to faster implementation of evidence-based practices at the bedside. This survey explored CE activities that Canadian dietitians value to facilitate knowl...

Exploring the relationship between gut microbiota and pan-cancer: a meta-analysis of Mendelian randomization studies

The relationship between the gut microbiota and cancer is of increasing interest, but remains incompletely understood. This study synthesized evidence from Mendelian randomization (MR) studies to assess the association between genetically predicted gut microbiota abundance and pa...

Missed Child Communication Cues During Parent Technology Use and Child Language Development

This cross-sectional study investigates the association between parent technology use, missed child communication cues, and language production and comprehension in children aged 13 to 18 months.