Wellcome Centre for Integrative Neuroimaging

A precision health approach to medication management in neurodevelopmental conditions: a model development and validation study using four international cohorts

Abstract Psychotropic medications are commonly prescribed to children with neurodevelopmental conditions, but responses vary widely, prescribing is largely off-label, and the expertise required is concentrated in specialized programs. We developed artificial intelligence models t...

Anterior cingulate neurons perform parallel processing of fixated and peripheral information to guide information sampling and choice

Abstract We use our eyes to evaluate objects around us. Models of economic choice emphasise the impact of sequential fixation on valuation and choice, with prefrontal and anterior cingulate cortex (ACC) encoding values of fixated items. Yet whether these regions also evaluate non...

A mechanistic theory of planning in prefrontal cortex

Abstract Planning is critical for adaptive behaviour in a changing world, because it lets us anticipate the future and adjust our actions accordingly. While prefrontal cortex is crucial for this process, it remains unknown how planning is implemented in neural circuits. Prefronta...

Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

Abstract Non-invasive recordings using brain electrophysiology provide credible insights into decline in neuronal functioning with age. New approaches are required to translate these results into compelling clinical metrics and meet the global challenge of preserving brain health...

Neural sharpening of object categories through parafoveal priming

Abstract During natural vision, humans make saccades approximately every 250–300 ms to fixate on important objects in a scene. Given this rapid succession of eye movements, it has been proposed that visual processing begins in the parafovea, prior to fixation. Such parafoveal pre...

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

ACPC-MAP: a protocol for manually aligning structural T1-weighted magnetic resonance images to the anterior commissure – posterior commissure plane according to clinical standards

Abstract Realigning structural MR images to stereotactic AC-PC space is a standard procedure that enhances anatomical consistency both within and across neuroimaging studies, allowing for precise spatial localization and reliable cross-subject comparisons in both clinical and res...

Resolving the Abstract–Concrete Paradox in the Angular Gyrus:A Multimethod Investigation

Abstract Despite its well-established role in memory-guided cognition, whether and how the angular gyrus (AG) contributes to semantic processing remains unresolved. Connectomic work links the AG to abstract mentation, yet neuroimaging studies paradoxically show greater AG engagem...