Weill Cornell Medicine

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Sugar-rich foods exacerbate antibiotic-induced microbiome disruption

Diet shapes the composition of the gut microbiota1; however, the specific effects of distinct food groups on microbiome dynamics are unclear, particularly in circumstances of extreme perturbation. Here we evaluated the relationship between diet and intestinal microbiome dynamics...

Axillary Nodal Upstaging in cT1N0 Invasive Lobular Carcinoma

OBJECTIVE: To determine whether sentinel lymph node biopsy (SLNB) omission is applicable to stage 1 invasive lobular breast cancer (ILC). BACKGROUND: The SOUND and INSEMA randomized controlled trials demonstrated that SLNB omission is noninferior to performing SLNB in early-stage...

Truth, Reconciliation, and Transformation: Another Step Forward

In the aftermath of the murder of George Floyd, the American Academy of Pediatrics (AAP) Board of Directors published a policy statement entitled "Truth, Reconciliation and Transformation: Continuing on the Path to Equity."1 The statement acknowledged historical transgressions an...

Severe ulcerative colitis flare precipitating Guillain–Barré syndrome: a case report and literature review

Abstract Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can occasionally be accompanied by extraintestinal manifestations, though neurological involvement is very rare. Guillain–Barré Syndrome (GBS), an acute immune-mediated polyradiculoneuropat...

Emerging therapies for candidozyma auris ( Candida auris) : current landscape and future directions

Introduction The multidrug-resistant fungal pathogen Candidozyma auris (Candida auris) has spread rapidly across healthcare systems worldwide, emerging as a critical threat to patient safety. With a limited antifungal armamentarium increasingly compromised by rising resistance, t...

Randomized phase II trial of liposomal cytarabine and daunorubicin with or without pomalidomide in newly diagnosed acute myeloid leukemia myelodysplasia-related

Not available.

CXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis

Leptomeningeal metastasis (LM) is a fatal neurological complication of cancer. Proton craniospinal irradiation (pCSI) has emerged as a promising life-prolonging intervention for patients with LM, but response to this treatment varies. Here, we aimed to characterize the molecular...

"Not Just Me and My To-Do List": Understanding Challenges of Task Management for Adults with ADHD and the Need for AI-Augmented Social Scaffolds

Adults with ADHD often face challenges with task management, not due to a lack of willpower, but because of emotional and relational misalignments between cognitive needs and normative infrastructures. Existing productivity tools, designed for neurotypical users, often assume con...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

Federal Funding Cuts and the Future of Health Care in Schools

This Viewpoint discusses threats to and protections for school-based health services.

Gene–Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits

Introduction/Background: Observational links between circulating metabolites and lipid traits are often confounded by environmental factors. This study applied Mendelian randomization (MR) and gene–environment interaction MR (MR-G×E) to assess the average causal effects of geneti...

Pancreatic Cancer Screening and Early Detection: Where Are We Now?

Screening for pancreatic cancer with imaging techniques in high-risk individuals—including patients with a genetic predisposition, a family history, or precursor lesions—is critical for improving early detection and survival outcomes, and multimodal strategies that integrate AI-e...

Acute fibrinous and organising pneumonia (AFOP): a case series highlighting diverse aetiologies and clinical outcomes in three patients

Background Acute fibrinous and organising pneumonia (AFOP) is a rare histopathological pattern of acute lung injury characterised by intra-alveolar fibrin deposition and organising pneumonia. It has diverse aetiologies and highly variable clinical outcomes.Case presentations We r...

Pre-Diagnostic Plasma Endogenous Steroids and the Risk of Exfoliation Glaucoma

Purpose: Exfoliation glaucoma (XFG) is the most common secondary glaucoma. Prior studies suggest a higher incidence in women and links to reproductive history, implying estrogen-related pathways. Metabolomic data also indicated inverse associations with steroid-related plasma met...

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

Beta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has been studied primarily in mo...

Self-reported cannabis use following cash transfer: Estimating the short-term impacts of the Alaska Permanent Fund Dividend

Aims Researchers have hypothesized that cash transfers affect substance use through two competing pathways: relieving financial strain which could reduce use, or expanding spendable income, which could increase use. We tested whether payments from the Permanent Fund Dividend (PFD...

A decade of evaluating burnout among American medical students using the OLBI-MS

Abstract Burnout among physicians is a growing concern, particularly during recent years in the setting of the Covid-19 pandemic. Recently, greater attention has been paid to researching physician burnout and its downstream effects (i.e. depression, suicidality); however, a major...

Understanding the dynamics of decision-making in palliative care within collectivist contexts: integrative review

End-of-life decision-making in palliative care requires timely and compassionate communication to align care with patients’ goals and values. While shared decision-making is regarded as optimal for patient-centered care, its application in collectivist societies, where familial,...