Weill Cornell Medicine

STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells

The immune system integrates signals to regulate immune responses, forming complex context-dependent networks where identical cues produce distinct outcomes. Signal transducer and activator of transcription (STAT) transcription factors convert cytokine receptor engagement into tr...

Elevated Blood Lead Levels in Children With Sickle Cell Disease

ABSTRACT Background Although prior reports suggest sickle cell disease (SCD) as a risk factor for lead poisoning, this association remains understudied. This paper assesses the relationship between SCD and elevated blood lead levels (BLLs) in New York City children. Methods We co...

Response to Comment on: “Janus kinase inhibitors as an evolving treatment for lymphomas and immune-mediated complications”

Not available.

The role of matrix metalloproteinases in Alzheimer's disease and small vessel disease

Matrix metalloproteinases (MMPs) are a family of enzymes participating in maintenance and remodeling of the extracellular matrix. Their many types are involved in diverse, sometimes contrasting physiological processes, and they are ubiquitously present throughout the CNS. In this...

Conscientious objection to euthanasia: a qualitative study of palliative care physicians’ perceptions

Abstract Background Conscientious objection (CO) in healthcare is a pressing issue, particularly in euthanasia, where legal permissibility coexists with moral disagreement. CO is commonly framed as a principled refusal based on moral or religious convictions, often emphasizing te...

Quantitative CT in the real-world evaluation of progressive pulmonary fibrosis; the REVISE PPF multicentre observational study

Abstract Rationale and Objective We assessed whether an FDA-cleared quantitative CT (qCT) tool (Brainomix, e-Lung) identifies progressive pulmonary fibrosis (PPF) earlier than routine clinical diagnosis and evaluated the prognostic value of baseline and serial imaging biomarkers....

Sexual Orientation and Gender Identity Data and HIV Preexposure Prophylaxis Disparity Detection

Importance US federal reporting changes in 2025 removed sexual orientation and gender identity (SOGI) measures from health-center reporting, raising concerns about equity surveillance. Objective To quantify how incomplete or absent SOGI data are associated with detection of dispa...

A Classic Cutaneous Presentation of Thymoma-Associated Multiorgan Autoimmunity and Review of the Literature

Abstract: Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic syndrome characterized by graft-versus-host disease (GVHD)–like manifestations. The disorder is thought to arise from a disruption to central immune tolerance of T cells secondary to neoplastic g...

Delays in breast cancer presentation, diagnosis, and treatment in young women

BACKGROUND: Breast cancer (BC) in young patients is often identified at later stages, which can result in poor prognosis. It is important to investigate the factors influencing care delays and how delays affect outcomes. METHODS: This study included women aged ≤40 years at diagno...

Improving Professional Billing Practices in a Pediatric Hospital Medicine Section

BACKGROUND: Professional billing translates clinical complexity and physician work into Current Procedural Terminology (CPT) codes and work relative value units (wRVUs), which inform reimbursement and resource planning. Pediatric hospital medicine (PHM) involves complex, cognitiv...

Pediatric Mental Health Integration and Perceived Quality of Care

OBJECTIVE: This study examined how access to behavioral and mental health (B/MH) professionals varied across general and subspecialty pediatricians and whether access to, and degree of, B/MH integration in clinical settings was associated with pediatricians' perceptions of health...

From Classification to Cross-Modal Understanding: Leveraging Vision- Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is essential for kidney biopsy interpretation, yet it presents a harder setting than the broad organ- or disease-level recognition tasks commonly used in vision-language model (VLM) evaluation. In this task, all categories arise within the same r...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Dermal Fillers in Skin of Color: Safety Considerations, Cultural Perspectives, and Patient-Centered Approaches

BACKGROUND Patients with skin of color make up a growing share of aesthetic dermatology practice, yet evidence guiding filler treatment in this population remains limited. OBJECTIVE To review the evidence on dermal filler treatment in patients with skin of color, emphasizing safe...

The Process of Customization in Shoulder Arthroplasty: Advancements in 3D Design and Manufacturing

Three-dimensional (3D) printing has emerged as a powerful tool in joint replacement surgeries, enabling the creation of custom implants that address complex anatomical deformities. In shoulder arthroplasty, particularly in cases involving severe glenoid bone loss or fracture, cus...

Categorizing differences in postpartum hemorrhage management and associated clinical factors

Abstract Objective To examine whether there is variation in postpartum hemorrhage (PPH) management and whether differences are associated with patient‐level factors and delivery hospital. Methods This is a retrospective cohort study of patients delivered at ≥20 weeks of gestation...

Multidisciplinary Support for Children With Genodermatoses in Brazil: A RE ‐ AIM Evaluation of Casa Santa Teresinha's Community‐Based Model

ABSTRACT Genodermatoses impose substantial psychosocial and functional burdens on affected children and their families, yet structured community‐based support models remain underrepresented in the literature. We describe Casa Santa Teresinha , a Brazilian non‐profit organization...

Macrophage-supported metabolic adaptation drives tumor survival under nutrient stress

Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macrophage-derived nutrients, influencing tumor growth and therapeutic response. Prolonged...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

ATG exposure in T replete transplant for hematological malignancies: Real world analysis from BMT CTN 1202

Traditional weight-based dosing results in variable rabbit anti-thymocyte globulin (rATG) clearance, delaying CD4+Tcell-immune-reconstitution (CD4 + IR) and impacting outcomes. In a retrospective pharmacokinetic/pharmacodynamic analysis of patients undergoing first T-replete hema...